抗击癌症之光——光动力治疗

引用本文: 吕鑫, 张洪星, 段凯博, 戴文惠, 文智慧, 郭炜, 郝俊生. 抗击癌症之光——光动力治疗[J]. 大学化学, 2024, 39(5): 70-79. doi: 10.3866/PKU.DXHX202309090 shu

Citation: Xin Lv, Hongxing Zhang, Kaibo Duan, Wenhui Dai, Zhihui Wen, Wei Guo, Junsheng Hao. Lighting the Way Against Cancer: Photodynamic Therapy[J]. University Chemistry, 2024, 39(5): 70-79. doi: 10.3866/PKU.DXHX202309090 shu

抗击癌症之光——光动力治疗

山西大学化学化工学院, 太原 030006
基金项目:
山西省高等学校教学改革创新项目(J2021097, J2021099)；国家自然科学基金(22277070)

摘要: 光动力治疗是利用“光敏剂”和“光”治疗肿瘤的一种新方法，用特定波长的光照射肿瘤部位，可以使聚集在肿瘤的光敏剂活化，产生高氧化性的活性氧而破坏肿瘤。与手术治疗、化疗、辐射治疗相比，光动力治疗具有操作简单、靶向性好、无创或微创、无耐药性、可激活全身免疫等特点。该治疗方法在发达国家已基本普及，目前在我国正处于推广阶段，公众对光动力治疗还不甚了解，因此急需进行科学普及。在此背景下，我们利用实验室化学合成的靶向型“硒-罗丹明”光敏剂，设计了肿瘤靶向的光动力治疗科普实验，包括靶向光敏剂的酶激活，单线态氧的可视化检测以及光动力杀死癌细胞三个环节。通过该科普实验，生动诠释了靶向型光动力治疗的科学原理，提高了公众对光动力治疗癌症的认知，将大大促进光动力治疗在我国的推广，也体现了化学在肿瘤治疗方面的重要作用。整个科普实验操作简单、形象直观，并在科普实践中显示出良好效果。

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English

Lighting the Way Against Cancer: Photodynamic Therapy

School of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, China
Received Date: 25 September 2023
Revised Date: 17 January 2024

Abstract: Photodynamic therapy (PDT) emerges as a novel approach to treat tumors utilizing “photosensitizers” and “light”. This method involves exposing the tumor site to specific wavelengths of light, activating photosensitizers concentrated in the tumor to generate highly oxidizing reactive oxygen species, ultimately dismantling the tumor. In comparison to surgery, chemotherapy, and radiation therapy, PDT boasts simplicity in operation, precise targeting, minimal invasiveness, lack of drug resistance, and the ability to trigger systemic immunity. While PDT has gained widespread adoption in developed nations, its promotion in China is still underway, hampered by a lack of public understanding. In response, we present a popular science experiment elucidating tumor-targeted photodynamic therapy using a laboratory-synthesized selenium-Rhodamine photosensitizer. The experiment encompasses enzyme activation of targeted photosensitizers, visual detection of singlet oxygen, and the photodynamic eradication of cancer cells. This experiment vividly illustrates the scientific principles behind targeted photodynamic therapy, enhancing public awareness of photodynamic cancer treatment. Such efforts are crucial for advancing the adoption of photodynamic therapy in our country, underscoring the pivotal role of chemistry in cancer treatment. The entire popular science experiment is straightforward, visually intuitive, and has demonstrated effective results in science outreach.

Key words:

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沈阳化工大学材料科学与工程学院沈阳 110142

抗击癌症之光——光动力治疗

English

Lighting the Way Against Cancer: Photodynamic Therapy

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

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通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

抗击癌症之光——光动力治疗

English

Lighting the Way Against Cancer: Photodynamic Therapy

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南： 你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

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通讯作者: 陈斌, bchen63@163.com

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