Citation: ZHANG Xiao, YANG Rong, WANG Chen, HENG Cheng-Lin. Cell Biocompatibility of Functionalized Graphene Oxide[J]. Acta Physico-Chimica Sinica, ;2012, 28(06): 1520-1524. doi: 10.3866/PKU.WHXB201203131 shu

Cell Biocompatibility of Functionalized Graphene Oxide

ZHANG Xiao ^1,2 ,
YANG Rong ^2, ,
WANG Chen ² ,
HENG Cheng-Lin ^1,

1.
1. Key Laboratory of Cluster Science of Ministry of Education, School of Physics, Beijing Institute of Technology, Beijing 100081, P. R. China;
2. Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Chinese Academy of Sciences, National Center for Nanoscience and Technology, Beijing 100190, P. R. China

Received Date: 25 November 2011
Available Online: 13 March 2012
Fund Project: 国家自然科学基金(20911130229, 21073047) (20911130229, 21073047)中国科学院知识创新工程重要方向项目(KJCX2.YW.M15)资助 (KJCX2.YW.M15)

We report on synthesis of nanoscale graphene oxide (N ) by modified Hummers’method. Synthesized N particles were surface functionalized by attaching carboxylic acid and polyethylene glycol groups to render them soluble in cell culture medium. The structures and properties of functionalized N were characterized by transmission electron microscopy (TEM), Fourier transform infrared (FTIR) spectroscopy, and zeta potential analyzer. Cell viability studies show that PEG-modified N particles are highly soluble and incur almost no cytotoxicity to A549 cells, which suggest a great potential for the use of N in various biomedical applications.
- Graphene oxide,
- Nanomaterials,
- Biocompatibility,
- Surface functionalization
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