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Citation: Tan An-Min, Xu Bo, Qu Song-Sheng. Microcalorimetric Study on Induced Differentiation of Tumour Cells by Drug[J]. Acta Physico-Chimica Sinica, ;1996, 12(09): 849-851. doi: 10.3866/PKU.WHXB19960915 shu

Microcalorimetric Study on Induced Differentiation of Tumour Cells by Drug

1.
Department of Chemsitry,Wuhan University,Wuhan 430072

Received Date: 29 January 1996
Available Online: 15 September 1996

Sp-Octyl-(8-Chloroadenosine)-3',5'-Cyclophosphate (OCC), a newlysynthesized cAMP analog, strongly induces growth inhibition and differentiation in human promyelocytic leukemia HL-60 cells. The effect of OCC is dose-time dependent. By using the LKB2277 Bioactivity Monitor, we determined the heat production rate of HL-60 cells treated by OCC at different concentrations. It was found that the heat production rate of HL-60 cell treated by OCC gradually decreased to that of normal human neutrophiles.
- Microcalorimetry,
- OCC;HL-60 cells,
- Induced differentiation
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