Citation: Lu Gao, Zhiwen Chu, Guobo Li. Building Cutting-Edge Case Studies for New Drug Development Based on Medicinal Chemistry Course Content: Teaching Examples for the Cardiovascular Drugs Chapter[J]. University Chemistry, ;2023, 38(12): 25-31. doi: 10.3866/PKU.DXHX202306042 shu

Building Cutting-Edge Case Studies for New Drug Development Based on Medicinal Chemistry Course Content: Teaching Examples for the Cardiovascular Drugs Chapter

West China School of Pharmacy, Sichuan University, Chengdu 610041, China

Corresponding author: Guobo Li, liguobo@scu.edu.cn
Received Date: 23 June 2023

Medicinal chemistry, as a fundamental course in undergraduate pharmacy programs, serves as the cornerstone of innovative drug research. Enhancing the timeliness, innovation, and advanced nature of medicinal chemistry teaching content to meet the demands of talent development in contemporary pharmaceutical innovation is a challenge warranting deep consideration and exploration. This paper, grounded in the teaching content of the cardiovascular system drugs chapter, constructs course cases that incorporate the frontiers of the discipline, interdisciplinary studies, and curriculum-based ideological and political education. It aims to provide new materials and perspectives for teaching in medicinal chemistry and related fields.
- Medicinal chemistry,
- Case-based teaching,
- Discipline crossing,
- Academic frontier,
- Cardiovascular drugs
1. [1]
2. [2]
  Liang, G.-Q.; Deng, J.; Wu, C.-X.; Li, W.-J.; Hu, Y.-F.; Song, Y.-Q.; Yin, X.-C.; He, Q.; Xiao, Y.-C.; Li, G.-B. J. Chem. Educ. 2023, 100 (2), 803.
3. [3]
4. [4]
5. [5]
6. [6]
  Yu, J.-L.; Wu, S.; Zhou, C.; Dai, Q.-Q.; Schofield, C. J.; Li, G.-B. Nucleic Acids Res. 2022, 51 (D1), D593.
7. [7]
8. [8]
9. [9]
  Congreve, M.; de Graaf, C.; Swain, N. A.; Tate, C. G. Cell 2020, 181 (1), 81.
10. [10]
  Sadybekov, A. A.; Sadybekov, A. V.; Liu, Y.; Iliopoulos-Tsoutsouvas, C.; Huang, X.-P.; Pickett, J.; Houser, B.; Patel, N.; Tran, N. K.; Tong, F. et al. Nature 2022, 601 (7893), 452.
11. [11]
  Theodoris, C. V.; Xiao, L.; Chopra, A.; Chaffin, M. D.; Al Sayed, Z. R.; Hill, M. C.; Mantineo, H.; Brydon, E. M.; Zeng, Z.; Liu, X. S. et al. Nature 2023, 618 (7965), 616.
12. [12]
13. [13]
  The Nobel Prize in Chemistry 2001. NobelPrize.org. Nobel Prize Outreach AB 2023. [2023-06-08]. https://www.nobelprize.org/prizes/chemistry/2001/summary/
14. [14]
  The Nobel Prize in Chemistry 2021. NobelPrize.org. Nobel Prize Outreach AB 2023. [2023-06-08] https://www.nobelprize.org/prizes/chemistry/2021/summary/
15. [15]
16. [16]
17. [17]
18. [18]
19. [19]
  Baumann, M.; Baxendale, I. R. Beilstein J. Org. Chem. 2015, 11, 1194.
20. [20]
  Porta, R.; Benaglia, M.; Puglisi, A. Org. Process Res. Dev. 2016, 20 (1), 2.
21. [21]
  De Vitis, V.; Dall'Oglio, F.; Pinto, A.; De Micheli, C.; Molinari, F.; Conti, P.; Romano, D.; Tamborini, L. ChemistryOpen 2017, 6 (5), 668.
22. [22]
  Zhu, J.; Bienaymé, H. Multicomponent Reactions, 1st ed.; Wiley‐VCH: Weinheim, Gemany, 2005; p. 1.
23. [23]
  Nagarajaiah, H.; Mukhopadhyay, A.; Moorthy, J. N. Tetrahedron Lett. 2016, 57 (47), 5135.
24. [24]
  Zohny, Y. M.; Awad, S. M.; Rabie, M. A.; Al-Saidan, O. A. Molecules 2023, 28 (2), 784.
25. [25]
  Aboul-Enein, Y. H.; Kannappan, V.; Kanthiah, S. Comb. Chem. High T. Scr. 2023, 26, 1.
26. [26]
  Chen, F.; Bai, Q.; Wang, Q.; Chen, S.; Ma, X.; Cai, C.; Wang, D.; Waqas, A.; Gong, P. Curr. Pharm. Biotechno. 2020, 21 (15), 1632.
27. [27]
  Hancu, G.; Modroiu, A. Pharmaceuticals 2022, 15 (2), 240.
28. [28]
29. [29]
30. [30]
  Shepherd, J.; Blauw, G. J.; Murphy, M. B.; Bollen, E. L. E. M.; Buckley, B. M.; Cobbe, S. M.; Ford, I.; Gaw, A.; Hyland, M.; Jukema, J. W. et al. Lancet 2002, 360 (9346), 1623.
31. [31]
32. [32]
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