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Citation: Junjie Zhang, Yue Wang, Qiuhan Wu, Ruquan Shen, Han Liu, Xinhua Duan. Preparation and Selective Separation of Lightweight Magnetic Molecularly Imprinted Polymers for Trace Tetracycline Detection in Milk[J]. University Chemistry, ;2024, 39(5): 251-257. doi: 10.3866/PKU.DXHX202311084 shu

Preparation and Selective Separation of Lightweight Magnetic Molecularly Imprinted Polymers for Trace Tetracycline Detection in Milk

School of Chemistry, Xi’an Jiaotong University, Xi’an 710049, China

Received Date: 29 November 2023
Revised Date: 4 February 2024

This experiment addresses the pressing issue of milk safety, integrating cutting-edge molecular imprinting technology into undergraduate laboratory classes. A comprehensive experiment is designed, combining molecular imprinting, protein exclusion, and magnetic separation techniques to synthesize lightweight magnetic molecularly imprinted polymers. The polymers’ performance is evaluated, and they are utilized as solid-phase extraction adsorbents in conjunction with high-performance liquid chromatography to establish a novel method for the direct and selective detection of trace tetracycline in milk samples. This interdisciplinary study spans materials chemistry, analytical chemistry, instrumental chemistry, and food chemistry, fostering students’ scientific literacy, problem-solving abilities, and innovative thinking. The innovative design of the imprinting material and magnetic separation process ensures cost-effectiveness, ease of operation, and high safety throughout the experiment. Through this hands-on experience, students gain insight into molecular imprinting technology, learn new detection methods, refine basic laboratory skills, enhance data collection and analysis capabilities, and deepen their understanding of the interplay between components, performance, and application.
- Molecularly imprinted polymer,
- Milk,
- Tetracycline,
- Comprehensive chemistry experiment
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