Abstract: The cultivation of outstanding innovative talents in fundamental disciplines is a crucial task for universities in talent development. The chemistry program at Peking University (PKU) is committed to educating future leaders in the field of chemistry and related areas who are patriotic, science-oriented, and possess a keen sense of social responsibility, exceptional scientific and cultural literacy, as well as integrity, independent critical thinking skills, and international competitiveness. Through years of practical exploration and development, PKU graduate student cultivation in the chemistry program has been steadily forging a path with well-defined objectives, distinct characteristics, a comprehensive system of rules and regulations, and remarkable results. Simultaneously, as international competition in science, technology and talent intensifies, new urgent demands are being placed on talent cultivation in domestic chemistry discipline. To address these new challenges, Peking university’s chemistry program is also continuously exploring new initiatives, such as classified talent training, integrated bachelor-doctoral training tracks, and high-level innovative talent development initiatives.