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Citation: Huan Yu, Chu De-Ying, Tang Yong, Cao Wei. Microcalorimetry Study on the Reaction of Metallothionein with Cd²⁺ and Pb²⁺[J]. Acta Physico-Chimica Sinica, ;2000, 16(08): 764-768. doi: 10.3866/PKU.WHXB20000818 shu

Microcalorimetry Study on the Reaction of Metallothionein with Cd²⁺ and Pb²⁺

1.
College of Chemistry and Molecular Engineering,Peking University,Beijing 100871

Received Date: 17 December 1999
Available Online: 15 August 2000

Metallothionein, a class of low molecular weight, metal- and cysteine-rich Proteins, are postulated to play a central role in metal-related biological processes such as the detoxification of Cd2+and Pb2+. The thermal Properties of the interactions of rabbit liver Zn_7MT2 and apo-MT2 with Cd2+ and Pb2+ were studied using isothermal titration calorimeter. The same product Cd_7MT formed in the reactions of Cd2+ with Zn_7MT2 and apo-MT2, while the reactions of Ph2+ with Zn_7MT2 and apo-MT2 Produced two MT species Ph_7MT and Ph_7MT'. The thermodynamic parameters (△H、 △G、 △S, etc. ) for the reactions of MT with 1 mol metal ions were measured at 293.15 K, pH 4.70. All of these reactions are spontaneous, exothermic processes. The values of △G and K show that Cd2+ is more affinitive to MT than Ph2+. The equilibrium constants K of the replacement reactions of Zn_7MT2 by 1 mol Cd2+ and Pb2+ are 2. 7×105 and 1. 3×105 respectively, that means the concentrations of free Cd2+ and Pb2+ are depressed to about 1. 0×10-5 after the reactions with Zn_7MT2. These data can be used to evaluate quantitatively the ability of MT in Cd2+ and Pb2+ detoxificatio.
- Metallothionein,
- Cadmium(II) ion,
- Lead(II) ion,
- Isothermal titration calorimetry
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Microcalorimetry Study on the Reaction of Metallothionein with Cd2+ and Pb2+

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通讯作者: 陈斌, bchen63@163.com

Microcalorimetry Study on the Reaction of Metallothionein with Cd²⁺ and Pb²⁺