Home

Citation: Feng Li, Ranran Meng, Hanzhi Zhang, Yingjuan Qu, Jingwu Kang. Determination of Stereoisomeric Impurities of Glycopyrrolate Bromide by Capillary Electrophoresis: Recommendation of a Pharmaceutical Analysis Experiment[J]. University Chemistry, ;2023, 38(12): 67-74. doi: 10.3866/PKU.DXHX202307023 shu

Determination of Stereoisomeric Impurities of Glycopyrrolate Bromide by Capillary Electrophoresis: Recommendation of a Pharmaceutical Analysis Experiment

Feng Li ^1,, ,
Ranran Meng ² ,
Hanzhi Zhang ³ ,
Yingjuan Qu ¹ ,
Jingwu Kang ^2,,

1.
Xi'an Key Laboratory of Food Safety Testing and Risk Assessment, School of Chemical Engineering, Xi'an University, Xi'an 710065, China;
2.
State Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China;
3.
Abiochem Biotechnology Co., Ltd., Shanghai 200241, China

Corresponding author: Feng Li, Jingwu Kang,
Received Date: 10 July 2023

This article recommends a pharmaceutical analysis experiment “chiral capillary electrophoresis analysis of the stereoisomers of the drug Glycopyrrolate bromide”. The experiment includes the selection of cyclodextrin chiral selector, optimization of capillary electrophoresis separation conditions, and construction of a standard curve. From the perspective of pharmaceutical analysis, this experiment focuses on introducing the principle of capillary electrophoresis analysis, the principle of chiral separation, and the importance of analyzing stereoisomeric impurities in drugs. It is suggested to be offered in majors such as applied chemistry, pharmacy, and pharmaceutical engineering.
- Capillary electrophoresis,
- Chiral analysis,
- Glycopyrrolate bromide,
- Cyclodextrin,
- Pharmaceutical analysis experiment
1. [1]
  Xing, J.; Wang, F.; Cong, H. L.; Wang, S.; Shen, Y. Q.; Yu, B. Analyst 2021,146 (4), 1320.
2. [2]
  Agranat, I.; Caner, I.; Caldwell, J. Nat. Rev. Drug Discov. 2002, 1 (10), 753.
3. [3]
4. [4]
  Mane, S. Anal. Method 2016, 8 (42), 7567.
5. [5]
6. [6]
  Meng, R. R.; Kang, J. W. J. Chromatogr. A 2017, 1506, 120.
7. [7]
8. [8]
  Németh, K.; Tárkányi, G.; Varga, E.; Imre, T.; Mizsei, R.; Iványi, R.; Visy, J.; Szemán, J.; Jicsinszky, L.; Szente, L.; et al. J. Pharm. Biomed. Anal. 2011, 54 (3), 475.
9. [9]
10. [10]
  Suntornsuk, L.; Anurukvorakun, O. Electrophoresis 2022, 43 (9), 939.
11. [11]
  Wren, S. A. C.; Rowe, R. C. J. Chromatogr. A 1992, 603 (1-2), 235.
12. [12]
  Saz, J. M.; Marina, M. L. J. Chromatogr. A 2016, 1467, 79.
13. [13]
14. [14]
  Albertson, T. E.; Chenoweth, J. A.; Adams, J. Y.; Sutter, M. E. Expert Opin. Inv. Drug 2017, 26 (1), 35.
15. [15]
  Yu, H.; Xia, H.; Tang, Q.; Xu, H.; Wei, G.; Chen, Y.; Dai, X.; Gong, Q.; Bi, F. Sci. Rep. 2017, 7, 1.
16. [16]
  Meadowcraft, L.; Mospan, G.; Morrisette, T.; Smart, K.; Janis, M. Nurse Pract. 2016, 41 (12), 20.
1. [1]
  Conghao Shi , Ranran Wang , Juli Jiang , Leyong Wang . The Illustration on Stereoisomers of Macrocycles Containing Multiple Chiral Centers via Tröger Base-based Macrocycles. University Chemistry, 2024, 39(7): 394-397. doi: 10.3866/PKU.DXHX202311034
2. [2]
  Dongheng WANG , Si LI , Shuangquan ZANG . Construction of chiral alkynyl silver chains and modulation of chiral optical properties. Chinese Journal of Inorganic Chemistry, 2025, 41(1): 131-140. doi: 10.11862/CJIC.20240379
3. [3]
  Tingyu Zhu , Hui Zhang , Wenwei Zhang . Exploration and Practice of Ideological and Political Education in the Course of Experiments on Chemical Functional Molecules: Synthesis and Catalytic Performance Study of Chiral Mn(III)Cl-Salen Complex. University Chemistry, 2024, 39(4): 75-80. doi: 10.3866/PKU.DXHX202311011
4. [4]
  Yan Li , Xinze Wang , Xue Yao , Shouyun Yu . 基于激发态手性铜催化的烯烃E→Z异构的动力学拆分——推荐一个本科生综合化学实验. University Chemistry, 2024, 39(5): 1-10. doi: 10.3866/PKU.DXHX202309053
5. [5]
  Jin Tong , Shuyan Yu . Crystal Engineering for Supramolecular Chirality. University Chemistry, 2024, 39(3): 86-93. doi: 10.3866/PKU.DXHX202308113
6. [6]
  Renxiao Liang , Zhe Zhong , Zhangling Jin , Lijuan Shi , Yixia Jia . A Palladium/Chiral Phosphoric Acid Relay Catalysis for the One-Pot Three-Step Synthesis of Chiral Tetrahydroquinoline. University Chemistry, 2024, 39(5): 209-217. doi: 10.3866/PKU.DXHX202311024
7. [7]
  Haiying Wang , Andrew C.-H. Sue . How to Visually Identify Homochiral Crystals. University Chemistry, 2024, 39(3): 78-85. doi: 10.3866/PKU.DXHX202309004
8. [8]
  Keying Qu , Jie Li , Ziqiu Lai , Kai Chen . Unveiling the Mystery of Chirality from Tartaric Acid. University Chemistry, 2024, 39(9): 369-378. doi: 10.12461/PKU.DXHX202310091
9. [9]
  Liwei Wang , Guangran Ma , Li Wang , Fugang Xu . A Comprehensive Analytical Chemistry Experiment: Colorimetric Detection of Vitamin C Using Nanozyme and Smartphone. University Chemistry, 2024, 39(8): 255-262. doi: 10.3866/PKU.DXHX202312094
10. [10]
  Xilin Zhao , Xingyu Tu , Zongxuan Li , Rui Dong , Bo Jiang , Zhiwei Miao . Research Progress in Enantioselective Synthesis of Axial Chiral Compounds. University Chemistry, 2024, 39(11): 158-173. doi: 10.12461/PKU.DXHX202403106
11. [11]
  Zhuomin Zhang , Hanbing Huang , Liangqiu Lin , Jingsong Liu , Gongke Li . Course Construction of Instrumental Analysis Experiment: Surface-Enhanced Raman Spectroscopy for Rapid Detection of Edible Pigments. University Chemistry, 2024, 39(2): 133-139. doi: 10.3866/PKU.DXHX202308034
12. [12]
  Ke QIAO , Yanlin LI , Shengli HUANG , Guoyu YANG . Advancements in asymmetric catalysis employing chiral iridium (ruthenium) complexes. Chinese Journal of Inorganic Chemistry, 2024, 40(11): 2091-2104. doi: 10.11862/CJIC.20240265
13. [13]
  Wei Shao , Wanqun Zhang , Pingping Zhu , Wanqun Hu , Qiang Zhou , Weiwei Li , Kaiping Yang , Xisheng Wang . Design and Practice of Ideological and Political Cases in the Course of Instrument Analysis Experiment: Taking the GC-MS Experiment as an Example. University Chemistry, 2024, 39(2): 147-154. doi: 10.3866/PKU.DXHX202309048
14. [14]
  Jingyi Chen , Fu Liu , Tiejun Zhu , Kui Cheng . Practice of Integrating Ideological and Political Education into Raman Spectroscopy Analysis Experiment Course. University Chemistry, 2024, 39(2): 140-146. doi: 10.3866/PKU.DXHX202310111
15. [15]
  Yifan Xie , Liyun Yao , Ruolin Yang , Yuxing Cai , Yujie Jin , Ning Li . Application of Comparative Pedagogy in Instrumental Analysis Experiment Teaching. University Chemistry, 2024, 39(3): 266-273. doi: 10.3866/PKU.DXHX202309068
16. [16]
  Min Gu , Huiwen Xiong , Liling Liu , Jilie Kong , Xueen Fang . Rapid Quantitative Detection of Procalcitonin by Microfluidics: An Instrumental Analytical Chemistry Experiment. University Chemistry, 2024, 39(4): 87-93. doi: 10.3866/PKU.DXHX202310120
17. [17]
  Tianlong Zhang , Jiajun Zhou , Hongsheng Tang , Xiaohui Ning , Yan Li , Hua Li . Virtual Simulation Experiment for Laser-Induced Breakdown Spectroscopy (LIBS) Analysis. University Chemistry, 2024, 39(6): 295-302. doi: 10.3866/PKU.DXHX202312049
18. [18]
  Zunxiang Zeng , Yuling Hu , Yufei Hu , Hua Xiao . Analysis of Plant Essential Oils by Supercritical CO₂Extraction with Gas Chromatography-Mass Spectrometry: An Instrumental Analysis Comprehensive Experiment Teaching Reform. University Chemistry, 2024, 39(3): 274-282. doi: 10.3866/PKU.DXHX202309069
19. [19]
  Lijun Dong , Pengcheng Du , Guangnong Lu , Wei Wang . Exploration and Practice of Independent Design Experiments in Inorganic and Analytical Chemistry: A Case Study of “Preparation and Composition Analysis of Tetraammine Copper(II) Sulfate”. University Chemistry, 2024, 39(4): 361-366. doi: 10.3866/PKU.DXHX202310041
20. [20]
  Yan Li , Fei Ding , Jing Wang , Jing Nan , Yijun Li , Xiaohang Qiu . Give a Man a Fish, and Teach a Man to Fish: Self-Designed Instrumental Analysis Experiments and Integration of Ideological and Political Elements. University Chemistry, 2024, 39(2): 208-213. doi: 10.3866/PKU.DXHX202310097

Get Citation

PDF

XML

Metrics

PDF Downloads(1)
Abstract views(487)
HTML views(50)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Address：Zhongguancun North First Street 2,100190 Beijing, PR China Tel: +86-010-82449177-888

DownLoad: Full-Size Img PowerPoint

Return