Citation: WEN Wen, GAO Xiao-Ya, SONG Zhi-Ying, HAN Dong, WANG Juan, ZHU Mei-Xia, ZHANG Ai-Ping. Preparation of Magnetic Targeted Fe₃O₄-TiO₂Nanoparticles and Their Photocatalytic Killing Effect on Hepatoma Carcinoma Cells[J]. Acta Physico-Chimica Sinica doi: 10.3866/PKU.WHXB201206151 shu

Preparation of Magnetic Targeted Fe₃O₄-TiO₂Nanoparticles and Their Photocatalytic Killing Effect on Hepatoma Carcinoma Cells

1.
College of Pharmacy, Shanxi Medical University, Taiyuan 030001, P. R. China

Received Date: 17 April 2012
Available Online: 15 June 2012
Fund Project: 山西省自然科学基金(2010011048-1) (2010011048-1) 太原市2012 年科学技术发展计划大学生创新创业项目(120164073) (120164073)

Fe₃O₄-TiO₂ nanoparticles with different doped amounts of Fe₃O₄ were prepared by three sol-gel methods at low temperature. They were characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), Fourier transform infrared (FTIR) spectroscopy, ultraviolet-visible (UV-Vis) spectroscopy, fluorescence spectroscopy (FS), and magnetic performance. The nanoparticles which had uniform coating, od dispersion, excellent magnetism, and high photocatalytic activity were screened. The survival rates of hepatoma carcinoma cells (HepG2) were measured by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) cell proliferation assay, and the photo-killing effect of screened Fe₃O₄-TiO₂ nanoparticles on HepG2 cells was investigated in different external magnetic fields. The results indicated that the core-shell structure 5% (mass fraction) Fe₃O₄-TiO₂ nanoparticles prepared by the third method displayed od dispersion in suspension, high photocatalytic activity, and excellent magnetic responsivity. The average particle size of the 5%Fe₃O₄-TiO₂ particles was 50 nm. Meanwhile, the photoresponsive range of TiO₂ was extended to 444 nm. In the external magnetic fields, the Fe₃O₄-TiO₂ nanoparticles excited either by ultraviolet or visible light showed no obvious difference on killing effect, while in both cases had a higher killing effect than that of nano-TiO₂. Furthermore, the killing effect was enhanced with the increased magnetic field strength in the range of 0-1.0 T.
- Magnetic targeting,
- Fe₃O₄-TiO₂ nanoparticles,
- HepG2 cell,
- Photocatalysis,
- Killing effect
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Preparation of Magnetic Targeted Fe3O4-TiO2Nanoparticles and Their Photocatalytic Killing Effect on Hepatoma Carcinoma Cells

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通讯作者: 陈斌, bchen63@163.com

Preparation of Magnetic Targeted Fe₃O₄-TiO₂Nanoparticles and Their Photocatalytic Killing Effect on Hepatoma Carcinoma Cells