Citation: Xiaoyun Hu, Ling Ma, Xinran Yin, Dan Chen, Zhongqiang Zhou, Daohong Zhang. Synthesis and Characterization of (2R,3R)-1,4-Dimethoxyl-1,1,4,4-tetraphenyl-2,3-butanediol : A Recommended Comprehensive Chemistry Experiment[J]. University Chemistry, ;2022, 37(12): 211103. doi: 10.3866/PKU.DXHX202111036 shu

Synthesis and Characterization of (2R,3R)-1,4-Dimethoxyl-1,1,4,4-tetraphenyl-2,3-butanediol : A Recommended Comprehensive Chemistry Experiment

School of Chemistry and Materials Science, South-Central Minzu University, Wuhan 430074, China

Corresponding author: Xiaoyun Hu, xyhu@mail.scuec.edu.cn
Received Date: 10 November 2021

Synthesis and characterization of (2R,3R)-1,4-dimethoxyl-1,1,4,4-tetraphenyl-2,3-butanediol is an innovative experiment from the “comprehensive chemistry experiment” course. While (2R,3R)-1,1,4,4-tetraphenylbutanetetraol has found diverse applications in asymmetric organic synthesis, its preparation cost is high, and the synthesis operation is cumbersome and dangerous. (2R,3R)-1,4-dimethoxyl-1,1,4,4-tetraphenyl-2,3-butanediol was synthesized via a highly regioselective reaction of (2R,3R)-1,1,4,4-tetraphenyl-butanetetraol. We propose a comprehensive chemistry experiment that includes classical reaction types, synthetic operations, and characterization analysis. This experiment will strengthen students’ understanding of the theoretical knowledge of organic chemistry and cultivate and improve students’ comprehensive experimental ability. In addition, this experiment also can establish the green chemistry concept among students and stimulate students’ scientific research interest and their awareness of scientific research innovations. Therefore, this experiment is suitable for use as a college chemistry experiment.
- Comprehensive experiment,
- Region-selective reaction,
- (2R,3R)-1,4-Dimethoxyl-1,1,4,4-tetraphenyl-2,3-butanediol,
- Green chemistry
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