Citation: WANG Juan-Qin, BAI Hui-Yu, YI Cheng-Lin, LIU Na, LIU Xiao-Ya. Self-Assembled HA/PDM Particles and Emulsification Properties[J]. Acta Physico-Chimica Sinica, ;2013, 29(05): 1028-1034. doi: 10.3866/PKU.WHXB201302271 shu

Self-Assembled HA/PDM Particles and Emulsification Properties

1.
Key Laboratory of Food Colloids and Biotechnology, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, Jiangsu Province, P. R. China

Received Date: 21 November 2012
Available Online: 27 February 2013
Fund Project: 国家自然科学基金(20974041)资助项目 (20974041)

The anionic biomacromolecule, hyaluronic acid (HA), and cationic monomer, 2-(dimethylamino) ethyl methacrylate (DM), were used to construct an opposing charge polymer/monomer complex. Positively charged poly[2-(dimethylamino)ethyl methacrylate] (PDM) was prepared when DM monomers polymerized in aqueous solution. Self-assembly between PDM and HA was driven by electrostatic interaction, and HA/PDM complex colloid particles were formed in the aqueous medium. The HA/PDM complex structure was characterized by Fourier transform-infrared (FTIR) spectroscopy. The self-assembly behavior between HA and PDM, and the influence of polymerization time on HA/PDM complex colloid particle size, were investigated by dynamic laser scattering (DLS). Morphologies of the colloid particles were characterized by transmission electron microscopy (TEM). The influence of pH on the size and zeta potential of the colloid particles was investigated, and the emulsification of the colloid particles was preliminarily explored. The results showed that no HA/DM complex aggregates were formed before the polymerization of DM monomers. Spherical HA/PDM particles were spontaneously formed through electrostatic interaction between HA and PDM, coinciding with the gradual polymerization of DM. Particle sizes gradually decreased and stabilized with increasing polymerization time. The HA/PDM particles were pH sensitive and possessed improved emulsification properties compared with uncomplexed HA and PDM.
- Hyaluronic acid,
- Poly[2-(dimethylamino)ethyl methacrylate],
- Electrostatic interaction,
- Self-assembly,
- Colloid particle,
- Emulsification
1. [1]
  
  (1) Kötz, J.; Kosmella, S.; Beitz, T. Prog. Polym. Sci. 2001, 26 (8),1199. doi: 10.1016/S0079-6700(01)00016-8
2. [2]
  (2) Zintchenko, A.; Dautzenberg, H.; Tauer, K.; Khrenov, V.Langmuir 2002, 18 (4), 1386. doi: 10.1021/la011267u
3. [3]
  (3) Dautzenberg, H. Macromolecules 1997, 30 (25), 7810.doi: 10.1021/ma970803f
4. [4]
  (4) Kamimura, M.; Kim, J. O.; Kabanov, A. V.; Bronich, T. K.;Nagasaki, Y. J. Control. Release 2012, 160 (3), 486. doi: 10.1016/j.jconrel.2012.04.027
5. [5]
  (5) Harada, A.; Kataoka, K. Science 1999, 283 (5398), 65. doi: 10.1126/science.283.5398.65
6. [6]
  (6) Cheng, Z. Y.; Ren, B. Y.; Gao, M.; Liu, X. X.; Tong, Z.Macromolecules 2007, 40 (21), 7638. doi: 10.1021/ma071072e
7. [7]
  (7) Liu, Z. H.; Shang, Y. Z.; Huang, Y. M.; Peng, C. J.; Liu, H. L.Acta Phys. -Chim. Sin. 2011, 27 (5), 1135. [刘振海, 尚亚卓,黄永民, 彭昌军, 刘洪来. 物理化学学报, 2011, 27 (5), 1135.]doi: 10.3866/PKU.WHXB20110406
8. [8]
  (8) Morfin, I.; Buhler, E.; Cousin, F.; Grillo, I.; Boué, F.Biomacromolecules 2011, 12 (4), 859. doi: 10.1021/bm100861g
9. [9]
  (9) De la Fuente, M.; Seijo, B.; Alonso, M. J. Macromol. Biosci.2008, 8 (5), 441.
10. [10]
  (10) Cai, H.; Ni, C. H.; Zhang, L. P. Eur. J. Pharm. Sci. 2012, 45 (1-2), 43. doi: 10.1016/j.ejps.2011.10.020
11. [11]
  (11) Yang, J. S.; Chen, S. B.; Fang, Y. Carbohyd. Polym. 2009, 75 (2), 333. doi: 10.1016/j.carbpol.2008.07.037
12. [12]
  (12) Boddohi, S.; Moore, N.; Johnson, P. A.; Kipper, M. J.Biomacromolecules 2009, 10 (6), 1402. doi: 10.1021/bm801513e
13. [13]
  (13) Hu, Y.; Jiang, X. Q.; Ding, Y.; Chen, Q.; Yang, C. Z. Adv. Mater.2004, 16 (11), 934.
14. [14]
  (14) Ding, Y.; Chen, Q.; Qian, H. Q.; Chen, Y.;Wu,W.; Hu, Y.;Jiang, X. Q. Macromol. Biosci. 2009, 9 (12), 1272. doi: 10.1002/mabi.v9:12
15. [15]
  (15) Hu, Y.; Chen, Y.; Chen, Q.; Zhang, L. Y.; Jiang, X. Q.; Yang, C.Z. Polymer 2005, 46 (26), 12703. doi: 10.1016/j.polymer.2005.10.110
16. [16]
  (16) Guo, R.; Zhang, L. Y.; Jiang, Z. P.; Cao, Y.; Ding, Y.; Jiang, X.Q. Biomacromolecules 2007, 8 (3), 843. doi: 10.1021/bm060906i
17. [17]
  (17) Gatej, I.; Popa, M.; Rinaudo, M. Biomacromolecules 2005, 6 (1), 61. doi: 10.1021/bm040050m
18. [18]
  (18) Lee, H.; Lee, K.; Park, T. G. Bioconjugate Chem. 2008, 19 (6),1319. doi: 10.1021/bc8000485
19. [19]
  (19) Tanaka, N.; Yoshiike, Y.; Yoshiyama, C.; Kitaoka, T. Carbohyd.Polym. 2010, 82 (1), 100. doi: 10.1016/j.carbpol.2010.04.028
20. [20]
  (20) Xu, J.; Ai, L.; Bai, H. Y.; Jiang, J. Q.; Xia,W. S.; Liu, X. Y.Polymer Bulletin 2011, No. 2, 78. [徐晶, 艾玲, 白绘宇,江金强, 夏文水, 刘晓亚. 高分子通报, 2011, No. 2, 78.]
21. [21]
  (21) Lenormand, H.; Deschrevel, B.; Vincent, J. Carbohyd. Polym.2010, 82 (3), 887. doi: 10.1016/j.carbpol.2010.06.011
22. [22]
  (22) Xu, J.; Bai, H. Y.; Yi, C. L.; Luo, J.; Yang, C.; Xia,W. S.; Liu,X. Y. Carbohyd. Polym. 2011, 86 (2), 678. doi: 10.1016/j.carbpol.2011.05.006
23. [23]
  (23) Tao, Y. H.; Xu, J.; Chen, M. Q.; Bai, H. Y.; Liu, X. Y. Carbohyd.Polym. 2012, 88 (1), 118. doi: 10.1016/j.carbpol.2011.11.075
24. [24]
  (24) Tan, Y.; Xu, K.; Liu, C.; Li, Y.; Lu, C.;Wang, P. Carbohyd.Polym. 2012, 88 (4), 1358. doi: 10.1016/j.carbpol.2012.02.018
25. [25]
  (25) Yusoff, A.; Murray, B. S. Food Hydrocolloids 2011, 25 (1), 42.doi: 10.1016/j.foodhyd.2010.05.004
26. [26]
  (26) Gharsallaoui, A.; Yamauchi, K.; Chambin, O.; Cases, E.; Saurel,R. Carbohyd. Polym. 2010, 80 (3), 820.
27. [27]
  (27) Tømmeraas, K.; Mellergaard, M.; Malle, B. M.; Skagerlind, P.Carbohyd. Polym. 2011, 85 (1), 178.
28. [28]
  (28) Van deWetering, P.; Zuidam, N. J.; Van Steenbergen, M. J.; Vander Houwen, O. A. G. J.; Underberg,W. J. M.; Hennink,W. E.Macromolecules 1998, 31 (23), 8065.
29. [29]
  (29) Wu, Y.; Guo, J.; Yang,W. L.;Wang, C. C.; Fu, S. K. Polymer2006, 47 (15), 5289.
30. [30]
  (30) Zhao, Y. Q.; Fei, F.; Yi, C. L.; Jiang, J. Q.; Luo, J.; Liu, X. Y.Acta Phys. -Chim. Sin. 2010, 26 (12), 3233. [赵艳琼, 费凡,易成林, 江金强, 罗静, 刘晓亚. 物理化学学报, 2010, 26
31. [31]
  (12), 3233.] doi: 10.3866/PKU.WHXB20101217
32. [32]
  (31) Cowman, M. K.; Matsuoka, S. Carbohyd. Res. 2005, 340 (5),805.
33. [33]
  (32) Akiyama, E.; Kashimoto, A.; Fukuda, K.; Hotta, H.; Suzuki, T.;Kitsuki, T. J. Colloid Interface Sci. 2005, 282 (2), 452.
34. [34]
  (33) Zinoviadou, K. G.; Scholten, E.; Moschakis, T.; Biliaderis, C. G.Int. Dairy J. 2012, 26 (1), 98.
35. [35]
  (34) Amalvy, J. I.; Armes, S. P.; Binks, B. P.; Rodrigues, J. A.; Unali,G. F. Chem. Commun. 2003, 1827.
36. [36]
  (35) Yi, C. L.; Yang, Y. Q.; Zhu, Y.; Liu, N.; Liu, X. Y.; Lou, J.;Jiang, M. Langmuir 2012, 28 (25), 9218.
1. [1]
  Jin Tong , Shuyan Yu . Crystal Engineering for Supramolecular Chirality. University Chemistry, 2024, 39(3): 86-93. doi: 10.3866/PKU.DXHX202308113
2. [2]
  Ruoxi Sun , Yiqian Xu , Shaoru Rong , Chunmiao Han , Hui Xu . The Enchanting Collision of Light and Time Magic: Exploring the Footprints of Long Afterglow Lifetime. University Chemistry, 2024, 39(5): 90-97. doi: 10.3866/PKU.DXHX202310001
3. [3]
  Shihui Shi , Haoyu Li , Shaojie Han , Yifan Yao , Siqi Liu . Regioselectively Synthesis of Halogenated Arenes via Self-Assembly and Synergistic Catalysis Strategy. University Chemistry, 2024, 39(5): 336-344. doi: 10.3866/PKU.DXHX202312002
4. [4]
  Xiaofei NIU , Ke WANG , Fengyan SONG , Shuyan YU . Self-assembly of [Pd₆(L)₄]⁸⁺-type macrocyclic complexes for fluorescent sensing of HSO₃^-. Chinese Journal of Inorganic Chemistry, 2024, 40(7): 1233-1242. doi: 10.11862/CJIC.20240057
5. [5]
  Jinghua Wang , Yanxin Yu , Yanbiao Ren , Yesheng Wang . Integration of Science and Education: Investigation of Tributyl Citrate Synthesis under the Promotion of Hydrate Molten Salts for Research and Innovation Training. University Chemistry, 2024, 39(11): 232-240. doi: 10.3866/PKU.DXHX202402057
6. [6]
  Zijian Zhao , Yanxin Shi , Shicheng Li , Wenhong Ruan , Fang Zhu , Jijun Jiang . A New Exploration of the Preparation of Polyacrylic Acid by Free Radical Polymerization Based on the Concept of Green Chemistry. University Chemistry, 2024, 39(5): 315-324. doi: 10.3866/PKU.DXHX202311094
7. [7]
  Ping Song , Nan Zhang , Jie Wang , Rui Yan , Zhiqiang Wang , Yingxue Jin . Experimental Teaching Design on Synthesis and Antitumor Activity Study of Cu-Pyropheophorbide-a Methyl Ester. University Chemistry, 2024, 39(6): 278-286. doi: 10.3866/PKU.DXHX202310087
8. [8]
  Peng XU , Shasha WANG , Nannan CHEN , Ao WANG , Dongmei YU . Preparation of three-layer magnetic composite Fe₃O₄@polyacrylic acid@ZiF-8 for efficient removal of malachite green in water. Chinese Journal of Inorganic Chemistry, 2024, 40(3): 544-554. doi: 10.11862/CJIC.20230239
9. [9]
  Lirui Shen , Kun Liu , Ying Yang , Dongwan Li , Wengui Chang . Synthesis and Application of Decanedioic Acid-N-Hydroxysuccinimide Ester: Exploration of Teaching Reform in Comprehensive Applied Chemistry Experiment. University Chemistry, 2024, 39(8): 212-220. doi: 10.3866/PKU.DXHX202312035
10. [10]
  Meijin Li , Xirong Fu , Xue Zheng , Yuhan Liu , Bao Li . The Marvel of NAD⁺: Nicotinamide Adenine Dinucleotide. University Chemistry, 2024, 39(9): 35-39. doi: 10.12461/PKU.DXHX202401027
11. [11]
  Junke LIU , Kungui ZHENG , Wenjing SUN , Gaoyang BAI , Guodong BAI , Zuwei YIN , Yao ZHOU , Juntao LI . Preparation of modified high-nickel layered cathode with LiAlO₂/cyclopolyacrylonitrile dual-functional coating. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1461-1473. doi: 10.11862/CJIC.20240189
12. [12]
  Qingying Gao , Tao Luo , Jianyuan Su , Chaofan Yu , Jiazhu Li , Bingfei Yan , Wenzuo Li , Zhen Zhang , Yi Liu . Refinement and Expansion of the Classic Cinnamic Acid Synthesis Experiment. University Chemistry, 2024, 39(5): 243-250. doi: 10.3866/PKU.DXHX202311074
13. [13]
  Yongming Guo , Jie Li , Chaoyong Liu . Green Improvement and Educational Design in the Synthesis and Characterization of Silver Nanoparticles. University Chemistry, 2024, 39(3): 258-265. doi: 10.3866/PKU.DXHX202309057
14. [14]
  Yunchao Li , Shanying Chen , Ke Qi , Kangning Huo , Shuxin Li , Jingyi Li , Ying Wei , Louzhen Fan . A New Colloid Electrophoresis Experiment Incorporating Characteristics of Inquiry Learning and Ideological and Political Education. University Chemistry, 2024, 39(2): 47-51. doi: 10.3866/PKU.DXHX202308063
15. [15]
  Shanying Chen , Kangning Huo , Ke Qi , Jingyi Li , Shuxin Li , Yunchao Li . A Novel Colloid Electrophoresis Experiment with the Characteristics of Resource Recycling and Inquiry-Driven Experimental Design. University Chemistry, 2024, 39(5): 274-286. doi: 10.3866/PKU.DXHX202311067
16. [16]
  Feng Liang , Desheng Li , Yuting Jiang , Jiaxin Dong , Dongcheng Liu , Xingcan Shen . Method Exploration and Instrument Innovation for the Experiment of Colloid ζ Potential Measurement by Electrophoresis. University Chemistry, 2024, 39(5): 345-353. doi: 10.3866/PKU.DXHX202312009
17. [17]
  Keying Qu , Jie Li , Ziqiu Lai , Kai Chen . Unveiling the Mystery of Chirality from Tartaric Acid. University Chemistry, 2024, 39(9): 369-378. doi: 10.12461/PKU.DXHX202310091
18. [18]
  Fengqiao Bi , Jun Wang , Dongmei Yang . Specialized Experimental Design for Chemistry Majors in the Context of “Dual Carbon”: Taking the Assembly and Performance Evaluation of Zinc-Air Fuel Batteries as an Example. University Chemistry, 2024, 39(4): 198-205. doi: 10.3866/PKU.DXHX202311069
19. [19]
  Donghui PAN , Yuping XU , Xinyu WANG , Lizhen WANG , Junjie YAN , Dongjian SHI , Min YANG , Mingqing CHEN . Preparation and in vivo tracing of ⁶⁸Ga-labeled PM_2.5 mimetic particles for positron emission tomography imaging. Chinese Journal of Inorganic Chemistry, 2024, 40(4): 669-676. doi: 10.11862/CJIC.20230468
20. [20]
  Lina Liu , Xiaolan Wei , Jianqiang Hu . Exploration of Subject-Oriented Undergraduate Comprehensive Chemistry Experimental Teaching Based on the “STS Concept”: Taking the Experiment of Gold Nanoparticles as an Example. University Chemistry, 2024, 39(10): 337-343. doi: 10.12461/PKU.DXHX202405112

Get Citation

PDF

XML

Metrics

PDF Downloads(721)
Abstract views(853)
HTML views(25)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142