Citation: YU Hui-Cheng, HUANG Xue-Yi, LI Hao, LEI Fu-Hou, TAN Xue-Cai, WEI Yi-Chun, WU Hai-Ying. Preparation and Electrochemical Properties of Phenobarbital Molecularly Imprinted Polymer Sensor Based on a CuO Nanoparticle-Modified Glassy Carbon Electrode[J]. Acta Physico-Chimica Sinica, ;2014, 30(11): 2085-2091. doi: 10.3866/PKU.WHXB201409051 shu

Preparation and Electrochemical Properties of Phenobarbital Molecularly Imprinted Polymer Sensor Based on a CuO Nanoparticle-Modified Glassy Carbon Electrode

1.
1. Key Laboratory of Guangxi Colleges and Universities for Food Safety and Pharmaceutical Analytical Chemistry, Guangxi Key Laboratory of Chemistry and Engineering of Forest Products, School of Chemistry and Chemical Engineering, Guangxi University for Nationalities, Nanning 530006, P. R. China;
2. Guangzhou Research Institute of Nonferrous Metals, Guangzhou 510651, P. R. China

Received Date: 5 June 2014
Available Online: 5 September 2014
Fund Project: 广西教育厅科研项目(2013YB068) (2013YB068) 国家自然科学基金(21365004) (21365004) 广西自然科学重点基金(2013GXNSFDA019006) (2013GXNSFDA019006) 广西高等学校高水平创新团队及卓越学者资助计划(桂教人[2014]7 号) (桂教人[2014]7 号)广西研究生教育创新计划项目(gxun-chx2014120)资助 (gxun-chx2014120)

To improve the sensitivity of molecular imprinted electrochemical sensors, a molecularly imprinted polymer (MIP) film for the determination of phenobarbital (PB) was electropolymerized on a CuO nanoparticlemodified glassy carbon electrode. Methacrylic acid was used as the functional monomer and ethylene glycol maleic rosinate acrylate as a cross-linking agent in the presence of supporting electrolyte (tetrabutylammonium perchlorate). The electrochemical properties of CuO nanoparticle-modified molecularly imprinted and non-imprinted polymer (NIP) sensors were investigated by cyclic voltammetry (CV), differential pulse voltammetry (DPV), and electrochemical impedance spectroscopy (EIS). The results showed that the electrochemical properties of the CuO nanoparticle-modified MIP sensor were completely different from those of NIP sensors. X-ray diffraction confirmed that the nanoparticles were CuO. The morphology of the CuO nanoparticle-modified MIP sensor was examined under a scanning electron microscope. The CuO nanoparticles were uniformly distributed on the surface of the modified glassy carbon electrode, which improved the recognition sites of the modified MIP sensor. The response value of the DPV peak current showed linear dependence on the PB concentration in the range 1.0×10^-8 to 1.8×10^-4 mol·L^-1 (linear regression coefficient =0.9994) with a detection limit (S/N=3) of 2.3×10^-9 mol·L^-1. The results indicated that the CuO nanoparticle-modified MIP sensor is one of the most sensitive and selective sensors for PB determination. The prepared sensor was successfully applied for the determination of PB in practical samples and the recovery ranged from 95.0% to 102.5%.
- CuO nanoparticle,
- Phenobarbital,
- Molecular imprinted polymer,
- Electropolymerization,
- Sensor
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