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Citation: Chengbo Sun, Zhubao Zhang, Yizhong Chen, Yuhao Kuang, Xiaojian Liao, Pengju Feng. 一锅三步由硝基芳烃合成邻氨基酚衍生物[J]. University Chemistry, ;2022, 37(5): 211101. doi: 10.3866/PKU.DXHX202111018 shu

一锅三步由硝基芳烃合成邻氨基酚衍生物

College of Chemistry and Materials Science, Jinan University, Guangzhou 510632, China

Received Date: 8 November 2021

硝基的选择性还原，羟胺的选择性保护，以及[3，3]-σ重排都是有机化学的基础内容。本实验将此三个基本反应融入于3.5 h的紧凑一锅法化学反应中，反应现象丰富且便于观察，利用薄层色谱能方便监测反应的进程。反应可以从简单的硝基芳烃一锅获取高官能化邻氨基酚衍生物，同时三步反应可以分解为三个单独的反应，且均能高收率得到相应化合物。产物可由硅胶柱层析纯化，化合物结构通过质谱、核磁共振波谱的解析进一步确定。该反应立足有机化学硝基官能团基础知识，适用于本科生学习官能团转化知识，观测多种实验现象，同时反应操作多样，用时紧凑，产率高，在邻氨基酚类衍生物制备中具有广泛的应用潜力。
- One-pot procedure,
- Selective reduction,
- Protection of hydroxylamine,
- [3,3]-σ Rearrangement,
- o-Aminophenol
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