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Citation: Xiangqing Feng, Haifeng Du. 2021年度诺贝尔化学奖：大道至简[J]. University Chemistry, ;2022, 37(1): 211201. doi: 10.3866/PKU.DXHX202112014 shu

2021年度诺贝尔化学奖：大道至简

Xiangqing Feng ^1,2 ,
Haifeng Du ^1,2,,

1.
CAS Key Laboratory of Molecular Recognition and Function, Institute for Chemistry, Chinese Academy of Sciences, Beijing 100190, China;
2.
University of Chinese Academy of Sciences, Beijing 100049, China

Corresponding author: Haifeng Du, haifengdu@iccas.ac.cn
Received Date: 7 December 2021

有机小分子成为继酶和金属催化剂之后发展的一类新型催化剂，被称为第三类催化。有机小分子催化作为一种精确的分子构建新工具，对手性新药研发产生了巨大影响，在药物、农药、化工、材料等领域都得到了广泛的应用。2021年的诺贝尔化学奖授予了德国化学家本杰明·利斯特和美国化学家大卫·迈克米伦，以表彰他们在这一领域做出的开创性重要贡献。本文简述了手性现象和不对称催化，有机小分子催化的发展历程及其催化优势和未来前景。
- Chirality,
- Asymmetric catalysis,
- Organic small molecule catalysis,
- Nobel prize in chemistry
1. [1]
  Kagan, H. B. In Comprehensive Asymmetric Catalysis; Jacobsen, E. N.; Pfaltz, A.; Yamamoto, H. Eds.; Springer-Verlag:Berlin, Heidelberg, Germany, 1999.
2. [2]
  Yang, X.-H.; Xie, J.-H.; Zhou, Q.-L. Org. Chem. Front. 2014, 1, 190.
3. [3]
  Bredig, G.; Fiske, P. S. Biochemische Zeitschrift 1913, 46, 7.
4. [4]
  Eder, U.; Sauer, G.; Weichert, R. Angew. Chem. Int. Ed. 1971, 10, 496.
5. [5]
  Hajos, Z. G.; Parrish, D. R. J. Org. Chem. 1974, 39, 1615.
6. [6]
  Yang, D.; Yip, Y.-C.; Tang, M.-W.; Wong, M.-K.; Zheng, J.-H.; Cheung, K.-K. J. Am. Chem. Soc. 1996, 118, 491.
7. [7]
  Yang, D. Acc. Chem. Res. 2004, 37, 497.
8. [8]
  Tu, Y.; Wang, Z.-X.; Shi, Y. J. Am. Chem. Soc. 1996, 118, 9806.
9. [9]
  Shi, Y. Acc. Chem. Res. 2004, 37, 488.
10. [10]
  Zhu, Y.; Wang, Q.; Cornwall, R. G.; Shi, Y. Chem. Rev. 2014, 114, 8199.
11. [11]
  Feng, X.; Du, H. Chin. J. Chem. 2021, 39, 2016.
12. [12]
  List, B.; Lerner, R. A.; Barbas, C. F. J. Am. Chem. Soc. 2000, 122, 2395.
13. [13]
  List, B. Acc. Chem. Res. 2004, 37, 548.
14. [14]
  Ahrendt, K. A.; Borths, C. J.; MacMillan, D. W. C. J. Am. Chem. Soc. 2000, 122, 4243.
15. [15]
  Ouellet, S. G.; Walji, A. M.; MacMillan, D. W. C. Acc. Chem. Res. 2007, 40, 1327.
16. [16]
  James, T.; van Gemmeren, M.; List, B. Chem. Rev. 2015, 115, 9388.
17. [17]
  Beeson, T. D.; Mastracchio, A.; Hong, J.-B.; Ashton, K.; MacMillan, D. W. C. Science 2007, 316, 582.
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