Citation: Tianyu Li, Danqing Wu, Jiajun Liu, Dazhen Xu, Zhiwei Miao. Research Progress of Asymmetric C―H/C―H Cross Dehydrogenation Coupling Reaction[J]. University Chemistry, ;2023, 38(12): 165-180. doi: 10.3866/PKU.DXHX202305034 shu

Research Progress of Asymmetric C―H/C―H Cross Dehydrogenation Coupling Reaction

State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China

Corresponding author: Dazhen Xu, Zhiwei Miao,
Received Date: 8 May 2023

In recent years, the cross-dehydrogenative coupling (CDC) reaction has received widespread attention in the field of organic synthetic chemistry. This strategy avoids the pre-functionalization of substrates in the reactions that form carbon-carbon bonds. It demonstrates high atomic economy and aligns with the development requirements of green chemistry. Furthermore, asymmetric CDC reactions can realize stereoselective construction of carbon-carbon bonds, which currently constitutes a key area of research in organic synthesis. This paper reviews the research progress in asymmetric CDC reactions and provides a perspective on the future development direction in this field.
- Asymmetric catalysis,
- Green chemistry,
- C―H activation,
- C―C bond formation,
- Research progress
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