固氮酶活性中心研究五十年

引用本文: 陈全亮, 周朝晖. 固氮酶活性中心研究五十年[J]. 大学化学, 2024, 39(7): 287-293. doi: 10.3866/PKU.DXHX202310133 shu

Citation: Quanliang Chen, Zhaohui Zhou. Research on the Active Site of Nitrogenase over Fifty Years[J]. University Chemistry, 2024, 39(7): 287-293. doi: 10.3866/PKU.DXHX202310133 shu

固氮酶活性中心研究五十年

陈全亮 ^1, ,
周朝晖 ^2,

1.
西南民族大学化学与环境学院, 成都 610041;
2.
厦门大学化学化工学院, 固体表面物理化学国家重点实验室, 福建厦门 361005
基金项目:
国家自然科学基金(22179110)

摘要: 固氮酶是固氮微生物在常温常压下固氮成氨的催化剂，其活性中心的结构从Fe₂S₂∙Mo₂O₂演变到MoFe₇S₉C(R-Hhomocit)(cys)(his) (H₄homocit = 高柠檬酸，Hcys = 半胱氨酸，Hhis = 组氨酸)。本文将回顾这一重要的历史过程，探讨化学模拟、光谱学、理论计算和生物化学，特别是结构生物学等领域在固氮酶活性中心研究中的重要成就，从化学结构的角度看固氮酶活性中心研究五十年。

关键词:

English

Research on the Active Site of Nitrogenase over Fifty Years

Quanliang Chen ^1, ,
Zhaohui Zhou ^2,

1.
College of Chemistry and Environment, Southwest Minzu University, Chengdu 610041, China;
2.
State Key Laboratory of Physical Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, Fujian Province, China
Received Date: 31 October 2023
Revised Date: 01 February 2024
Available Online: 21 February 2024

Abstract: Nitrogenase is a catalyst used by nitrogen-fixing microorganisms to convert atmospheric nitrogen into ammonia at ambient temperature and pressure. The structure of the active site in molybdenum nitrogenase has evolved from Fe₂S₂∙Mo₂O₂ to MoFe₇S₉C(R-Hhomocit)(cys)(his) (H₄homocit = homocitric acid, Hcys = cysteine, Hhis = histidine) through advancements in chemical modeling, spectroscopy, and theoretical calculations, especially for structural biology. This paper provides a comprehensive review of the important achievements in the study of the active site of nitrogenase from a chemical structure perspective over the past fifty years.

Key words:

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1.
沈阳化工大学材料科学与工程学院沈阳 110142

固氮酶活性中心研究五十年

English

Research on the Active Site of Nitrogenase over Fifty Years

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通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

固氮酶活性中心研究五十年

English

Research on the Active Site of Nitrogenase over Fifty Years

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南： 你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

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通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

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