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Citation: Xu Si-Chuan, Zhang Hui-Juan, Sun Zhao-Yong, Feng Juan, Ai Xi-Cheng, Zhang Qi-Yuan, Zhang Xing-Kang, Liu Yan-Qin, Han Shi-Tian. Synthesis and Spectroscopy Characteristics of 5-fluorouracil Porphyrin Compounds[J]. Acta Physico-Chimica Sinica, ;2001, 17(10): 879-886. doi: 10.3866/PKU.WHXB20011004 shu

Synthesis and Spectroscopy Characteristics of 5-fluorouracil Porphyrin Compounds

1.
State Key Laboratory for Structural Chemistry of Unstable and Stable Species, Molecular Science Center, Institute of Chemistry, Chinese Academy of Sciences, Beijing　100080;Department of Chemistry, Hebei Normal University, Shijiazhuang　050091

Received Date: 16 April 2001
Available Online: 15 October 2001

5fluorouracil porphyrin compounds are a new type of potential antitumor drugs. Six new 5fluorouracil porphyrin compounds were synthesized first and characterized by means of elemental analysis, IR, 1HNMR and MS. The six 5fluorouracil porphyrin compounds were studied by absorption spectra, steadystate fluorescence spectroscopy and timeresolved single photon measurement, comparing with their primary porphyrin compounds. The 5fluorouracil porphyrin compounds with plentiful excited states and fluorescence lifetime of 7 ns are little influenced by substituents and solvents, which may be advantageously used to make singlet oxygen radical.
- 5-fluorouracil;Porphyrin;Fluorescence lifetime;Single photon measurement
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