Citation: ZHU Li-Ying, YAN Xiao-Qin, ZHANG Hong-Man, LIN Dong-Qiang, YAO Shan-Jing, JIANG Ling. Determination of Apparent Drug Permeability Coefficients through Chitosan-Sodium Cellulose Sulfate Polyelectrolyte Complex Films[J]. Acta Physico-Chimica Sinica, ;2014, 30(2): 365-370. doi: 10.3866/PKU.WHXB201312091 shu

Determination of Apparent Drug Permeability Coefficients through Chitosan-Sodium Cellulose Sulfate Polyelectrolyte Complex Films

1.
1 College of Sciences, Nanjing University of Technology, Nanjing 211816, P. R. China;
2 Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, P. R. China;
3 College of Food Science and Light Industry, Nanjing University of Technology, Nanjing 211816, P. R. China

Received Date: 6 October 2013
Available Online: 9 December 2013
Fund Project: 江苏省自然科学基金(BK20131406，BK20130917) (BK20131406，BK20130917)国家自然科学基金(21106064)资助项目 (21106064)

The permeability coefficient is a fundamental parameter for devices exploiting the controlled drugrelease behavior of films composed of chitosan and sodium cellulose sulfate (NaCS). Here, the transport of two model drugs with different solubilities, i.e., paracetamol and 5-aminosalicylic acid (5-ASA), was studied. The results showed that the permeability of the chitosan/NaCS film was closely related to the swelling properties. In addition, both the permeability and swelling properties of the chitosan/NaCS film were significantly influenced by the mass ratio of chitosan to NaCS, the molecular weights (M_w) of chitosan and NaCS, and the pH value. The permeability of paracetamol across the film was also investigated in simulated gastrointestinal solutions in in vitro tests. The results showed that the films have gastro-, intestine-, and colon-targeting drugrelease properties when they are exposed to simulated gastrointestinal fluids in sequence.
- Polyelectrolyte complex film,
- Chitosan,
- Sodium cellulose sulfate,
- Swelling,
- Permeability,
- Controlled drug release
1. [1]
  
  (1) Berger, J.; Reist, M.; Mayer, J. M.; Felt, O.; Gurny, R. Eur. J. Pharm. Biopharm. 2004, 57, 35. doi: 10.1016/S0939-6411(03)00160-7
2. [2]
  (2) Park, M. R.; Chun, C.; Cho, C. S.; Song, S. C. Eur. J. Pharm. Biopharm. 2010, 76, 179. doi: 10.1016/j.ejpb.2010.06.012
3. [3]
  (3) Van Der Gucht, J.; Spruijt, E.; Lemmers, M.; Stuart, M.J. Colloid Interface Sci. 2011, 361, 407. doi: 10.1016/j.jcis.2011.05.080
4. [4]
  (4) Assaad, E.; Blemur, L.; Lessard, M.; Mateescu, M. A.; Biomat,J. Sci. Polym. E 2012, 23, 1713.
5. [5]
  (5) Xia,W. S.; Liu, P.; Liu, J. Bioresour. Technol. 2008, 99, 6751.doi: 10.1016/j.biortech.2008.01.011
6. [6]
  (6) Chen, C.; Liu, M. Z.; Lu, S. Y.; Gao, C. M.; Chen, J. C.; Biomat,J. Sci. Polym. E 2012, 23, 2007.
7. [7]
  (7) Shu, X. Z.; Zhu, K. J. Int. J. Pharm. 2002, 233, 217. doi: 10.1016/S0378-5173(01)00943-7
8. [8]
  (8) Wang, M. J.; Xie, Y. L.; Zheng, Q. D.; Yao, S. J. Ind. Eng. Chem. Res. 2009, 48, 5276. doi: 10.1021/ie801295y
9. [9]
  (9) Xie, Y. L.;Wang, M. J.; Yao, S. J. Langmuir 2009, 25, 8999.doi: 10.1021/la9014338
10. [10]
  (10) Zhu, L. Y.; Lin, D. Q.; Yao, S. J. Carbohyd. Polym. 2010, 82,323. doi: 10.1016/j.carbpol.2010.04.062
11. [11]
  (11) Wu, Q. X.; Zhang, Q. L.; Lin, D. Q.; Yao, S. J. Int. J. Pharm.2013, 455, 124. doi: 10.1016/j.ijpharm.2013.07.048
12. [12]
  (12) Wu, Q. X.; Yao, S. J. Colloid Surface B 2013, 109, 147. doi: 10.1016/j.colsurfb.2013.03.035
13. [13]
  (13) Hejazi, R.; Amiji, M. J. Control. Release 2003, 89, 151. doi: 10.1016/S0168-3659(03)00126-3
14. [14]
  (14) Tozaki, H.; Komoike, J.; Tada, C.; Maruyama, T.; Terabe, A.;Suzuki, T.; Yamamoto, A.; Muranishi, S. J. Pharm. Sci. 1997,86, 1016.
15. [15]
  (15) Onishi, H.; Machida, Y. Biomaterials 1999, 20, 175. doi: 10.1016/S0142-9612(98)00159-8
16. [16]
  (16) Chen, G.; Yao, S. J.; Guan, Y. X.; Lin, D. Q. Colloid. Surface B2005, 45, 136. doi: 10.1016/j.colsurfb.2005.08.002
17. [17]
  (17) Zhang, J.; Yao, S. J.; Guan, Y. X. J. Membrane Sci. 2005, 255,89. doi: 10.1016/j.memsci.2005.01.025
18. [18]
  (18) Zhang, J.; Guan, Y. X.; Ji, Z.; Yao, S. J. J. Membrane Sci. 2006,277, 270. doi: 10.1016/j.memsci.2005.10.038
19. [19]
  (19) Zhao, Y. N.; Chen, G.; Yao, S. J. Biochem. Eng. J. 2006, 32,93. doi: 10.1016/j.bej.2006.09.007
20. [20]
  (20) Fluri, D. A.; Kemmer, C.; Baba, M. D. E.; Fussenegger, M.J. Control. Release 2008, 131, 211. doi: 10.1016/j.jconrel.2008.07.036
21. [21]
  (21) Van den Mooter, G.; Samyn, C.; Kinget, R. Pharm. Res. 1994,11, 1737. doi: 10.1023/A:1018911316021
22. [22]
  (22) Macleod, G. S.; Collett, J. H.; Fell, J. T. J. Control. Release1999, 58, 303.
23. [23]
  (23) Akhgari, A.; Farahmand, F.; Garekani, H. A.; Sadeghi, F.;Vandamme, T. F. Eur. J. Pharm. Sci. 2006, 28, 307. doi: 10.1016/j.ejps.2006.03.005
24. [24]
  (24) Macleod, G. S.; Fell, J. T.; Collett, J. H. Int. J. Pharm. 1999,188, 11.
25. [25]
  (25) Yao, S. J. Chem. Eng. J. 2000, 78, 199. doi: 10.1016/S1385-8947(00)00131-5
26. [26]
  (26) Donbrow, M.; Friedman, M. J. Pharm. Pharmacol. 1975, 27,633. doi: 10.1111/jphp.1975.27.issue-9
27. [27]
  (27) Zentner, G. M.; Cardinal, J. R.; Kim, S.W. J. Pharm. Sci. 1978,67, 1352. doi: 10.1002/jps.v67:10
28. [28]
  (28) Miller, M. D.; Bruening, M. L. Chem. Mater. 2005, 17, 5375.doi: 10.1021/cm0512225
29. [29]
  (29) Ofori-Kwakye, K.; Fell, J. T. Int. J. Pharm. 2001, 226, 139. doi: 10.1016/S0378-5173(01)00802-X
1. [1]
  Dong-Bing Cheng , Junxin Duan , Haiyu Gao . Experimental Teaching Design on Chitosan Extraction and Preparation of Antibacterial Gel. University Chemistry, 2024, 39(2): 330-339. doi: 10.3866/PKU.DXHX202308053
2. [2]
  Xiaoning TANG , Junnan LIU , Xingfu YANG , Jie LEI , Qiuyang LUO , Shu XIA , An XUE . Effect of sodium alginate-sodium carboxymethylcellulose gel layer on the stability of Zn anodes. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1452-1460. doi: 10.11862/CJIC.20240191
3. [3]
  Tao Jiang , Yuting Wang , Lüjin Gao , Yi Zou , Bowen Zhu , Li Chen , Xianzeng Li . Experimental Design for the Preparation of Composite Solid Electrolytes for Application in All-Solid-State Batteries: Exploration of Comprehensive Chemistry Laboratory Teaching. University Chemistry, 2024, 39(2): 371-378. doi: 10.3866/PKU.DXHX202308057
4. [4]
  Junjie Zhang , Yue Wang , Qiuhan Wu , Ruquan Shen , Han Liu , Xinhua Duan . Preparation and Selective Separation of Lightweight Magnetic Molecularly Imprinted Polymers for Trace Tetracycline Detection in Milk. University Chemistry, 2024, 39(5): 251-257. doi: 10.3866/PKU.DXHX202311084
5. [5]
  Kun Li , Na Gao , Shuangyan Huan , Yuzhi Wang . Design of Ideological and Political Education for the Experiment of Detecting Cadmium with Anodic Stripping Voltammetry. University Chemistry, 2024, 39(2): 155-161. doi: 10.3866/PKU.DXHX202307068
6. [6]
  Yukai Jiang , Yihan Wang , Yunkai Zhang , Yunping Wei , Ying Ma , Na Du . Characterization and Phase Diagram of Surfactant Lyotropic Liquid Crystal. University Chemistry, 2024, 39(4): 114-118. doi: 10.3866/PKU.DXHX202309033
7. [7]
  Ziheng Zhuang , Xiao Xu , Kin Shing Chan . Superdrugs for Superbugs. University Chemistry, 2024, 39(9): 128-133. doi: 10.3866/PKU.DXHX202309040
8. [8]
  Xilin Zhao , Xingyu Tu , Zongxuan Li , Rui Dong , Bo Jiang , Zhiwei Miao . Research Progress in Enantioselective Synthesis of Axial Chiral Compounds. University Chemistry, 2024, 39(11): 158-173. doi: 10.12461/PKU.DXHX202403106
9. [9]
  Shuang Yang , Qun Wang , Caiqin Miao , Ziqi Geng , Xinran Li , Yang Li , Xiaohong Wu . Ideological and Political Education Design for Research-Oriented Experimental Course of Highly Efficient Hydrogen Production from Water Electrolysis in Aerospace Perspective. University Chemistry, 2024, 39(11): 269-277. doi: 10.12461/PKU.DXHX202403044
10. [10]
  Shijie Li , Ke Rong , Xiaoqin Wang , Chuqi Shen , Fang Yang , Qinghong Zhang . Design of Carbon Quantum Dots/CdS/Ta₃N₅ S-Scheme Heterojunction Nanofibers for Efficient Photocatalytic Antibiotic Removal. Acta Physico-Chimica Sinica, 2024, 40(12): 2403005-. doi: 10.3866/PKU.WHXB202403005
11. [11]
  Zongfei YANG , Xiaosen ZHAO , Jing LI , Wenchang ZHUANG . Research advances in heteropolyoxoniobates. Chinese Journal of Inorganic Chemistry, 2024, 40(3): 465-480. doi: 10.11862/CJIC.20230306
12. [12]
  Yonghui Wang , Weilin Chen , Yangguang Li . Knowledge Construction of “Solubility of Inorganic Substances” in Elemental Chemistry Teaching. University Chemistry, 2024, 39(4): 261-267. doi: 10.3866/PKU.DXHX202312102
13. [13]
  Jianjun LI , Mingjie REN , Lili ZHANG , Lingling ZENG , Huiling WANG , Xiangwu MENG . UV-assisted degradation of tetracycline hydrochloride by MnFe₂O₄@activated carbon activated persulfate. Chinese Journal of Inorganic Chemistry, 2024, 40(10): 1869-1880. doi: 10.11862/CJIC.20240187
14. [14]
  Xinlong WANG , Zhenguo CHENG , Guo WANG , Xiaokuen ZHANG , Yong XIANG , Xinquan WANG . Enhancement of the fragile interface of high voltage LiCoO₂ by surface gradient permeation of trace amounts of Mg/F. Chinese Journal of Inorganic Chemistry, 2024, 40(3): 571-580. doi: 10.11862/CJIC.20230259
15. [15]
  Yiying Yang , Dongju Zhang . Elucidating the Concepts of Thermodynamic Control and Kinetic Control in Chemical Reactions through Theoretical Chemistry Calculations: A Computational Chemistry Experiment on the Diels-Alder Reaction. University Chemistry, 2024, 39(3): 327-335. doi: 10.3866/PKU.DXHX202309074
16. [16]
  Rong Tian , Yadi Yang , Naihao Lu . Comprehensive Experimental Design of Undergraduate Students Based on Interdisciplinarity: Study on the Effect of Quercetin on Chlorination Activity of Myeloperoxidase. University Chemistry, 2024, 39(8): 247-254. doi: 10.3866/PKU.DXHX202312064
17. [17]
  Hong Zheng , Xin Peng , Chunwang Yi . The Tale of Caprolactam Cyclic Oligomers: The Ever-changing Life of “Princess Cyclo”. University Chemistry, 2024, 39(9): 40-47. doi: 10.12461/PKU.DXHX202403058
18. [18]
  Xinting XIONG , Zhiqiang XIONG , Panlei XIAO , Xuliang NIE , Xiuying SONG , Xiuguang YI . Synthesis, crystal structures, Hirshfeld surface analysis, and antifungal activity of two complexes Na(Ⅰ)/Cd(Ⅱ) assembled by 5-bromo-2-hydroxybenzoic acid ligands. Chinese Journal of Inorganic Chemistry, 2024, 40(9): 1661-1670. doi: 10.11862/CJIC.20240145
19. [19]
  Qin Hou , Jiayi Hou , Aiju Shi , Xingliang Xu , Yuanhong Zhang , Yijing Li , Juying Hou , Yanfang Wang . Preparation of Cuprous Iodide Coordination Polymer and Fluorescent Detection of Nitrite: A Comprehensive Chemical Design Experiment. University Chemistry, 2024, 39(8): 221-229. doi: 10.3866/PKU.DXHX202312056
20. [20]
  Qingqing SHEN , Xiangbowen DU , Kaicheng QIAN , Zhikang JIN , Zheng FANG , Tong WEI , Renhong LI . Self-supporting Cu/α-FeOOH/foam nickel composite catalyst for efficient hydrogen production by coupling methanol oxidation and water electrolysis. Chinese Journal of Inorganic Chemistry, 2024, 40(10): 1953-1964. doi: 10.11862/CJIC.20240028

Get Citation

PDF

XML

Metrics

PDF Downloads(458)
Abstract views(641)
HTML views(2)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142