Citation: Bo Yuan, Chenyun Feng, Yaofeng Yuan. Research Progress on Small-Molecule Drugs for Treating COVID-19[J]. University Chemistry, ;2023, 38(8): 85-94. doi: 10.3866/PKU.DXHX202208060 shu

Research Progress on Small-Molecule Drugs for Treating COVID-19

Bo Yuan ² ,
Chenyun Feng ^1,3,, ,
Yaofeng Yuan ^1,,

1.
College of Chemistry, Fuzhou University, Fuzhou 350108, China;
2.
National Medical Products Administration Southern Medical Economy Institute, Guangzhou 510080, China;
3.
Department of Chemistry, Southern University of Science and Technology, Shenzhen 518055, Guangdong Province, China

Corresponding author: Chenyun Feng, Yaofeng Yuan,
Received Date: 9 August 2022

The COVID-19 pandemic has caused significant losses and suffering around the world. Although the SARS-CoV-2 vaccine has largely controlled the spread of the virus, the scientific and sustainable treatment of COVID-19 patients is still necessary to truly end the pandemic. Small-molecule drugs against COVID-19 have attracted the attention of the scientific community and industry owing to their unique advantages such as a simple delivery method, relatively high output, and immune response with lower probability. Fortunately, in the last three years, some potentially effective drugs have been proposed, and have achieved good results in clinical trials. This paper briefly introduces the research progress on small-molecule drugs since 2020 to provide reference for future SARS-CoV-2 research.
- SARS-CoV-2,
- Small molecule drugs,
- RdRp,
- Azvudine,
- Paxlovid^TM
1. [1]
  Zhao, D. H.; Yao, F. F.; Wang, L. J.; Zheng, L.; Gao, Y. J.; Ye, J.; Guo, F.; Zhao, H.; Gao, R. B. Clin. Infect. Dis. 2020, 71, 756.
2. [2]
  Chan, J. F. W.; Yip, C. C. Y.; To, K. K. W.; Tang, T. H. C.; Wong, S. C. Y.; Leung, K. H.; Fung, A. Y. F.; Ng, A. C. K.; Zou, Z. J.; Tsoi, H. W.; et al. J. Clin. Microbiol. 2020, 58, e00310.
3. [3]
  Weekly epidemiological update on COVID-19.[2022-11-21].https://www.who.int/publications/m/item/weekly-epidemiological-update-on-covid-19——16-november-2022
4. [4]
  Douin, D. J.; Talbot, H. K.; Casey, J. D.; Mohr, N. M.; Zepeski, A.; Shapiro, N. I.; Gibbs, K. W.; Files, D. C.; Hager, D. N.; Shehu, A.; et al.BMJ-Brit. Med. J. 2022, 376, e069761.
5. [5]
  Fiolet, T.; Kherabi, Y.; MacDonald, C. J.; Ghosn, J.; Peiffer-Smadja, N. Clin. Microbiol. Infect. 2022, 28, 202.
6. [6]
7. [7]
  Barbier, A. J.; Jiang, A. Y. J.; Zhang, P.; Wooster, R.; Anderson, D. G. Nat. Biotechnol. 2022, 40, 840.
8. [8]
  CY 2021 CDER New Molecular Entity (NME) Drug & Original BLA Calendar Year Approvals As of December 31, 2021.[2022-10-09]. https://www.fda.gov/media/158152/download
9. [9]
  Emergency Use Authorization.[2022-10-09].https://www.fda.gov/emergency-preparedness-and-response/mcm-legal-regulatory-and-policy-framework/emergency-use-authorization#coviddrugs
10. [10]
  Drugs@FDA:FDA-Approved Drugs.[2022-10-09]. https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=reportsSearch.process
11. [11]
  Gordon, D. E.; Jang, G. M.; Bouhaddou, M.; Xu, J. W.; Obernier, K.; White, K. M.; O'Meara, M. J.; Rezelj, V. V.; Guo, J. F. Z.; Swaney, D. L.;et al. Nature 2020, 583, 459.
12. [12]
  Ho, W. S.; Zhang, R. R.; Tan, Y. L.; Chai, C. L. L. Pharmacol. Res. 2022, 179, 106201.
13. [13]
  Saha, A.; Sharma, A. R.; Bhattacharya, M.; Sharma, G.; Lee, S. S.; Chakraborty, C. Arch. Med. Res. 2020, 51, 585.
14. [14]
  Subissi, L.; Posthuma, C. C.; Collet, A.; Zevenhoven-Dobbe, J. C.; Gorbalenya, A. E.; Decroly, E.; Snijder, E. J.; Canard, B.; Imbert, I.Proc. Natl. Acad. Sci. USA 2014, 111, E3900.
15. [15]
16. [16]
  China approves first homegrown COVID antiviral.[2022-08-01]. https://www.nature.com/articles/d41586-022-02050-x
17. [17]
  Zhang, J. L.; Li, Y. H.; Wang, L. L.; Liu, H. Q.; Lu, S. Y.; Liu, Y.; Li, K.; Liu, B.; Li, S. Y.; Shao, F. M.; et al. Signal Transduct. Target. Ther.2021, 6 (1), 414.
18. [18]
  Chang, J. B. Acc. Chem. Res. 2022,55, 565.
19. [19]
  Yu, B.; Chang, J. B. Signal Transduct. Target. Ther. 2020,5, 236.
20. [20]
  Ren, Z. G.; Luo, H.; Yu, Z. J.; Song, J. C.; Liang, L.; Wang, L.; Wang, H. Y.; Cui, G. Y.; Liu, Y.; Wang, J.; et al. Adv. Sci. 2020,7, 2001435.
21. [21]
  Tang, W.; Cao, Z. J.; Han, M. F.; Wang, Z. Y.; Chen, J. W.; Sun, W. J.; Wu, Y. J.; Xiao, W.; Liu, S. Y.; Chen, E. Z.; et al. BMJ-Brit. Med. J. 2020, 369, m1849.
22. [22]
23. [23]
  Khiali, S.; Khani, E.; Rouy, S. B.; Rouy, S. B.; Entezari-Maleki, T. Future Microbiol. 2022, 17, 377.
24. [24]
  Kabinger, F.; Stiller, C.; Schmitzoval, J.; Dienemann, C.; Kokic, G.; Hillen, H. S.; Hobartner, C.; Cramer, P. Nat. Struct. Mol. Biol. 2021,28, 740.
25. [25]
  Painter, W. P.; Holman, W.; Bush, J. A.; Almazedi, F.; Malik, H.; Eraut, N.; Morin, M. J.; Szewczyk, L. J.; Painter, G. R. Antimicrob. Agents Chemother. 2021, 65, e02428-20.
26. [26]
  Fischer, W. A.; Eron, J. J.; Holman, W.; Cohen, M. S.; Fang, L.; Szewczyk, L. J.; Sheahan, T. P.; Baric, R.; Mollan, K. R.; Wolfe, C. R.; et al.Sci. Transl. Med. 2022, 14, eabl7430.
27. [27]
  Thorlund, K.; Sheldrick, K.; Mills, E. N. Engl. J. Med. 2022,386, e32.
28. [28]
  Beigel, J. H.; Tomashek, K. M.; Dodd, L. E.; Mehta, A. K.; Zingman, B. S.; Kalil, A. C.; Hohmann, E.; Chu, H. Y.; Luetkemeyer, A.; Kline, S.;et al. N. Engl. J. Med. 2020, 383, 1813.
29. [29]
  Ader, F.; Bouscambert-Duchamp, M.; Hites, M.; Peiffer-Smadja, N.; Mentre, F.; Burdet, C.; DisCoVeRy Study Group Lancet Infect. Dis. 2022,22, 764.
30. [30]
  Hammond, J.; Leister-Tebbe, H.; Gardner, A.; Abreu, P.; Bao, W. H.; Wisemandle, W.; Baniecki, M.; Hendrick, V. M.; Damle, B.; Simon-Campos, A.; et al. N. Engl. J. Med. 2022,386, 1397.
31. [31]
  Lee, J. T.; Yang, Q. Y.; Gribenko, A.; Perrin, B. S.; Zhu, Y. A.; Cardin, R.; Liberator, P. A.; Anderson, A. S.; Hao, L. MBIO 2022, 7, 00867.
32. [32]
  Mahdi, M.; Motyan, J. A.; Szojka, Z. I.; Golda, M.; Miczi, M. Virol. J. 2020, 17, 190.
33. [33]
  Zwart, D. Trop. Geogr. Med. 2003, 914, 340.
34. [34]
  Vohra, M.; Sharma, A. R.; Satyamoorthy, K.; Rai, P. S. Pers. Med. 2021, 18, 389.
35. [35]
  Mahmudpour, M.; Roozbeh, J.; Keshavarz, M.; Farrokhi, S.; Nabipour, I. l. Cyokine 2020, 133, 155151.
36. [36]
  Sinha, S.; Rosin, N. L.; Arora, R.; Labit, E.; Jaffer, A.; Cao, L. L.; Farias, R.; Nguyen, A. P.; de Almeida, L. G. N.; Dufour, A.; et al. Nat. Med. 2022, 28, 201.
37. [37]
  Giles, A. J.; Hutchinson, M.; Sonnemann, H. M.; Jung, J.; Fecci, P. E.; Ratnam, N. M.; Zhang, W.; Song, H.; Bailey, R.; Davis, D.; et al.J. Immunother. Cancer 2018, 6, 51.
38. [38]
  Horby, P.; Lim, W. S.; Emberson, J. R.; Mafham, M.; Bell, J. L.; Linsell, L.; Staplin, N.; Brightling, C.; Ustianowski, A.; Elmahi, E.; et al.N. Engl. J. Med. 2021, 384, 693.
39. [39]
  Malkawi, A. K.; Alzoubi, K. H.; Jacob, M.; Matic, G.; Ali, A.; Al Faraj, A.; Almuhanna, F.; Dasouki, M.; Rahman, A. M. A. Front. Pharmacol. 2018, 9, 46.
40. [40]
  Mogul, A.; Corsi, K.; McAuliffe, L. Ann. Pharmacother. 2019,53, 947.
41. [41]
  Jorgensen, S. C. J.; Tse, C. L. Y.; Burry, L. Pharmacotherapy 2020, 40, 843.
42. [42]
  Kulkarni, S.; Fisk, M.; Kostapanos, M.; Banham-Hall, E.; Bond, S.; Hernan-Sancho, E.; Norton, S.; Cheriyan, J.; Cope, A.; Galloway, J.; et al. Trials 2020, 21, 46.
43. [43]
  Kalil, A. C.; Patterson, T. F.; Mehta, A. K.; Tomashek, K. M.; Wolfe, C. R.; Ghazaryan, V.; Marconi, V. C.; Ruiz-Palacios, G. M.; Hsieh, L.;Kline, S.; et al. N. Engl. J. Med. 2021, 384, 795.
44. [44]
  Rodriguez-Garcia, J. L.; Sanchez-Nievas, G.; Arevalo-Serrano, J.; Garcia-Gomez, C.; Jimenez-Vizuete, J. M.; Martinez-Alfaro, E. Rheumatology 2021, 60, 399.
45. [45]
  Kramer, A.; Prinz, C.; Fichtner, F.; Fischer, A. L.; Thieme, V.; Grundeis, F.; Spagl, M.; Seeber, C.; Piechotta, V.; Metzendorf, M. I.; et al.Cochrane Db. Syst. Rev. 2022, 6, CD015209.
46. [46]
  Fu, Z.; Huang, B.; Tang, J.; Liu, S.; Liu, M.; Ye, Y.; Liu, Z.; Xiong, Y.; Zhu, W.; Cao, D.; et al. Nat. Commun. 2021, 12, 488.
47. [47]
  Osipiuk, J.; Azizi, S. A.; Dvorkin, S.; Endres, M.; Jedrzejczak, R.; Jones, K. A.; Kang, S.; Kathayat, R. S.; Kim, Y.; Lisnyak, V. G.; et al.Nat. Commun. 2021, 12, 743.
48. [48]
  Richardson, P.; Griffin, I.; Tucker, C.; Smith, D.; Oechsle, O.; Phelan, A.; Rawling, M.; Savory, E.; Stebbing, J. Lancet 2020, 395 (10223), e30.
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