Citation: HUANG Yang-Yu, YANG Xiu-Feng, LI Hao-Tian, JI Xiao-Feng, CHENG Hong-Li, ZHAO Yun-Jie, GUO Da-Chuan, LI Lin, LIU Shi-Yong. Protein-RNA Interaction Interface Prediction and Design[J]. Acta Physico-Chimica Sinica, ;2012, 28(10): 2390-2400. doi: 10.3866/PKU.WHXB201209111 shu

Protein-RNA Interaction Interface Prediction and Design

1.
Biomolecular Physics and Modeling Group, Department of Physics, Huazhong University of Science and Technology, Wuhan 430074, P. R. China

Received Date: 23 August 2012
Available Online: 11 September 2012
Fund Project: 国家自然科学基金(31100522) (31100522) 国家高技术研究发展计划(2012AA020402) (2012AA020402) 高等学校博士学科点专项科研基金(20110142120038)资助. (20110142120038)

RNA-protein interactions play key roles in many biological processes. The three dimensional (3D) structure of protein-RNA complexes can be determined experimentally by structural biologists. The recognition between protein and RNA can be understood from the 3D atomic structure. However, the structure determination of protein-RNA complexes by experimental methods is often difficult and costly, and limited to the binding strength. Thus, the prediction and design of protein-RNA complex structures is important in biological medical research. In this review, we will discuss the recent progress in protein-RNA interface prediction and design, which includes the following aspects: (1) protein-RNA docking and the conformational change on binding; (2) the recognition mechanism of protein-RNA binding; (3) the molecular design based on the protein-RNA interface. Improvement of the protein-RNA docking al rithm will help us annotate a large number of proteins and RNA with unknown function, and molecular design based on macromolecular interactions will be useful in drug design.
- Protein-RNA interaction,
- Molecular docking,
- Interface design,
- Complex structure prediction
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