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Citation: Jianjun Chen, Yueyang Cao, Wanhong Chen, Guosheng Huang, Kun Gao. Side Reaction Products Analysis of Organic Chemistry Experiments to Guide Experimental Innovation and Improve Scientific Research Literacy: Synthesis of 4-Phenylbutyl-2-ketone[J]. University Chemistry, ;2023, 38(11): 223-229. doi: 10.3866/PKU.DXHX202304058 shu

Side Reaction Products Analysis of Organic Chemistry Experiments to Guide Experimental Innovation and Improve Scientific Research Literacy: Synthesis of 4-Phenylbutyl-2-ketone

College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China

Corresponding author: Jianjun Chen, Guosheng Huang, Kun Gao,
Received Date: 18 April 2023

The synthesis of 4-phenyl buty-2-ketone from ethyl acetoacetate and benzyl chloride is a classical organic chemistry experiment, but the yield is only 20%-30% in practical teaching. This paper records the process of teachers guiding students to separate the byproduct in the experiment, determines it as 2,2-dibenzyl-3-oxybutyrate, analyzes the causes of the byproduct, and inspires the students to innovate the experimental method to increase the yield to 57.5%. This teaching practice not only guides students with regard to experimental innovation but also improves the scientific research literacy of students.
- 4-Phenyl buty-2-ketone,
- Experimental innovation,
- Improvement of reaction yield,
- Scientific research literacy
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