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Citation: Yuting Zhang, Zhiqian Wang. Methods and Case Studies for In-Depth Learning of the Aldol Reaction Based on Its Reversible Nature[J]. University Chemistry, ;2024, 39(7): 377-380. doi: 10.3866/PKU.DXHX202311037 shu

Methods and Case Studies for In-Depth Learning of the Aldol Reaction Based on Its Reversible Nature

College of Chemistry, Beijing University of Chemical Technology, Beijing 100029, China

Received Date: 12 November 2023
Revised Date: 8 January 2024

The Aldol reaction is a key and challenging topic in the foundational organic chemistry course. In our teaching practice, we have found that explaining the principles of the Aldol reaction based on its reversibility and providing mechanism problems can effectively deepen students’ understanding and awareness of the Aldol reaction, thus enhancing the teaching effectiveness. In this article, we share three typical examples of rearrangement reactions based on reversible Aldol reactions, which can serve as references for teachers and students in their teaching and learning endeavors.
- Aldol reaction,
- Reversibility,
- Rearrangement
1. [1]
2. [2]
  Matsuo, J.-I.; Murakami, M. Angew. Chem. Int. Ed. 2013, 52(35), 9109.
3. [3]
4. [4]
5. [5]
  McCurry, P. M., Jr.; Singh, R. K. J. Org. Chem. 1974, 39 (15), 2317.
6. [6]
  Jung, M. E.; Murakami, M. Org. Lett. 2006, 8(25), 5857.
7. [7]
  Yang, W.; Digits, C. A.; Hatada, M.; Narula, S.; Rozamus, L. W.; Huestis, C. M.; Wong, J.; Dalgarno, D.; Holt, D. A. Org. Lett. 1999, 1(12), 2033.
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