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Citation: Guo Ming, Yan Jian-Wei, Yu Qing-Sen, Shang Zhi-Cai, Lü Jian-De. Characterization of Interaction between Gatifloxacin and Bovine Serum Albumin[J]. Acta Physico-Chimica Sinica, ;2004, 20(02): 202-206. doi: 10.3866/PKU.WHXB20040220 shu

Characterization of Interaction between Gatifloxacin and Bovine Serum Albumin

1.
Department of Chemistry, Department of Chinese Medicine Science ＆ Engineering, Zhejiang University, Hangzhou　310027

Received Date: 21 June 2003
Available Online: 15 February 2004

The present study describes the application of capillary zone electrophoresis(CZE) to investigate the interaction between bovine serum albumin and gatifloxacin, the simplified method of Hummel-Dreyer was applied and the experimental condition was established after a large number of tests. Based on the site-binding model, practical formula for small ligand molecule to bio-macromolecule has been proposed; the binding parameters were measured according to suggested model by non-linear fitting program.
- Gatifloxacin;Bovine serum albumin(BSA);Capillary electrophoresis;　Non-linear fitting
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