Citation: ZOU Hui, NI Xiang, PENG Sheng-Lin, OUYANG Jun, CHEN Yu, OUYANG Fang-Ping. First-Principles Study of Graphene-Based Biomolecular Sensor[J]. Acta Physico-Chimica Sinica, ;2013, 29(02): 250-254. doi: 10.3866/PKU.WHXB201211141 shu

First-Principles Study of Graphene-Based Biomolecular Sensor

1.
1 School of Physics and Electronics, Central South University, Changsha 410083, P. R. China;
2 Powder Metallurgy Research Institute, and State Key Laboratory of Powder Metallurgy, Changsha 410083, P. R. China

Received Date: 8 September 2012
Available Online: 14 November 2012
Fund Project: 国家自然科学基金(51272291, 21103232, 11104356) (51272291, 21103232, 11104356)湖南省自然科学基金(11JJ4001) (11JJ4001)中国博士后科学基金(2012M511399) (2012M511399) 湖南省科技计划(2012RS4009) (2012RS4009)中南大学博士后科学基金(201202025)资助项目 (201202025)

First-principles calculations were applied to design and study the electron transport behavior of a biomolecular sensor with graphene-based electrodes. It is shown that the designed biosensor is capable of distinguishing different nucleotide molecules such as cytosine, methylcytosine, and hydroxymethylcytosine. The current was seen to change by nearly one order of magnitude, while molecules passed through the device individually. The resolution capacity of the present device was primarily determined by the interactions and specific configurations of two adjacent single-stranded desoxyribonucleic acid (DNA) molecules and their specific configurations. This graphene-based biosensor was proved to be effective and efficient in detecting and distinguishing different DNA molecules, which provides a new potential method to pinpoint exactly varietal base molecules in DNAchains for the genetic information.
- First-principles,
- Graphene,
- Methylcytosine,
- Hydroxymethylcytosine,
- Transverse conductance
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