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Citation: Shen Xue-Song, Liu Yi, Hou An-Xin, Zhao Ru-Ming, Qu Song-Sheng. Thermochemical Studies of the Synergism of Pr^3＋or La^3＋ and Clarithromycin on Escherichia coli Growth Metabolism[J]. Acta Physico-Chimica Sinica, ;2003, 19(06): 560-563. doi: 10.3866/PKU.WHXB20030617 shu

Thermochemical Studies of the Synergism of Pr^3＋or La^3＋ and Clarithromycin on Escherichia coli Growth Metabolism

1.
College of Chemistry and Molecular Sciences,Wuhan University,Wuhan　430072;Guilin Medical College,Guilin　541001

Received Date: 22 October 2002
Available Online: 15 June 2003

Using 2277 bioactivity monitoring system,we determined the changes of heat effect of inhibition of Clarithromycin with Pr(NO3)3 or La(NO3)3 on Escherichia coli growth at 37 ℃.According to the thermokinetic model,the relationship between the concentration of antibiotics (c) and growth rate constant (k) and its half inhibitory concentration,Ic50,were analyzed quantitatively. Clarithromycin: k=0.03106－1.273×10－3c　Ic50=8.81 μg•mL－1　(0.5～20 μg•mL－1) Clarithromycin＋Pr3＋: k=0.02967－1.332×10－3c　Ic50=7.38 μg•mL－1　(1～15 μg•mL－1) Clarithromycin＋La3＋: k=0.02741－1.194×10－3c　Ic50=6.34 μg•mL－1 (1～15 μg•mL－1) 　　The results of microcalorimetry experiments not only indicated that antibacterial activity of Clarithromycin was stronger than that of erythromycin,but also the changeable features of thermokinetics of the bacterial cell in biological,biochemical and metabolic process under the action of different drugs.
- Pr^3＋;La^3＋;Clarithromycin;Erythromycin;　Escherichia coli;Thermochemistry
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Thermochemical Studies of the Synergism of Pr3＋or La3＋ and Clarithromycin on Escherichia coli Growth Metabolism

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Thermochemical Studies of the Synergism of Pr^3＋or La^3＋ and Clarithromycin on Escherichia coli Growth Metabolism