Abstract: Coordination chemistry, fundamental to understanding molecular interactions, has played a pivotal role in various fields from ancient dyeing techniques to modern industrial applications. However, public awareness of coordination chemistry remains limited. This interdisciplinary experiment integrates traditional mordant dyeing techniques with coordination chemistry to elucidate the rich colors and complexities behind dyeing processes. Utilizing plant pigments like alizarin and hematoxylin, the experiment showcases the formation of complex compounds through metal ion coordination, emphasizing the pivotal role of coordination chemistry in dyeing and fixation effects. Inspired by China’s intangible cultural heritage, tie-dyeing, the experiment further demonstrates the fusion of chemistry, art, and culture through the creation of tie-dye works, showcasing both the beauty of chemistry and the craftsmanship of traditional Chinese handicrafts. Additionally, a home experiment plan utilizing onion skin to produce dyes promotes hands-on experimentation and highlights the experiment’s accessibility and applicability to diverse audiences. This comprehensive science popularization initiative caters to young children, students at different educational levels, and the general public, promoting a deeper understanding of chemistry while emphasizing sustainability and safety.