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Citation: Yuling Zhang, Lichun Zhang. 舌尖上的毒素——河豚毒素[J]. University Chemistry, ;2022, 37(9): 220309. doi: 10.3866/PKU.DXHX202203097 shu

舌尖上的毒素——河豚毒素

Yuling Zhang ¹ ,
Lichun Zhang ^2,,

1.
Analytical and Testing Center, Sichuan University, Chengdu 610064, China;
2.
College of Chemistry, Sichuan University, Chengdu 610064, China

Corresponding author: Lichun Zhang, zhanglichun@scu.edu.cn
Received Date: 31 March 2022

河豚文化是我国饮食文化史上不可忽视的精彩篇章，河豚体内含有的河豚毒素作为一种强效的非蛋白质神经毒素，主要是通过对电压门控钠通道的高度选择性阻断起作用。河豚毒素是最为致命的毒素之一，人体摄入极低剂量（1.5–2.0 mg）便会致死，但目前发现在远低于LD₅₀水平给药时，河豚毒素展现出对神经性疼痛、癌症相关疼痛和毒品戒断等独特的治疗特性。本文简述河豚毒素结构的解析过程，并简要介绍了作用机制和未来在医疗上的应用前景。
- Tetrodotoxin,
- Neurotoxin,
- Sodium channel
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