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Citation: BAO Hong-Juan, ZHANG Yan-Ling, QIAO Yan-Jiang. Pharmacophore Model Generation of HMG-CoA Reductase Inhibitors[J]. Acta Physico-Chimica Sinica, ;2008, 24(02): 301-306. doi: 10.3866/PKU.WHXB20080220 shu

Pharmacophore Model Generation of HMG-CoA Reductase Inhibitors

1.
School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, P. R. China

Received Date: 19 July 2007
Available Online: 2 January 2008

A three-dimensional pharmacophore model of 3-hydro-3-methyl glutaryl coenzyme A (HMG-CoA) reductase inhibitors (RI)was developed based on 21 HMG-CoAreductase inhibitors froma rat liver. The selected training set had great diversity in both molecular structure and bioactivity as required by HypoGen program in the Catalyst software. The inhibitors in training set showed HMG-CoA RI inhibiting activity with IC50 values of 0.3-8000 nmol·L-1. The best statistical hypothesis, consisting of four features, one hydrogen-bond acceptor, one hydrogen-bond donor, one ring aromatic feature, and one hydrophobic point, had a correlation coefficient of 0.8883, a root-mean-square (RMS) deviation of 1.269, a Fixed cost of 88.75, a Total cost of 111.5, and a Configuration cost of 16.98, this hypothesis had highly predictive ability. The predictive ability was approved by the results of the activity estimated by mapping the compounds of the testing set with it. The cross-validation provided strong confidence on this hypothesis. This pharmacophore model can contribute to the finding and designing of new-type HMG-CoA reductase inhibitors, and to the development of traditional Chinese medicine and materia medica.
- HMG-CoA reductase inhibitor; Pharmacophore; Database searching
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1.
沈阳化工大学材料科学与工程学院沈阳 110142

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Pharmacophore Model Generation of HMG-CoA Reductase Inhibitors

南开大学师唯/华北电力大学（保定）刘景维：二维配位聚合物中有序的亲锂冠醚位点用于无枝晶锂沉积

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通讯作者: 陈斌, bchen63@163.com