Citation: HE Xiao-Dan, JIANG Dan, CHEN Chen, CHU Yan-Qiu, DING Chuan-Fan, WENG Zhi-Jie, LI Jian-Qi. Non-Covalent Complexes of the Antidepressant Compound SIPI5358 with Cyclodextrins[J]. Acta Physico-Chimica Sinica, ;2010, 26(10): 2604-2612. doi: 10.3866/PKU.WHXB20100911 shu

Non-Covalent Complexes of the Antidepressant Compound SIPI5358 with Cyclodextrins

1.
1. Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Institute of Laser Chemistry, Department of Chemistry, Fudan University, Shanghai 200433, P. R. China;
2. Shanghai Institute of Pharmaceutical Industry, Shanghai 200040, P. R. China

Received Date: 5 March 2010
Available Online: 27 September 2010
Fund Project: 国家自然科学基金(30772623) (30772623)国家十一五项目重大新药创制(2009ZX09103-047)资助项目 (2009ZX09103-047)

Non-covalent complexes of α-, β-, and γ-cyclodextrin (CD) with the antidepressant compound SIPI5358 were investigated by electrospray ionization mass spectrometry (ESI-MS), tandem mass spectrometry (MS/MS), UV spectroscopy, and fluorescence spectroscopy. The ESI-MS experimental results revealed that SIPI5358 reacted with the α-, β-, and γ-CD to form complexes with different coordination numbers. The tandem mass spectra further confirmed the formation of non-covalent complexes of SIPI5358 with β-CD. Binding of the complexes was also confirmed by UV as well as fluorescence spectra. The formation constant K_f was determined by fluorescence spectroscopy to be 3.45 ×10³mol·L^-1for the complex of SIPI5358 and β-CD.
- Cyclodextrin,
- Antidepressant,
- Non-covalent complex,
- UV spectroscopy,
- Electrospray ionization mass spectrometry,
- Fluorescence spectroscopy
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