Citation: ZHANG Xiao, YANG Rong, WANG Chen, HENG Cheng-Lin. Cell Biocompatibility of Functionalized Graphene Oxide[J]. Acta Physico-Chimica Sinica, ;2012, 28(06): 1520-1524. doi: 10.3866/PKU.WHXB201203131 shu

Cell Biocompatibility of Functionalized Graphene Oxide

ZHANG Xiao ^1,2 ,
YANG Rong ^2, ,
WANG Chen ² ,
HENG Cheng-Lin ^1,

1.
1. Key Laboratory of Cluster Science of Ministry of Education, School of Physics, Beijing Institute of Technology, Beijing 100081, P. R. China;
2. Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Chinese Academy of Sciences, National Center for Nanoscience and Technology, Beijing 100190, P. R. China

Received Date: 25 November 2011
Available Online: 13 March 2012
Fund Project: 国家自然科学基金(20911130229, 21073047) (20911130229, 21073047)中国科学院知识创新工程重要方向项目(KJCX2.YW.M15)资助 (KJCX2.YW.M15)

We report on synthesis of nanoscale graphene oxide (N ) by modified Hummers’method. Synthesized N particles were surface functionalized by attaching carboxylic acid and polyethylene glycol groups to render them soluble in cell culture medium. The structures and properties of functionalized N were characterized by transmission electron microscopy (TEM), Fourier transform infrared (FTIR) spectroscopy, and zeta potential analyzer. Cell viability studies show that PEG-modified N particles are highly soluble and incur almost no cytotoxicity to A549 cells, which suggest a great potential for the use of N in various biomedical applications.
- Graphene oxide,
- Nanomaterials,
- Biocompatibility,
- Surface functionalization
1. [1]
  (1) Geim, A. K.; Novoselov, K. S. Nat. Mater. 2007, 6, 183. 10.1038/nmat1849
2. [2]
  (2) Rozhkov, A. V.; Giavaras, G.; Bliokh, Y. P.; Freilikher, V.; Nori, F. Phys. Rep. 2011, 503, 77. 10.1016/j.physrep.2011.02.002
3. [3]
  (3) Novoselov, K. S.; Geim, A. K.; Morozov, S. V.; Jiang, D.; Zhang, Y.; Dubonos, S. V.; Gri rieva, I. V.; Firsov, A. A. Science 2004, 306, 666. 10.1126/science.1102896
4. [4]
  (4) Xu, D.; Zhou, N. L.; Shen, J. Chem. J. Chin. U. 2010, 31 (12), 2354. [徐东, 周宁琳, 沈健. 高等学校化学学报, 2010, 31 (12), 2354.]
5. [5]
  (5) Gu, X. G.; Yang, G.; Zhang, G. X.; Zhang, D. Q.; Zhu, D. B. ACS Appl. Mat. Interfaces 2011, 3, 1175. 10.1021/am2000104
6. [6]
  (6) Schniepp, H. C.; Li, J. L.; McAllister, M. J.; Sai, H.; Herrera-Alonso, M.; Adamson, D. H.; Prud'homme, R. K.; Car, R.; Saville, D. A.; Aksay, I. A. J. Phys. Chem. B 2006, 110, 8535.
7. [7]
  (7) Zhang, Q.; He, Y. Q.; Chen, X. G.; Hu, D. H.; Li, L. L.; Yi, T. Chin. Sci. Bull. 2010, 55, 620. [张琼, 贺蕴秋, 陈小刚, 胡栋虎, 李林江, 尹婷. 科学通报, 2010, 55, 620.]
8. [8]
  (8) Liu, Y.; Yu, D. S.; Zeng, C.; Miao Z. C.; Dai, L. M. Langmuir 2010, 26, 6158. 10.1021/la100886x
9. [9]
  (9) Yan, X. B.; Chen, J. T.; Yang, J.; Xue, Q. J.; Miele, P. ACS Appl. Mat. Interfaces 2010, 2, 2521. 10.1021/am100293r
10. [10]
  (10) Zhang, L. M.; Xia, J. G.; Zhao, Q. H.; Zhang, Z. J. Small 2010, 4, 537.
11. [11]
  (11) Yang, X. Y.; Zhang, X. Y.; Liu, Z. F.; Ma, Y. F.; Huang, Y.; Chen, Y. S. J. Phys. Chem. C 2008, 112, 17554. 10.1021/jp806751k
12. [12]
  (12) Yang, K.; Zhang, S.; Zhang, G. X.; Sun, X. M.; Lee, S. T.; Liu, Z. Nano Lett. 2010, 10, 3318. 10.1021/nl100996u
13. [13]
  (13) Chang, Y. L.; Yang, S. T.; Liu, J. H.; Dong, E.; Wang, Y. W.; Cao, A.; Liu, Y. F.; Wang, H. F. Toxicol. Lett. 2011, 200, 201. 10.1016/j.toxlet.2010.11.016
14. [14]
  (14) Zhang, S.; Yang, K.; Feng, L. Z.; Liu, Z. Carbon, 2011, 49, 4040. 10.1016/j.carbon.2011.05.056
15. [15]
  (15) Dikin, D. A.; Stankovich, S.; Zimney, E. J.; Piner, R. D.; Dommett, G. H. B.; Evmenenko, G.; Nguyen, S. T.; Ruoff, R. S. Nature 2007, 448, 457. 10.1038/nature06016
16. [16]
  (16) Stankovich, S.; Dikin, D. A.; Dommett, G. H. B.; Kohlhaas, K. M.; Zimney, E. J.; Stach, E. A.; Piner, R. D.; Nguyen, S. T.; Ruoff, R. S. Nature 2006, 442, 282. 10.1038/nature04969
17. [17]
  (17) Li, D.; Müller, M. B.; Gilje, S.; Kaner, R. B.; Wallace, G. G. Nat. Nanotechnol. 2008, 3, 101. 10.1038/nnano.2007.451
18. [18]
  (18) Hummers, Jr. W. S.; Offeman, R. E. J. Am. Chem. Soc. 1958, 80, 1339. 10.1021/ja01539a017
19. [19]
  (19)Hermanson, G. T. Bioconjugate techniques. http://www.sciencedirect.com/science/ book/9780123705013
20. [20]
  (20) Fan, X. B.; Peng, W. C.; Li, Y.; Li, X. Y.; Wang, S. L.; Zhang, G. L.; Zhang, F. B. Adv. Mater 2008, 20, 4490. 10.1002/adma.200801306
21. [21]
  (21) Rana, V. K.; Choi, M. C.; Kong, J. Y.; Kim, G. Y.; Kim, M. J.; Kim, S. H.; Mishra, S.; Singh, R. P.; Ha, C. S. Macromol. Mater. Eng. 2011, 296,131. 10.1002/mame.201000307
22. [22]
  (22) Wang, G. X; Wang, B.; Park, J.; Yang, J.; Shen, X. P.; Yao, J. Carbon 2009, 47, 68. 10.1016/j.carbon.2008.09.002
23. [23]
  (23) Shan, C. S.; Yang, H. F.; Han, D. X.; Zhang, Q. X.; Ivaska, A.; Niu, L. Langmuir 2009, 25, 12030. 10.1021/la903265p
24. [24]
  (24) Si, Y. C.; Samulski, E. T. Nano Lett. 2008, 8, 1679. 10.1021/nl080604h
25. [25]
  (25) Liu, Z.; Robinson, J. T.; Sun, X. M.; Dai, H. J. J. Am. Chem. Soc. 2008, 130, 10876. 10.1021/ja803688x
26. [26]
  (26) Sun, X. M.; Liu, Z.; Welsher, K.; Robinson, J. T.; odwin, A.; Zaric, S.; Dai, H. J. Nano Res. 2008, 1, 203. 10.1007/s12274-008-8021-8
27. [27]
  (27) Nguyen, T. T. T.; Tran, E.; Nguyen, T. H.; Do, P. T.; Huynh, T. H.; Huynh, H. Carcin. 2004, 25, 647.
28. [28]
  (28) Wu, H. H.; Yang, R.; Song, B. M.; Han, Q. S.; Li, J. Y.; Zhang, Y.; Fang, Y.; Tenne, R. Wang, C. ACS Nano 2011, 5, 1276. 10.1021/nn102941b
1. [1]
  Simin Fang , Wei Huang , Guanghua Yu , Cong Wei , Mingli Gao , Guangshui Li , Hongjun Tian , Wan Li . Integrating Science and Education in a Comprehensive Chemistry Design Experiment: The Preparation of Copper(I) Oxide Nanoparticles and Its Application in Dye Water Remediation. University Chemistry, 2024, 39(8): 282-289. doi: 10.3866/PKU.DXHX202401023
2. [2]
  Zunyuan Xie , Lijin Yang , Zixiao Wan , Xiaoyu Liu , Yushan He . Exploration of the Preparation and Characterization of Nano Barium Titanate and Its Application in Inorganic Chemistry Laboratory Teaching. University Chemistry, 2024, 39(4): 62-69. doi: 10.3866/PKU.DXHX202310137
3. [3]
  Juan Yuan , Bin Zhang , Jinping Wu , Mengfan Wang . Design of a Comprehensive Experiment on Preparation and Characterization of Cu₂(Salen)₂ Nanomaterials with Two Distinct Morphologies. University Chemistry, 2024, 39(10): 420-425. doi: 10.3866/PKU.DXHX202402014
4. [4]
  Zhuo WANG , Junshan ZHANG , Shaoyan YANG , Lingyan ZHOU , Yedi LI , Yuanpei LAN . Preparation and photocatalytic performance of CeO₂-reduced graphene oxide by thermal decomposition. Chinese Journal of Inorganic Chemistry, 2024, 40(9): 1708-1718. doi: 10.11862/CJIC.20240067
5. [5]
  Zeyu XU , Anlei DANG , Bihua DENG , Xiaoxin ZUO , Yu LU , Ping YANG , Wenzhu YIN . Evaluation of the efficacy of graphene oxide quantum dots as an ovalbumin delivery platform and adjuvant for immune enhancement. Chinese Journal of Inorganic Chemistry, 2024, 40(6): 1065-1078. doi: 10.11862/CJIC.20240099
6. [6]
  Wenjun Zheng . Application in Inorganic Synthesis of Ionic Liquids. University Chemistry, 2024, 39(8): 163-168. doi: 10.3866/PKU.DXHX202401020
7. [7]
  Yunting Shang , Yue Dai , Jianxin Zhang , Nan Zhu , Yan Su . Something about RGO (Reduced Graphene Oxide). University Chemistry, 2024, 39(9): 273-278. doi: 10.3866/PKU.DXHX202306050
8. [8]
  Zhihuan XU , Qing KANG , Yuzhen LONG , Qian YUAN , Cidong LIU , Xin LI , Genghuai TANG , Yuqing LIAO . Effect of graphene oxide concentration on the electrochemical properties of reduced graphene oxide/ZnS. Chinese Journal of Inorganic Chemistry, 2024, 40(7): 1329-1336. doi: 10.11862/CJIC.20230447
9. [9]
  Yunhao Zhang , Yinuo Wang , Siran Wang , Dazhen Xu . Progress in Selective Construction of Functional Aromatics from Nitrogenous Cycloalkanes. University Chemistry, 2024, 39(11): 136-145. doi: 10.3866/PKU.DXHX202401083
10. [10]
  Guangming YIN , Huaiyao WANG , Jianhua ZHENG , Xinyue DONG , Jian LI , Yi'nan SUN , Yiming GAO , Bingbing WANG . Preparation and photocatalytic degradation performance of Ag/protonated g-C₃N₄ nanorod materials. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1491-1500. doi: 10.11862/CJIC.20240086
11. [11]
  Xiufang Wang , Donglin Zhao , Kehua Zhang , Xiaojie Song . “Preparation of Carbon Nanotube/SnS₂ Photoanode Materials”: A Comprehensive University Chemistry Experiment. University Chemistry, 2024, 39(4): 157-162. doi: 10.3866/PKU.DXHX202308025
12. [12]
  Yinyin Qian , Rui Xu . Utilizing VESTA Software in the Context of Material Chemistry: Analyzing Twin Crystal Nanostructures in Indium Antimonide. University Chemistry, 2024, 39(3): 103-107. doi: 10.3866/PKU.DXHX202307051
13. [13]
  Junli Liu . Practice and Exploration of Research-Oriented Classroom Teaching in the Integration of Science and Education: a Case Study on the Synthesis of Sub-Nanometer Metal Oxide Materials and Their Application in Battery Energy Storage. University Chemistry, 2024, 39(10): 249-254. doi: 10.12461/PKU.DXHX202404023
14. [14]
  Yan LIU , Jiaxin GUO , Song YANG , Shixian XU , Yanyan YANG , Zhongliang YU , Xiaogang HAO . Exclusionary recovery of phosphate anions with low concentration from wastewater using a CoNi-layered double hydroxide/graphene electronically controlled separation film. Chinese Journal of Inorganic Chemistry, 2024, 40(9): 1775-1783. doi: 10.11862/CJIC.20240043
15. [15]
  Heng Chen , Longhui Nie , Kai Xu , Yiqiong Yang , Caihong Fang . 两步焙烧法制备大比表面积和结晶性增强超薄g-C₃N₄纳米片及其高效光催化产H₂O₂. Acta Physico-Chimica Sinica, 2024, 40(11): 2406019-. doi: 10.3866/PKU.WHXB202406019
16. [16]
  Meng Lin , Hanrui Chen , Congcong Xu . Preparation and Study of Photo-Enhanced Electrocatalytic Oxygen Evolution Performance of ZIF-67/Copper(I) Oxide Composite: A Recommended Comprehensive Physical Chemistry Experiment. University Chemistry, 2024, 39(4): 163-168. doi: 10.3866/PKU.DXHX202308117
17. [17]
  Weihan Zhang , Menglu Wang , Ankang Jia , Wei Deng , Shuxing Bai . 表面硫物种对钯-硫纳米片加氢性能的影响. Acta Physico-Chimica Sinica, 2024, 40(11): 2309043-. doi: 10.3866/PKU.WHXB202309043
18. [18]
  Nana Wang , Gaosheng Zhang , Huosheng Li , Tangfu Xiao . Discussion on the Teaching Reform of Environmental Functional Materials within the Context of “Double First-Class” Initiative: Emphasizing the Integration of Industry, Academia, Research, and Application. University Chemistry, 2024, 39(6): 137-144. doi: 10.3866/PKU.DXHX202312010
19. [19]
  Cunming Yu , Dongliang Tian , Jing Chen , Qinglin Yang , Kesong Liu , Lei Jiang . Chemistry “101 Program” Synthetic Chemistry Experiment Course Construction: Synthesis and Properties of Bioinspired Superhydrophobic Functional Materials. University Chemistry, 2024, 39(10): 101-106. doi: 10.12461/PKU.DXHX202408008
20. [20]
  Zhenlin Zhou , Siyuan Chen , Yi Liu , Chengguo Hu , Faqiong Zhao . A New Program of Voltammetry Experiment Teaching Based on Laser-Scribed Graphene Electrode. University Chemistry, 2024, 39(2): 358-370. doi: 10.3866/PKU.DXHX202308049

Get Citation

PDF

XML

Metrics

PDF Downloads(1409)
Abstract views(3273)
HTML views(95)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142