Abstract: Laboratory common instruments and glassware safety are necessary knowledge and skills for laboratory. In this case, the specialized knowledge is organically combined with ideological and political elements. The laboratory common instruments and glassware safety are related to the safety accidents in the laboratories of university and real life. The multi-integration teaching design and implementation centering on students’ core competencies further strengthen the students’ awareness of safety and environmental protection, stimulate the students’ interest in learning. The corresponding knowledge of adopted online MOOC is extended, expanded and supplemented. These cultivate the students’ knowledge transfer ability, make students fully realize the significance of laboratory instruments and glassware safety for the safe operation of laboratories as well as national security and stability, enhance the students’ social responsibility, and play a good role in improving students’ ability and quality.