研究型分析化学综合实验教学模式探究——以“海藻酸盐微胶囊的制备、药物包封及缓控释分析实验”为例

引用本文: 胡国梁, 颜鑫灏, 陈睿希, 刘红瑜, 姚奇志, 李娇, 李玲玲. 研究型分析化学综合实验教学模式探究——以“海藻酸盐微胶囊的制备、药物包封及缓控释分析实验”为例[J]. 大学化学, 2024, 39(1): 134-141. doi: 10.3866/PKU.DXHX202305088 shu

Citation: Guoliang Hu, Xinhao Yan, Ruixi Chen, Hongyu Liu, Qizhi Yao, Jiao Li, Lingling Li. Exploring the Teaching Model of Research-Oriented Comprehensive Experimental Analysis in Analytical Chemistry: A Case Study of “Preparation of Alginate Microcapsules, Drug Encapsulation, and Sustained Controlled Release Analysis Experiment”[J]. University Chemistry, 2024, 39(1): 134-141. doi: 10.3866/PKU.DXHX202305088 shu

研究型分析化学综合实验教学模式探究——以“海藻酸盐微胶囊的制备、药物包封及缓控释分析实验”为例

1.
化学国家级实验教学示范中心(中国科学技术大学), 合肥 230026;
2.
中国科学技术大学化学与材料科学学院, 合肥 230026

通讯作者: 刘红瑜,Email:liuhyhx@ustc.edu.cn

基金项目:
2021年安徽省课程思政建设示范中心（2021kcszsfzx028）；中国科学技术大学2021年校级课程思政研究项目（2021xkcszxm02）

摘要: “海藻酸盐微胶囊的制备、药物包封及缓控释分析实验”是II型分析化学实验中非常典型的一个研究型实验，它涵盖了微胶囊形成原理探究、实验条件设计、微胶囊性能表征等科研基本能力的训练。将海藻酸钠与亚甲基蓝混合溶液分别滴加至3% CaCl₂溶液和1%壳聚糖溶液中，从而制备出两种不同性能的微胶囊。通过分光光度法测得不同时间溶液的浓度，从而得到缓释曲线，并对两种胶囊的缓释性进行对比分析。后续探究实验采用一步法和两步法制备微胶囊，将两种体系的优点结合起来，得到缓释性和稳定性均较好的微胶囊。

关键词:

English

Exploring the Teaching Model of Research-Oriented Comprehensive Experimental Analysis in Analytical Chemistry: A Case Study of “Preparation of Alginate Microcapsules, Drug Encapsulation, and Sustained Controlled Release Analysis Experiment”

1.
National Demonstration Center for Experimental Chemistry Education (University of Science and Technology of China), Hefei 230026, China;
2.
School of Chemistry and Materials Science, University of Science and Technology of China, Hefei 230026, China

Corresponding author: Hongyu Liu, liuhyhx@ustc.edu.cn

Received Date: 31 May 2023

Abstract: The "Alginate microcapsule preparation, drug encapsulation, and sustained controlled release analysis experiment" serves as a prominent research-oriented experiment within Type II analytical chemistry experiments. It encompasses essential training in basic scientific research skills, including the exploration of microcapsule formation principles, experimental condition design, and microcapsule performance characterization. In this experiment, a mixed solution of sodium alginate and methylene blue was dropped into 3% CaCl₂ solution and 1% chitosan solution, respectively, resulting in the preparation of two microcapsules with distinct properties. The concentration of the solution was measured at various time intervals using spectrophotometry to derive sustained-release curves, facilitating a comparative analysis of the sustained-release properties of the two microcapsules. Additionally, a subsequent exploration experiment employed both one-step and two-step methods for microcapsule preparation, combining the advantages of both systems to achieve microcapsules with optimal sustained-release and stability characteristics.

Key words:

1. [1]
  刘红瑜, 张晨龙, 江伟韬, 刘立岩, 邢伟龙, 金谷, 姚奇志, 李娇, 王晓葵, 李玲玲. 大学化学, 2020, 35 (2), 33.
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  金谷, 姚奇志, 江万权, 胡祥余, 李娇. 分析化学实验. 第1版. 合肥: 中国科学技术大学出版社, 2010: 192.
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  李成魁, 祁红璋, 严彪. 上海金属, 2009, 7 (4), 54.
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  林永波, 邢佳, 孙伟光. 环境科学与管理, 2007, No. 9, 85.
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  秦润华, 姜炜, 刘宏英, 李凤生. 材料导报, 2003, 9 (17), 66.
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  史同瑞, 王丽坤, 张莹, 王岩, 骆宏伟, 鹿凌岩, 于万才. 黑龙江畜牧兽医, 2018, No. 3, 87.
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  Daly, M. M.; Knorr, D. Biotechnol. Progr. 1988, 4 (2), 76.Daly, M. M.; Knorr, D. Biotechnol. Progr. 1988, 4 (2), 76.

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研究型分析化学综合实验教学模式探究——以“海藻酸盐微胶囊的制备、药物包封及缓控释分析实验”为例

通讯作者: 刘红瑜,Email:liuhyhx@ustc.edu.cn

English

Exploring the Teaching Model of Research-Oriented Comprehensive Experimental Analysis in Analytical Chemistry: A Case Study of “Preparation of Alginate Microcapsules, Drug Encapsulation, and Sustained Controlled Release Analysis Experiment”

Corresponding author: Hongyu Liu, liuhyhx@ustc.edu.cn

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通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

研究型分析化学综合实验教学模式探究——以“海藻酸盐微胶囊的制备、药物包封及缓控释分析实验”为例

通讯作者: 刘红瑜,Email:liuhyhx@ustc.edu.cn

English

Exploring the Teaching Model of Research-Oriented Comprehensive Experimental Analysis in Analytical Chemistry: A Case Study of “Preparation of Alginate Microcapsules, Drug Encapsulation, and Sustained Controlled Release Analysis Experiment”

Corresponding author: Hongyu Liu, liuhyhx@ustc.edu.cn

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南： 你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

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