Citation: Susu Gao, Xin Wang, Yaling Wang, Chunying Chen. 无机纳米佐剂的设计及其在人类冠状病毒疫苗免疫增效中的应用[J]. University Chemistry, ;2022, 37(3): 220104. doi: 10.3866/PKU.DXHX202201049 shu

无机纳米佐剂的设计及其在人类冠状病毒疫苗免疫增效中的应用

Susu Gao ^1,3 ,
Xin Wang ^1,3 ,
Yaling Wang ^1,2,3 ,
Chunying Chen ^1,2,3,,

1.
National Center for Nanoscience and Technology, Beijing 100190, China;
2.
The GBA National Institute for Nanotechnology Innovation, Guangzhou 510700, China;
3.
University of Chinese Academy of Sciences, Beijing 100049, China

Corresponding author: Chunying Chen, chenchy@nanoctr.cn
Received Date: 23 January 2022

近年来，人类冠状病毒的出现与传播对全球公共卫生防控带来了严重危机和巨大挑战。因此，迫切需要开发广谱的抗冠状病毒疫苗。疫苗一般具有抗原递送与免疫调节两个特点，而佐剂在疫苗免疫增效中发挥着关键作用。随着人们对金属免疫的认识增加，目前除了长期应用的铝佐剂外，其他无机金属元素及其纳米颗粒因其独特的性质发展成为具有潜力的候选佐剂。本文介绍了几种典型的无机纳米颗粒及其在抗人类冠状病毒疫苗佐剂中的应用并提出其设计要点，为后续个性化疫苗与新型无机纳米佐剂的开发提供思路。
- Inorganic nanoadjuvant,
- Coronavirus,
- Vaccine
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