Citation: QIAO Hui, LI Xiao-Qin, XU Hai-Song, KONG Ling-Qiang, PENG Yu. Specificity of Cation-π Interactions in Typical Protein Folds[J]. Acta Physico-Chimica Sinica, ;2010, 26(10): 2828-2832. doi: 10.3866/PKU.WHXB20100939 shu

Specificity of Cation-π Interactions in Typical Protein Folds

1.
School of Life Science and Bioengineering, Beijing University of Technology, Beijing 100124, P. R. China

Received Date: 29 April 2010
Available Online: 27 September 2010
Fund Project: 国家自然科学基金(30570427) 和北京市自然科学基金(4092008) 资助项目 (30570427) 和北京市自然科学基金(4092008)

In proteins, cation-π interactions are formed between positively charged amino acids (Lys, Arg) and aromatic amino acids(Phe, Tyr, Trp). We investigated the cation-π interactions in two typical folding structures of α/β proteins, namely, the singly wound structure and the doubly wound structure. The results reveal that: (1) The distribution density of cation-π interactions in singly wound structures is about 2.6 times as high as that in doubly wound structures; (2) In singly wound structures, a correlation is observed between the amount of residues and their cation-π interactions while no correlation is observed in doubly wound structures; (3) Lys, Arg and Tyr in singly wound structures participate more easily in cation-π interactions than those in doubly wound structures; (4) Arg-Phe pairs are preferred in doubly wound structures while Arg-Tyr pairs are preferred in singly wound structures; (5) In singly wound structures, 65%of the cation-π interactions formarrays or distribute between the starting point and the end point in the structures.
- Singly wound,
- Doubly wound,
- Cation-π interaction,
- Specificity
1. [1]
  
  1. Ma, J. C.; Dougherty, D. A. Chem. Rev., 1997, 97(5): 1303
2. [2]
  2. Mecozzi, S.;West, A. P.; Dougherty, D. A. J. Am. Chem. Soc, 1996, 118(9): 2307
3. [3]
  3. Mecozzi, S.; West, A. P.; Dougherty, D. A. Proc. Natl. Acad. Sci. U. S. A., 1996, 93(20): 10566
4. [4]
  4. Sunner, J.; Nishizawa, K.; Kebarle, P. J. Phys. Chem., 1981, 85 (13): 1814
5. [5]
  5. Gallivan, J. P.; Dougherty, D. A. Proc. Natl. Acad. Sci. U. S. A., 1999, 96(17): 9459
6. [6]
  6. Cheng, J. G.; Luo, X. M.; Yan, X. H.; Li, Z.; Tang, Y.; Jiang, H. L.; Zhu,W. L. Sci. China Ser. B-Chem., 2008, 51(8): 709
7. [7]
  7. Sussman, J. L.; Harel, M.; Frolow, F.; Oefner, C.; ldman, A.; Toker, L.; Silman, I. Science, 1991, 253(5022): 872
8. [8]
  8. Xiu, X.; Puskar, N. L.; Shanata, J. A. P.; Lester, H. A.; Dougherty, D. A. Nature, 2009, 458(7237): 534
9. [9]
  9. Dougherty, D. A. Science, 1996, 271(5246): 163
10. [10]
  10. Prajapati, R. S.; Sirajuddin, M.; Durani, V.; Sreeramulu, S.; Varadarajan, R. Biochemistry, 2006, 45(50): 15000
11. [11]
  11. Gromiha, M. M. Biophysical Chemistry, 2003, 103(3): 251
12. [12]
  12. Crowley, P. B.; lovin, A. Protein, 2005, 59(2): 231
13. [13]
  13. DeVos, A. M.; Ultsch, M.; Kossiakoff, A. A. Science, 1992, 255 (5042): 306
14. [14]
  14. Pflugrath, J. W.; Wigand, G.; Huber, R.; Vertesy, L. J. Mol. Biol., 1986, 189(2): 383
15. [15]
  15. Gromiha, M. M.; Santhosh, C.; Ahmad, S. International Journal of Biological Macromolecules, 2004, 34(3): 203
16. [16]
  16. Gromiha, M. M. Polymer, 2005, 46(3): 983
17. [17]
  17. Anbarasu, A.; Anand, S.; Mathew, L.; Sethumadhavan, R. International Journal of Biological Macromolecules, 2007, 40(5): 479
18. [18]
  18. Chakkaravarthi, S.; Gromiha, M. M. Polymer, 2006, 47(2): 709
19. [19]
  19. Shanthi, V.; Ramanathan, K.; Sethumadhavan, R. Journal of Computer Science&Systems Biology, 2009, 2(1): 51
20. [20]
  20. Prasad, V. R.; Sathpathy, S. Protoplasma, 2009, 238(1-4): 11
21. [21]
  21. Wintjens, R.; Liévin, J.; Rooman, M.; Buisine, E. J. Mol. Biol., 2000, 302(2): 395
22. [22]
  22. http://astral.berkeley.edu/scopseq-1.65.html
23. [23]
  23. http://capture.caltech.edu/
24. [24]
  24. Jorgensen,W. L.; Tirado-Rives, J. J. Am. Chem. Soc., 1988, 110 (6): 1657
25. [25]
  25. Jorgensen,W. L.; Maxwell, D. S.; Tirado-Rives, J. J. Am. Chem. Soc., 1996, 118(45): 11225
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沈阳化工大学材料科学与工程学院沈阳 110142