Citation: HUANG Yong-Qi, LIU Zhi-Rong. Intrinsically Disordered Proteins: the New[J]. Acta Physico-Chimica Sinica, ;2010, 26(08): 2061-2072. doi: 10.3866/PKU.WHXB20100644 shu

Intrinsically Disordered Proteins: the New

1.
Beijing National Laboratory for Molecular Sciences, Center for Theoretical Biology, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, P. R. China

Received Date: 3 February 2010
Available Online: 13 May 2010
Fund Project: 国家自然科学基金(20973016、10721403) (20973016、10721403)国家重点基础研究发展计划项目(973) (2009CB918500) (973) (2009CB918500)

Intrinsically disordered proteins (IDPs) are a new class of proteins which lack a unique tertiary structure under native conditions while possessing essential biological functions. They take part in various physiological processes such as signal transduction, transcription and translation regulation, and protein modification. The discovery of IDPs challenges the conventional protein “sequence-structure-function” paradigm. In this review, we first overview the history of the conventional protein paradigm and the discovery of IDPs. Then we discuss the characteristics of IDPs in terms of sequence, structure, and biological function. Taking molecular recognition processes as an example, we further introduce current opinions on the advantages of IDPs in binding. Finally, we analyze possible applications of the study of IDPs such as further understanding the protein folding mechanism, improving protein structure determination, providing new clues for protein design and new targets for drug design. The current status of IDPs study in China is also briefly presented.
- Intrinsically disordered protein,
- Protein folding,
- Protein interaction,
- Molecular recognition,
- ,
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