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Citation: XU Yuan-Chao, YANG Yi, DU Li-Bo, SHEN Jian-Gang, WANG Guang-Qing, HE Zeng, TIAN Qiu, LIU Yang. Autoxidation and Prooxidation Mechanisms of Danshensu[J]. Acta Physico-Chimica Sinica, ;2010, 26(07): 1737-1741. doi: 10.3866/PKU.WHXB20100710 shu

Autoxidation and Prooxidation Mechanisms of Danshensu

1.
School of Science, Beijing University of Chemical Technology, Beijing 100029, P. R. China
Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China
School of Chinese Medicine, The University of Hong Kong, Hong Kong, P. R. China

Received Date: 30 January 2010
Available Online: 19 May 2010

A hydrogen peroxide (H2O2) electrode and electron spin resonance (ESR) methods were used to continuously monitor and analyze the autoxidation and prooxidation of Danshensu in aqueous solutions with various pH values. We found that Danshensu exhibited obvious autoxidative activity in alkalescence buffer solutions (pH=8.5) and the presence of Cu2+ evidently accelerated the generation of H2O2. The primary product of the autoxidation was a superoxide anion radical (O2-·) and then it could be converted into H2O2. The autoxidation of Danshensu was totally inhibited under weak acidic conditions (pH=6.5) and a partial prooxidation of Danshensu occurred in the presence of cupric ion. However, under physiological conditions (pH=7.4), the autoxidation of Danshensu was very slow and its prooxidation, initiated by Cu2+, was very limited. Consequently, the autoxidation and prooxidation of Danshensu cannot be completely ignored when used in clinical practice especially under alkaline body fluid conditions.
- Danshensu,
- Hydrogen peroxide electrode,
- Autoxidation,
- Prooxidation,
- Superoxide anion
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