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Citation: Yang Yong, Wang Bao-Huai, Li Zhi-Fen, Zhang You-Min, Han ng-She, Yan Long-Fei. The Polymerization and Denaturation of Brain Tubulin and the Effect of Taxol by Differential Scanning Calorimetry[J]. Acta Physico-Chimica Sinica, ;1999, 15(02): 182-185. doi: 10.3866/PKU.WHXB19990217 shu

The Polymerization and Denaturation of Brain Tubulin and the Effect of Taxol by Differential Scanning Calorimetry

1.
Institute of Physical Chemistry,Peking University,Beijing 100871

Received Date: 2 March 1998
Available Online: 15 February 1999

The thermal properties of porcine brain tubulin polymerization and denaturation and the effects of taxol were studied from 4 ℃ to 115 ℃ with a new highly-sensitive differential scanning calorimeter (Micro DSC Ⅲ, Setaram, France). The DSC results indicated that microtubule polymerization can proceed uia an endothermic process and that taxol could alter the process. A large aggregation peak was found at about 85 ℃ in the course of the denaturation and it disappeared with adding taxol. The heat flow oscillation was observed during the controlled-temperature experiments and taxol could stabilize the structure of the microtubules so that the oscillation disappeared.
- Tubulin,
- Taxol,
- DSC,
- Polymerization,
- Denaturation,
- Thermal oscillation
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