Citation: Laiying Zhang, Hongyu Gou, Haini Zhuang, Yuhang Qin, Huijuan Qiu, Weitai Wu. Construction and Characterization of Intelligent, Controlled Drug Release Visualization Systems: A New Design and Teaching Practice of Polymer Experiments[J]. University Chemistry, ;2023, 38(12): 212-219. doi: 10.3866/PKU.DXHX202304094 shu

Construction and Characterization of Intelligent, Controlled Drug Release Visualization Systems: A New Design and Teaching Practice of Polymer Experiments

College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, Fujian Province, China

Corresponding author: Laiying Zhang, Weitai Wu,
Received Date: 26 April 2023

This study presents a new experimental design and teaching practice for polymer chemistry, physical chemistry, and instrument analysis. Here, a type of thermosensitive polymer microgel was synthesized in an aqueous solution by free radical precipitation polymerization. The thermo-responsivity of these microgels was assessed using a UV-Vis spectrophotometer and dynamic light scattering instrument. These microgels were then utilized as carriers to construct a controlled drug delivery system, in which the drug was uploaded to the microgels in the swollen state and released from the microgels in the collapsed state. To understand the drug release process, a combination of color theory and chemical knowledge was proposed, in which the drug with visible range absorption was selected to "visualize" the drug release process, making it more intuitive and observable. Based on this perceptual understanding, the molecular diffusion mechanism of the drug release process was analyzed rationally. This experiment was based on cutting-edge green research results that have been widely investigated and verified. Moreover, this experiment, which can be extended to other responsive polymers and drugs, has universal applicability. This experiment can not only exercise basic operational ability but also help develop research skills for identifying and solving problems and improve students’ innovation ability.
- Thermo-sensitive microgels,
- Free radical precipitation polymerization,
- Controlled drug release system,
- Visual detection,
- Experimental teaching
1. [1]
  Sohail, M. F.; Rehman, M.; Sarwar, H. S.; Naveed, S.; Salman, O.; Bukhari, N. I.; Hussain, S.; Webster, T. J.; Shahnaz, G. Int. J. Nanomed. 2018, 13, 3145.
2. [2]
  Ryany, F. D.; Paul, A. M.; David, W. Recent Pat. Drug. Deliv. Formul. 2009, 3, 1.
3. [3]
  Kang, J.; Hwang, J.; Seo, J.; Kim, H.; Shin, U. S. Mater. Sci. Eng. C-Mater. Biol. Appl. 2018, 91, 247.
4. [4]
5. [5]
  Huang, G.; Gao, J.; Hu, Z. B.; John, V. J.; Bill, C. P.; Dan, M. J. Control. Release 2003, 94 (2), 303.
6. [6]
  Zhang, Y. S.; Khademhosseini, A. Science 2017, 356, 500.
7. [7]
  Tanaka, T.; Fillmore, D. J. J. Chem. Phys. 1979, 70 (3), 1214.
8. [8]
  Ji, X. F.; Shi, B. B.; Wang, H.; Xia, D. Y.; Jie, J. K.; Wu, Z. L.; Huang, F. H. Adv. Mater. 2015, 27 (48), 8062.
9. [9]
  Kim, D. R.; Napper, D. H. Macromol. Rapid Commun. 1996, 17 (12), 845.
10. [10]
  Napper, D. H.; Netschey, A.; Alexander, A. E. J. Polym. Sci. Pol. Chem. 1971, 9 (1), 81.
11. [11]
  Napper, D. H.; Alexander, A. J. Polym. Sci. 1962, 61 (171), 127.
12. [12]
  Roseman, T. J.; Higuchi, W. I. J. Pharm. Sci. 1979, 59 (3), 353.
13. [13]
  Siepmann, J.; Peppas, N. A. Adv. Drug Deliv. Rev. 2001, 48, 139.
14. [14]
1. [1]
  Bin Wang , Chuanli Qin , Naiying Fan , Zhibin Li , Zhibiao Zhu , Jiancong Liu , Shaoping Sun . Construction and Practice of Digital Platform and Teaching Resources of Chemistry Experimental Teaching Center: A Case Study of Provincial Demonstration Center for Experimental Chemistry Education (Heilongjiang University). University Chemistry, 2024, 39(7): 193-199. doi: 10.12461/PKU.DXHX202405116
2. [2]
  Xiaohui Li , Ze Zhang , Jingyi Cui , Juanjuan Yin . Advanced Exploration and Practice of Teaching in the Experimental Course of Chemical Engineering Thermodynamics under the “High Order, Innovative, and Challenging” Framework. University Chemistry, 2024, 39(7): 368-376. doi: 10.3866/PKU.DXHX202311027
3. [3]
  Laiying Zhang , Yinghuan Wu , Yazi Yu , Yecheng Xu , Haojie Zhang , Weitai Wu . Innovation and Practice of Polymer Chemistry Experiment Teaching for Non-Polymer Major Students of Chemistry: Taking the Synthesis, Solution Property, Optical Performance and Application of Thermo-Sensitive Polymers as an Example. University Chemistry, 2024, 39(4): 213-220. doi: 10.3866/PKU.DXHX202310126
4. [4]
  Wenjun Yang , Qiaoling Tan , Wenjiao Xie , Xiaoyu Pan , Youyong Yuan . Construction and Characterization of Calcium Alginate Microparticle Drug Delivery System: A Novel Design and Teaching Practice in Polymer Experiments. University Chemistry, 2025, 40(3): 371-380. doi: 10.12461/PKU.DXHX202405150
5. [5]
  Tingyu Zhu , Hui Zhang , Wenwei Zhang . Exploration and Practice of Ideological and Political Education in the Course of Experiments on Chemical Functional Molecules: Synthesis and Catalytic Performance Study of Chiral Mn(III)Cl-Salen Complex. University Chemistry, 2024, 39(4): 75-80. doi: 10.3866/PKU.DXHX202311011
6. [6]
  Xin Lv , Hongxing Zhang , Kaibo Duan , Wenhui Dai , Zhihui Wen , Wei Guo , Junsheng Hao . Lighting the Way Against Cancer: Photodynamic Therapy. University Chemistry, 2024, 39(5): 70-79. doi: 10.3866/PKU.DXHX202309090
7. [7]
  Haorui Gu , Ning Li , Zhanxiang Liu , Xufeng Lin . Construction and Development of Chemistry Experimental Teaching Center under the Background of the “101 Plan”. University Chemistry, 2024, 39(7): 110-115. doi: 10.12461/PKU.DXHX202405022
8. [8]
  Yan Zhao , Weiping Luo , Haoran Liu , Yongqing Kuang , Zhaoyang Wu , Weijun Yang , Yongjun Li , Dongcai Guo . Construction and Practice of the Chemistry and Chemical Engineering Experimental Teaching Center of Hunan University. University Chemistry, 2024, 39(7): 147-152. doi: 10.12461/PKU.DXHX202405059
9. [9]
  Dongcheng Liu , Xiaokun Li , Huancheng Hu , Cunji Gao , Qiong Hu , Shuting Li , Yuning Liang . Chemistry Experimental Teaching Reform for the Promotion of Training Exceptional Chemistry Teachers for Normal Schools. University Chemistry, 2024, 39(8): 1-6. doi: 10.3866/PKU.DXHX202311072
10. [10]
  Zunyuan Xie , Lijin Yang , Zixiao Wan , Xiaoyu Liu , Yushan He . Exploration of the Preparation and Characterization of Nano Barium Titanate and Its Application in Inorganic Chemistry Laboratory Teaching. University Chemistry, 2024, 39(4): 62-69. doi: 10.3866/PKU.DXHX202310137
11. [11]
  Wei Zhang , Kunying Xing , Wei Li , Yan Geng , Bo Tang . Construction and Practice of National Experimental Teaching Demonstration Center of Chemistry (Shandong Normal University). University Chemistry, 2024, 39(7): 20-25. doi: 10.12461/PKU.DXHX202404059
12. [12]
  Heng Zhang , Gang Liu , Zhenghu Xu , Ying Ma . Construction and Practice of Comprehensive Open and Innovative Chemistry Experimental Teaching System and Platform in the Context of Multidisciplinary Integration. University Chemistry, 2024, 39(7): 56-63. doi: 10.12461/PKU.DXHX202405001
13. [13]
  Zhangshu Wang , Xin Zhang , Jixin Han , Xuebing Fang , Xiufeng Zhao , Zeyu Gu , Jinjun Deng . Exploration and Design of Experimental Teaching on Ultrasonic-Enhanced Synergistic Treatment of Ternary Composite Flooding Produced Water. University Chemistry, 2024, 39(5): 116-124. doi: 10.3866/PKU.DXHX202310056
14. [14]
  Zhenlin Zhou , Siyuan Chen , Yi Liu , Chengguo Hu , Faqiong Zhao . A New Program of Voltammetry Experiment Teaching Based on Laser-Scribed Graphene Electrode. University Chemistry, 2024, 39(2): 358-370. doi: 10.3866/PKU.DXHX202308049
15. [15]
  Dongxue Han , Zhuoyong Li , Hanbo Zou , Xu Wu , Yang Yuan , Hongbin Li . Research on Innovative Experimental Teaching to Cultivate Top Talents. University Chemistry, 2024, 39(7): 230-236. doi: 10.12461/PKU.DXHX202406094
16. [16]
  Yeyun Zhang , Ling Fan , Yanmei Wang , Zhenfeng Shang . Development and Application of Kinetic Reaction Flasks in Physical Chemistry Experimental Teaching. University Chemistry, 2024, 39(4): 100-106. doi: 10.3866/PKU.DXHX202308044
17. [17]
  Dexin Tan , Limin Liang , Baoyi Lv , Huiwen Guan , Haicheng Chen , Yanli Wang . Exploring Reverse Teaching Practices in Physical Chemistry Experiment Courses: A Case Study on Chemical Reaction Kinetics. University Chemistry, 2024, 39(11): 79-86. doi: 10.12461/PKU.DXHX202403048
18. [18]
  Zhonghua Xi , Xuanfeng Kong , Jinyue Yang , Bin Liu , Tingyu Zhu , Hui Zhang , Wenwei Zhang . Construction of Public Teaching Instrument Platform and Exploration of Opening Mechanism. University Chemistry, 2024, 39(7): 200-206. doi: 10.12461/PKU.DXHX202405123
19. [19]
  Zhihui Wen , Zhanheng Feng , Xue Qi , Xiaohang Qiu . Exploration and Practice in Inorganic Chemistry Laboratory Management under Broad-based Admission Programs. University Chemistry, 2024, 39(6): 181-188. doi: 10.3866/PKU.DXHX202310081
20. [20]
  Zhongbin Pan , Shijie Huang , Yunjie Luo , Hongzhen Xie . Design of a Comprehensive Experiment for Determining Permanganate Index (COD_Mn) in Drinking Water. University Chemistry, 2024, 39(7): 354-360. doi: 10.12461/PKU.DXHX202311040

Get Citation

PDF

XML

Metrics

PDF Downloads(1)
Abstract views(570)
HTML views(83)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142