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Citation: Zheng Cao, Ling Lin, Yan Wu, Shiyu Hu, Xiaojian Liao, Pengju Feng. 苯酚衍生物的电化学选择性C-H唑胺化反应研究[J]. University Chemistry, ;2022, 37(7): 211104. doi: 10.3866/PKU.DXHX202111049 shu

苯酚衍生物的电化学选择性C-H唑胺化反应研究

College of Chemistry and Materials Science, Jinan University, Guangzhou 510632, China

Received Date: 15 November 2021

电化学有机合成以电子为清洁的反应试剂，近年来得到快速发展。本实验以苯酚衍生物和唑类为原料通过电化学氧化实现脱氢偶联，构筑C―N键，合成唑胺化芳烃产物，继而探索反应的可重复性以及底物的兼容性，尝试建立适合本科创新实验研究的操作流程。实验涉及C―H官能团化反应，为当下有机合成科研前沿，反应操作简单，安全高效，反应时长可控，利用薄层色谱能方便监测反应的进程。产物可由硅胶柱层析法分离纯化，化合物结构可通过质谱、核磁共振波谱鉴定。该反应立足于绿色有机合成，综合应用有机化学与物理化学交叉学科知识，开发含氮化合物实用合成方法。
- Electrosynthesis,
- C-N coupling,
- C-H functionalization,
- Green chemistry,
- N-Azolation
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