Citation: WAN Dong-Hua, ZHENG Ou, ZHOU Yan, WU Li-Yu. Solubilization of Ibuprofen in Pluronic Block Copolymer F127 Micelles[J]. Acta Physico-Chimica Sinica, ;2010, 26(12): 3243-3248. doi: 10.3866/PKU.WHXB20101207 shu

Solubilization of Ibuprofen in Pluronic Block Copolymer F127 Micelles

1.
College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou 350108, P. R. China

Received Date: 29 April 2010
Available Online: 28 October 2010
Fund Project: 福州大学科技发展基金(2009-XY-07)资助项目 (2009-XY-07)

We studied the effect of Pluronic F127 micelle solution on the solubility of ibuprofen (IBU). The critical micelle concentration (cmc) of F127 in both water and 0.01 mol·L^-1 pH 7.4 phosphate buffer salt (PBS) solution at different temperatures was determined by the pyrene fluorescence method. The concentration of the solubilized IBU was determined using high-performance liquid chromatography (HPLC). We calculated the solubility descriptors (molar solubilization capacity, χ, and micelle-water partition coefficient, K). The influences of temperature, medium properties, and additional copolymer F68 on the micellization of F127 and the solubilization of IBU were also investigated. The results showed that the solubility of IBU increased linearly with an increase in the F127 mass fraction. With an increase in temperature, a significant decrease in the cmc was apparent and a less polar microenvironment was present in the micelle core. Slight increases in χ and K were found with an increase in temperature. The cmc of F127 in PBS solution was much less than that in water, χ was essentially the same and K decreased significantly in PBS solution. F127 micelle property and the solubilization capacity of the F127 micelles were only slightly affected in the presence of F68. An analysis of the solubility descriptors indicates that the K is particularly unique for the drug IBU, and the χ is useful in determining the solubility effectiveness of copolymer F127. We also demonstrated that IBU was predominantly in the micelle core and core-corona interface.
- Pluronic block copolymer,
- Solubilization,
- F127,
- Ibuprofen,
- Micelle
1. [1]
  
  1. Rangel-Yagui, C.O.; Pessoa-Jr, A.; Tavares, L.C. J. Pharm. Pharmaceut. Sci., 2005, 8: 147
2. [2]
  2. Chiappetta, D.A.; Sosnik, A. Eur. J. Pharm. Biopharm., 2007, 66: 303
3. [3]
  3. Hurter, P.N.; Hatton, T.A. Langmuir, 1992, 8: 1291
4. [4]
  4. Gadelle, F.; Koros.W. J.; Schechter, R. S. Macromolecules, 1995, 28: 4883
5. [5]
  5. Dai, L.R.; Chen, J. Acta Phys. -Chim. Sin., 1990, 6: 146
6. [6]
  [戴乐蓉, 陈佳. 物理化学学报, 1990, 6: 146]
7. [7]
  6. Zheng, Y. Y.; Jiang, L. Q.; Zhao, J. X.; Xu, X. Z. Chem. J. Chin. Univ., 2001, 22: 617
8. [8]
  [郑玉婴, 江琳沁, 赵剑曦, 许秀枝. 高等学校化学学报, 2001, 22: 617]
9. [9]
  7. Suh, H.; Jun, H.W. Int. J. Pharm., 1996, 129: 13
10. [10]
  8. Sharma, P. K.; Bhatia, S. R. Int. J. Pharm., 2004, 278: 361
11. [11]
  9. Cafaggi, S.; Russo, E.; Caviglioli, G.; Parodi, B.; Stefani, R.; Sillo, G.; Leardi, R.; Bignardi, G. Eur. J. Pharm. Sci., 2008, 35: 19
12. [12]
  10. Pan,W. S. Industrial pharmacy. Beijing: Higher Education Press, 2006: 144, 186
13. [13]
  [潘卫三. 工业药剂学. 北京: 高等教育出版社, 2006: 144, 186]
14. [14]
  11. Ruel-Gariepy, E.; Leroux, J. C. Eur. J. Pharm. Biopharm., 2004, 58: 409
15. [15]
  12. Zhang, L.; Li, T.; Chen, L.; Li, L.; Qi, G. Chin. J. New Drug, 2006, 15: 952
16. [16]
  [张莉, 李挺, 陈莉, 李丽, 齐刚. 中国新药杂志, 2006, 15: 952]
17. [17]
  13. Rangel-Yagui, C. O.; Hsu, H.W. L.; Pessoa-Jr, A.; Tavares, L. C. RBCF-Braz. J. Pharm. Sci., 2005, 41: 237
18. [18]
  14. Zhang, C. X.; Zhang, J. L.; Li,W.; Feng, X. Y.; Hou, M.Q.; Han, B. X. J. Colloid Interface Sci., 2008, 327: 157
19. [19]
  15. Bakshi, M. S.; Sachar, S. J. Colloid Interface Sci., 2006, 296: 309
20. [20]
  16. Nivaggilioli, T.; Alexandridis, P.; Hatton, T. A.; Yekta, A.;Winnik, M, A. Langmuir, 1995, 11: 730
21. [21]
  17. Zhao, J. X.; Zheng, O.; Lin, C. Y. J. Functional Polym., 2000, 13: 177
22. [22]
  [赵剑曦, 郑欧, 林翠英. 功能高分子学报, 2000, 13: 177]
23. [23]
  18. Pandit, N.; Trygstad, T.; Croy, S.; Bohorquez, M.; Koch, C. J. Colloid Interface Sci., 2000, 222: 213
24. [24]
  19. Gaisford, S.; Beezer, A. E.; Mitchell, J.C. Langmuir, 1997, 13: 2606
25. [25]
  20. Wanka, G.; Hoffmann, H.; Ulbricht,W. Macromolecules, 1994, 27: 4145
26. [26]
  21. Paterson, I. F.; Chowdhry, B. Z.; Leharne, S. A. Langmuir, 1999, 15: 6187
27. [27]
  22. Gadelle, F.; Koros,W. J.; Schechter, R. S. J. Colloid Interface Sci., 1995, 170: 57
28. [28]
  23. Choucair, A.; Eisenberg, A. J. Am. Chem. Soc., 2003, 125: 11993
29. [29]
  24. Crothers, M.; Ricardo, N. M. P. S.; Heatley, F.; Nixon, S. K.; Attwood, D.; Booth, C. Int. J. Pharm., 2008, 358: 303
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