Citation: ZHU Li-Ying, YAN Xiao-Qin, ZHANG Hong-Man, LIN Dong-Qiang, YAO Shan-Jing, JIANG Ling. Determination of Apparent Drug Permeability Coefficients through Chitosan-Sodium Cellulose Sulfate Polyelectrolyte Complex Films[J]. Acta Physico-Chimica Sinica, ;2014, 30(2): 365-370. doi: 10.3866/PKU.WHXB201312091 shu

Determination of Apparent Drug Permeability Coefficients through Chitosan-Sodium Cellulose Sulfate Polyelectrolyte Complex Films

1.
1 College of Sciences, Nanjing University of Technology, Nanjing 211816, P. R. China;
2 Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, P. R. China;
3 College of Food Science and Light Industry, Nanjing University of Technology, Nanjing 211816, P. R. China

Received Date: 6 October 2013
Available Online: 9 December 2013
Fund Project: 江苏省自然科学基金(BK20131406，BK20130917) (BK20131406，BK20130917)国家自然科学基金(21106064)资助项目 (21106064)

The permeability coefficient is a fundamental parameter for devices exploiting the controlled drugrelease behavior of films composed of chitosan and sodium cellulose sulfate (NaCS). Here, the transport of two model drugs with different solubilities, i.e., paracetamol and 5-aminosalicylic acid (5-ASA), was studied. The results showed that the permeability of the chitosan/NaCS film was closely related to the swelling properties. In addition, both the permeability and swelling properties of the chitosan/NaCS film were significantly influenced by the mass ratio of chitosan to NaCS, the molecular weights (M_w) of chitosan and NaCS, and the pH value. The permeability of paracetamol across the film was also investigated in simulated gastrointestinal solutions in in vitro tests. The results showed that the films have gastro-, intestine-, and colon-targeting drugrelease properties when they are exposed to simulated gastrointestinal fluids in sequence.
- Polyelectrolyte complex film,
- Chitosan,
- Sodium cellulose sulfate,
- Swelling,
- Permeability,
- Controlled drug release
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