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Citation: YAN Bin, AN Xue-qin, BAI Jing, ZHANG Ying-hua. Preparation of Cefazolin Sodium Liposomes by Supercritical Carbon Dioxide Method[J]. Acta Physico-Chimica Sinica, ;2006, 22(02): 226-229. doi: 10.3866/PKU.WHXB20060219 shu

Preparation of Cefazolin Sodium Liposomes by Supercritical Carbon Dioxide Method

1.
College of Chemistry and Environment Science, Nanjing Normal University, Nanjing 210097, P. R. China

Received Date: 18 July 2005
Available Online: 22 January 2006

The liposomes of cefazolin sodium were prepared using one step supercritical CO2 (scCO2) method. The size, stability, and trapping efficiency of liposomes were investigated. The experimental results demonstrate that the size and stability of liposomes depend on the pressure. The trapping efficiency of liposomes relates to the concentration of ethanol and lipid. The trapping efficiency by the scCO2 method is much higher than the results from the Bangham method.
- Liposomes;Cefazolin sodium;scCO2;Trapping efficiency;Particle size;Stability
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