Citation: Zhe Guan, Hongjie Song, Rui Liu. DNA历险记——氧化损伤篇[J]. University Chemistry, ;2022, 37(9): 220408. doi: 10.3866/PKU.DXHX202204087 shu

DNA历险记——氧化损伤篇

College of Chemistry, Sichuan University, Chengdu 610064, China

Corresponding author: Rui Liu, liur@scu.edu.cn
Received Date: 24 April 2022

DNA损伤指生物体生命过程中由外源因素或内源因素导致的DNA结构改变，包括DNA烷基化、氧化、错配、断裂等。虽然生物体内存在着DNA损伤修复机制，能在一定程度上修复损伤的DNA，但假如未被修复，积累起来的损伤将严重威胁生物体基因组的稳定性和生命安全。DNA氧化性损伤是最常见的损伤之一，而8-羟基脱氧鸟苷可以看作DNA氧化损伤的生物标志物，对8-羟基脱氧鸟苷的定量检测能够反映DNA氧化损伤的程度，对疾病的早期诊断和治疗至关重要。本文结合情景故事介绍了8-羟基脱氧鸟苷的产生过程、修复机制和检测手段。
- DNA damage and repair,
- Oxidative DNA damage,
- 8-hydroxydeoxyguanosine,
- Production process,
- Repair mechanism,
- Detection methods
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