Citation: QIAO Rui-Rui, ZENG Jian-Feng, JIA Qiao-Juan, DU Jun, SHEN Lin, GAO Ming-Yuan. Magnetic Iron Oxide Nanoparticle——an Important Cornerstone of MR Molecular Imaging of Tumors[J]. Acta Physico-Chimica Sinica, ;2012, 28(05): 993-1011. doi: 10.3866/PKU.WHXB201203023 shu

Magnetic Iron Oxide Nanoparticle——an Important Cornerstone of MR Molecular Imaging of Tumors

  • Received Date: 15 January 2012
    Available Online: 2 March 2012

    Fund Project: 国家重点基础研究发展计划(973) (2011CB935800) (973) (2011CB935800)国家自然科学基金(81090271, 21003135, 20820102035)资助项目 (81090271, 21003135, 20820102035)

  • This review summaries the syntheses and applications of magnetic iron oxide nanocrystals that have been published worldwide. In particular, it discusses the future applications of magnetic iron oxide nanoparticles in molecular imaging of tumors.
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    1. [1]

      (1) Ferlay, J.; Bray, F.; Forman, D; Mathers, C. D; Parkin, D. Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 10. Lyon, France: International Agency for Research on Cancer. Available at: http://globocan.iarc.fr. 2010. Last accessed 8/17/2010. GLOBOCAN 2008.

    2. [2]

      (2) Weissleder, R. Science 2006, 312, 1168.  

    3. [3]

      (3) Weissleder, R.; Pittet, M. J. Nature 2008, 452, 580.  

    4. [4]

      (4) Wagner, V.; Dullaart, A.; Bock, A. K.; Zweck, A. Nat. Biotechnol. 2006, 24, 1211.  

    5. [5]

      (5) Corot, C.; Robert, P.; Idee, J. M.; Port, M. Adv. Drug Deliv. Rev. 2006, 58, 1471.  

    6. [6]

      (6) Briley-Saebo, K.; Bjornerud, A.; Grant, D.; Ahlstrom, H.; Berg, T.; Kindberg, G. M. Cell Tissue Res. 2004, 316, 315.  

    7. [7]

      (7) Qiao, R. R.; Yang, C. H.; Gao, M. Y. J. Mater. Chem. 2009, 19, 6274.  

    8. [8]

      (8) Harisinghani, M. G.; Barentsz, J.; Hahn, P. F.; Deserno, W. M.; Tabatabaei, S.; van de Kaa, C. H.; de la Rosette, J.; Weissleder, R. N. Engl. J. Med. 2003, 348, 2491.  

    9. [9]

      (9) Huh, Y. M.; Jun, Y. W.; Song, H. T.; Kim, S.; Choi, J. S.; Lee, J. H.; Yoon, S.; Kim, K. S.; Shin, J. S.; Suh, J. S.; Cheon, J. J. Am. Chem. Soc. 2005, 127, 12387.  

    10. [10]

      (10) Hu, F. Q.; Wei, L.; Zhou, Z.; Ran, Y. L.; Li, Z.; Gao, M. Y. Adv. Mater. 2006, 18, 2553.  

    11. [11]

      (11) Murakami, H.; Nakashima, N. J. Nanosci. Nanotechnol. 2006, 6, 16.

    12. [12]

      (12) Mikawa, M.; Kato, H.; Okumura, M.; Narazaki, M.; Kanazawa, Y.; Miwa, N.; Shinohara, H. Bioconjugate Chem. 2001, 12, 510.  

    13. [13]

      (13) Jain, P. K.; Lee, K. S.; El-Sayed, I. H.; El-Sayed, M. A. J. Phys. Chem. B 2006, 110, 7238.  

    14. [14]

      (14) Gao, X. H.; Cui, Y. Y.; Levenson, R. M.; Chung, L. W. K.; Nie, S. M. Nat. Biotechnol. 2004, 22, 969.  

    15. [15]

      (15) Jordan, A.; Scholz, R.; Wust, P.; Fähling, H.; Krause, J.; Wlodarczyk, W.; Sander, B.; Vogl, T.; Felix, R. Int. J. Hyperthermia 1997, 13(6), 587.

    16. [16]

      (16) Veiseh, O.; Gunn, J. W.; Zhang, M. Q. Adv. Drug Deliv. Rev. 2010, 62, 284.  

    17. [17]

      (17) Yang, W. Gao, M. Y.; Bai, Y. Nanomaterials and Biotechnologies, 1st ed.; Chemical Industry Press; Beijing, 2005; pp 53-177 [杨文胜, 高明远, 白玉白. 纳米材料与生物技术, 第一版; 化学工业出版社: 北京, 2005; 53-177.]  

    18. [18]

      (18) Degen, C. L.; Poggio, M.; Mamin, H. J.; Rettner, C. T.; Rugar, D. Proc. Natl. Acad. Sci. U. S. A. 2009, 106, 1313.  

    19. [19]

      (19) Fischer, U.; Brinck, U. Practical MR mammography. Stuttgart: Georg Thieme Verlag, 2003.  

    20. [20]

      (20) Qiao, R. R.; Jia, Q. J.; Zeng, J. F.; Gao, M. Y. Acta Biophys. Sinca 2011, 27, 272. [乔瑞瑞, 贾巧娟, 曾剑峰, 高明远. 生物物理学报, 2011, 27, 272.]  

    21. [21]

      (21) De Leon-Rodriguez, L. M.; Lubag, A. J. M.; Malloy, C. R.; Martinez, G. V.; Gillies, R. J.; Sherry, A. D. Accounts Chem. Res. 2009, 42, 948.  

    22. [22]

      (22) Rad, A. M.; Arbab, A. S.; Iskander, A. S. M.; Jiang, Q.; Soltanian-Zadeh, H. J. Magn. Reson. Imaging 2007, 26, 366.  

    23. [23]

      (23) Tanaka, K.; Narita, A.; Kitamura, N.; Uchiyama, W.; Morita, M.; Inubushi, T.; Chujo, Y. Langmuir 2010, 26, 11759.  

    24. [24]

      (24) Heesakkers, R. A. M.; Jager, G. J.; Hovels, A. M.; de Hoop, B.; van den Bosch, H. C. M.; Raat, F.; Witjes, J. A.; Mulders, P. F. A.; van der Kaa, C. H.; Barentsz, J. O. Radiology 2009, 251, 408.  

    25. [25]

      (25) Bee, A.; Massart, R.; Neveu, S. J. Magn. Magn. Mater. 1995, 149, 6.  

    26. [26]

      (26) Rockenberger, J.; Scher, E. C.; Alivisatos, A. P. J. Am. Chem. Soc. 1999, 121, 11595.  

    27. [27]

      (27) Park, S.-J.; Kim, S.; Lee, S.; Khim, Z. G.; Char, K.; Hyeon, T. J. Am. Chem. Soc. 2000, 122, 8581.  

    28. [28]

      (28) Sun, S. H.; Zeng, H. J. Am. Chem. Soc. 2002, 124, 8204.  

    29. [29]

      (29) Sun, S. H.; Zeng, H.; Robinson, D. B.; Raoux, S.; Rice, P. M.; Wang, S. X.; Li, G. X. J. Am. Chem. Soc. 2004, 126, 273.  

    30. [30]

      (30) Jana, N. R.; Chen, Y.; Peng, X. G. Chem. Mater. 2004, 16, 3931.  

    31. [31]

      (31) Park, J.; An, K. J.; Hwang, Y. S.; Park, J. G.; Noh, H. J.; Kim, J. Y.; Park, J. H.; Hwang, N. M.; Hyeon, T. Nat. Mater. 2004, 3, 891.  

    32. [32]

      (32) Lee, J. H.; Huh, Y. M.; Jun, Y.; Seo, J.; Jang, J.; Song, H. T.; Kim, S.; Cho, E. J.; Yoon, H. G.; Suh, J. S.; Cheon, J. Nat. Med. 2007, 13, 95.  

    33. [33]

      (33) Jun, Y.-W.; Seo, J.-W.; Cheon, J. Acc. Chem. Res. 2008, 41, 179.  

    34. [34]

      (34) Jung, C. W.; Jacobs, P. Magn. Reson. Imaging 1995, 13, 661.  

    35. [35]

      (35) Wan, Y. X.; Hussain, S. M.; Krestin,G. P. Eur. J. Radiol. 2001, 11, 2319.  

    36. [36]

      (36) Josephson, L.; Tung, C. H.; Moore, A.; Weissleder, R. Bioconjugate Chem. 1999, 10, 186.  

    37. [37]

      (37) Jun, Y. W.; Huh, Y. M.; Choi, J. S.; Lee, J. H.; Song, H. T.; Kim, S.; Yoon, S.; Kim, K. S.; Shin, J. S.; Suh, J. S.; Cheon, J. J. Am. Chem. Soc. 2005, 127, 5732.  

    38. [38]

      (38) Xie, J.; Chen, K.; Lee, H. Y.; Xu, C. J.; Hsu, A. R.; Peng, S.; Chen, X. Y.; Sun, S. H. J. Am. Chem. Soc. 2008, 130, 7542.  

    39. [39]

      (39) Liu, S. J.; Jia, B.; Qiao, R. R.; Yang, Z.; Yu, Z. L.; Liu, Z. F.; Liu, K.; Shi, J. Y.; Han, O. Y.; Wang, F.; Gao, M. Y. Mol. Pharmceutics 2009, 6, 1074.  

    40. [40]

      (40) Xie,J.; Xu, C.; Kohler, N.; Hou, Y.; Sun, S. Adv. Mater. 2007, 19, 3163.  

    41. [41]

      (41) Bin Na, H.; Lee, I. S.; Seo, H.; Il Park, Y.; Lee, J. H.; Kim, S. W.; Hyeon, T. Chem. Commun. 2007, 5167.

    42. [42]

      (42) Piao, Y.; Park, Y. I.; Lee, N.; Yoo, B.; Kim, B. H.; Choi, S. H.; Hyeon, T. J. Mater. Chem. 2011, 21, 11472.  

    43. [43]

      (43) Robinson, D. B.; Persson, H. H. J.; Zeng, H.; Li, G. X.; Pourmand, N.; Sun, S. H.; Wang, S. X. Langmuir 2005, 21, 3096.  

    44. [44]

      (44) Nitin, N.; LaConte, L. E. W.; Zurkiya, O.; Hu, X.; Bao, G. J. Biol. Inorg. Chem. 2004, 9, 706.

    45. [45]

      (45) Pellegrino, T.; Manna, L.; Kudera, S.; Liedl, T.; Koktysh, D.; Rogach, A. L.; Keller, S.; Radler, J.; Natile, G.; Parak, W. J. Nano Lett. 2004, 4, 703.  

    46. [46]

      (46) Yu, W. W.; Chang, E.; Sayes, C. M.; Drezek, R.; Colvin, V. L. Nanotechnology 2006, 17, 4483.  

    47. [47]

      (47) Li, Z.; Chen, H.; Bao, H. B.; Gao, M. Y. Chem. Mater. 2004, 16, 1391.  

    48. [48]

      (48) Li, Z.; Sun, Q.; Gao, M. Y. Angew. Chem., Int. Edit 2005, 44, 123.  

    49. [49]

      (49) Lu, X. Y.; Niu, M.; Qiao, R. R.; Gao, M. Y. J. Phys. Chem. B 2008, 112, 14390.  

    50. [50]

      (50) Lu, X. Y.; Niu, M.; Yang, C. H.; Yi, L. X.; Qiao, R. R.; Du, M. H.; Gao, M. Y. Chin. Sci. Bull. 2010, 55, 3472.  

    51. [51]

      (51) Li, Z.; Wei, L.; Gao, M. Y.; Lei, H. Adv. Mater. 2005, 17, 1001.  

    52. [52]

      (52) Hu, F. Q.; Li, Z.; Tu, C. F.; Gao, M. Y. J. Colloid Interface Sci. 2007, 311, 469.  

    53. [53]

      (53) Liu, S. J.; Han, Y. C.; Qiao, R. R.; Zeng, J. F.; Jia, Q. J.; Wang, Y. L.; Gao, M. Y. J. Phys. Chem. C 2010, 114, 21270.  

    54. [54]

      (54) Jia, Q.; Zeng, J.; Qiao, R.; Jing, L.; Peng, L.; Gu, F.; Gao, M. J. Am. Chem. Soc. 2011, 133, 19512.  

    55. [55]

      (55) Liu, C. Y.; Jia, Q. J.; Yang, C. H.; Qiao, R. R.; Jing, L. H.; Wang, L. B.; Xu, C. L.; Gao, M. Y. Anal. Chem. 2011, 83, 6778.

    56. [56]

      (56) Williams, D. F. Biomaterials 2008, 29, 2941.  

    57. [57]

      (57) Sun, C.; Lee, J. S. H.; Zhang, M. Q. Adv. Drug Deliv. Rev. 2008, 60, 1252.  

    58. [58]

      (58) Sun, C.; Sze, R.; Zhang, M. Q. J. Biomed. Mater. Res. Part A 2006, 78A, 550.  

    59. [59]

      (59) Yang, L. L.; Mao, H.; Wang, Y. A.; Cao, Z. H.; Peng, X. H.; Wang, X. X.; Duan, H. W.; Ni, C. C.; Yuan, Q. G.; Adams, G.; Smith, M. Q.; Wood, W. C.; Gao, X. H.; Nie, S. M. Small 2009, 5, 235.

    60. [60]

      (60) Lu, J. J.; Wang, F.; Jin, Z. Y.; Zhong, D. R. Acta Acad. Med. Sin., 2008, 31, 124. [陆菁菁, 王芳, 金征宇, 钟定荣. 中国医学科学院学报, 2008, 31, 124.]

    61. [61]

      (61) Sun, C.; Veiseh, O.; Gunn, J.; Fang, C.; Hansen, S.; Lee, D.; Sze, R.; Ellenbogen, R. G.; Olson, J.; Zhang, M. Small 2008, 4, 372.  

    62. [62]

      (62) Lee, H. Y.; Li, Z.; Chen, K.; Hsu, A. R.; Xu, C. J.; Xie, J.; Sun, S. H.; Chen, X. Y. J. Nucl. Med. 2008, 49, 1371.  

    63. [63]

      (63) Qiao, R. R.; Liu, K.; Jia, B.; Zeng, J. F.; Ouyang, H.; Wang, F.; Gao, M. Y. J Southeast Univ (Med Sci Edi) 2011, 30, 4. [乔瑞瑞, 刘侃, 贾兵, 曾剑峰, 欧阳汉, 王凡, 高明远. 东南大学学报(医学版) 2011, 30, 4.]

    64. [64]

      (64) Montet, X.; Montet-Abou, K.; Reynolds, F.; Weissleder, R.; Josephson, L. Neoplasia 2006, 8, 214.  

    65. [65]

      (65) Shi, X. Y.; Wang, S. H.; Swanson, S. D.; Ge, S.; Cao, Z. Y.; Van Antwerp, M. E.; Landmark, K. J.; Baker, J. R. Adv. Mater. 2008, 20, 1671.  

    66. [66]

      (66) Cheon, J.; Lee, J. H. Acc. Chem. Res. 2008, 41, 1630.  

    67. [67]

      (67) Hsieh, C. H.; Kuo, J. W.; Lee, Y. J.; Chang, C. W.; Gelovani, J. G.; Liu, R. S. J. Nucl. Med. 2009, 50, 2049.  

    68. [68]

      (68) Lee, S.; Chen, X. Y. Mol. Imaging 2009, 8, 87.

    69. [69]

      (69) Lin, K. M.; Hsu, C. H.; Chang, W. S. W.; Chen, C. T.; Lee, T. W.; Chen, C. T. Mol. Imaging. Biol. 2008, 10, 253.  

    70. [70]

      (70) Bartels, A. L.; Zeebregts, C. J.; Bijl, M.; Tio, R. A.; Slart, R. H. J. A. Ann. Nucl. Med. 2009, 23, 753.  

    71. [71]

      (71) Pop, M.; Sermesant, M.; Lepiller, D.; Truong, M. V.; McVeigh, E. R.; Crystal, E.; Dick, A.; Delingette, H.; Ayache, N.; Wright, G. A. Med. Image. Anal. 2009, 13, 370.  

    72. [72]

      (72) Choi, J.-S. ; Park, J. C.; Nah, H.; Woo, S.; Oh, J.; Kim, K. M.; Cheon, G. J.; Chang, Y.; Yoo, J.; Cheon, J. Angew. Chem., Int. Ed. 2008, 47, 6259.  

    73. [73]

      (73) Glaus, C.; Rossin, R.; Welch, M. J.; Bao, G. Bioconjugate Chem. 2010, 21, 715.  

    74. [74]

      (74) Yezhelyev, M. V.; Qi, L. F.; O'Regan, R. M.; Nie, S.; Gao, X. H. J. Am. Chem. Soc. 2008, 130, 9006.  

    75. [75]

      (75) Qi, L. F.; Gao, X. H. Acs Nano 2008, 2, 1403.  

    76. [76]

      (76) Veiseh, O.; Sun, C.; Fang, C.; Bhattarai, N.; Gunn, J.; Kievit, F.; Du, K.; Pullar, B.; Lee, D.; Ellenbogen, R. G.; Olson, J.; Zhang, M. Q. Cancer Res. 2009, 69, 6200.  

    77. [77]

      (77) Yang, L.; Mao, H.; Cao, Z. H.; Wang, Y. A.; Peng, X. H.; Wang, X. X.; Sajja, H. K.; Wang, L. Y.; Duan, H. W.; Ni, C. C.; Staley, C. A.; Wood, W. C.; Gao, X. H.; Nie, S. M. Gastroenterology 2009, 136, 1514.  

    78. [78]

      (78) Chen, K.; Xie, J.; Xu, H. Y.; Behera, D.; Michalski, M. H.; Biswal, S.; Wang, A.; Chen, X. Y. Biomaterials 2009, 30, 6912.  

    79. [79]

      (79) Xie, J.; Chen, K.; Huang, J.; Lee, S.; Wang, J. H.; Gao, J.; Li, X. G.; Chen, X. Y. Biomaterials 2010, 31, 3016.  

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