Citation: Jing Cheng, Xueping Yang, Jian Jin, Peng Ren. An Experimental Teaching Design for Learning Hammett Equation Using Suzuki Coupling Reaction[J]. University Chemistry, ;2023, 38(9): 272-279. doi: 10.3866/PKU.DXHX202211040 shu

An Experimental Teaching Design for Learning Hammett Equation Using Suzuki Coupling Reaction

Jing Cheng ¹ ,
Xueping Yang ¹ ,
Jian Jin ¹ ,
Peng Ren ^1,2,,

1.
Experiment and Innovation Education Center, Harbin Institute of Technology (Shenzhen), Shenzhen 518055, Guangdong Province, China;
2.
School of Science, Harbin Institute of Technology (Shenzhen), Shenzhen 518055, Guangdong Province, China

Corresponding author: Peng Ren, renpeng@hit.edu.cn
Received Date: 15 November 2022

This study introduced an innovative, comprehensive experiment of organic chemistry — “the experimental teaching scheme of learning the Hammett equation by Suzuki coupling reaction”. The relationship curve of the Hammett equation was further obtained by exploring the influence of different substituted substrates on the reaction rate of the Suzuki coupling reaction. The results showed that the reaction rate was slowed down by the electron-withdrawing substituents on phenylboronic acid and accelerated by the electron-donating substituents. The influence of the metallization process on the Suzuki coupling reaction was also explored. In the process of literature research, experimental design, experimental operation, result analysis and report writing, students can learn the basic principle of Suzuki coupling reaction and understand the significance of the Hammett equation. The comprehensive experimental project is helpful to stimulate students' interest in scientific research of organic chemistry and improve their comprehensive quality.
- Suzuki coupling reaction,
- Hammett equation,
- Reaction mechanism,
- Innovative experiment
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