Citation: Xinxin Peng, Lizhi Xu, Jiayi Zhang, Yanbo Jing, Songlin Tian, Yinghan Wu, Runyu Cao, JunLong Zhang. 镓元素在医疗卫生领域的应用：以抗癌与抗菌为例[J]. University Chemistry, ;2022, 37(3): 220305. doi: 10.3866/PKU.DXHX202203050 shu

镓元素在医疗卫生领域的应用：以抗癌与抗菌为例

1.
College of Chemistry and Molecular Engineering, Beijing National Laboratory for Molecular Sciences, Peking University, Beijing 100871, China;
2.
School of Pharmaceutical Sciences, Peking University, Beijing 100191, China

Received Date: 19 March 2022

镓（Ga）位于元素周期表第四周期第IIIA族，在临床疾病诊断和治疗中有重要应用。在体内，氧化还原惰性的三价镓（Ga（III））通常作为Fe（III）的竞争性抑制剂，破坏病变（肿瘤或感染）部位的铁稳态，从而实现抗肿瘤或抗菌的作用。在癌症诊疗方面，Ga（III）可以通过与转铁蛋白结合或独立运输的方式进入细胞：其放射性同位素（⁶⁷Ga或⁶⁸Ga）在癌组织中富集，实现肿瘤的放射影像学诊断；而非放射性Ga则通过抑制核糖核苷酸还原酶（RR）的正常功能、引起线粒体氧化应激等途径杀灭癌细胞。在抗菌方面，Ga与Fe在生化反应中形成竞争关系，从而破坏细菌生物被膜的结构和功能，实现抗菌作用。本文从化学原理出发，介绍了Ga在癌症的诊疗和抗菌领域的应用，并对Ga基药物的发展进行了展望。
- Gallium,
- Metallodrugs,
- Antineoplastic,
- Anti-microbial
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