Citation: Kai Xiong, Yu Chen, Liangnian Ji, Hui Chao. 线粒体靶向铱(III)配合物克服肿瘤耐药[J]. University Chemistry, ;2022, 37(3): 211009. doi: 10.3866/PKU.DXHX202110094 shu

线粒体靶向铱(III)配合物克服肿瘤耐药

MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou 510006, China

Received Date: 29 October 2021

以顺铂代表的金属铂类药物在临床抗肿瘤治疗取得了巨大的成功，但铂类药物的毒副作用和耐药性很大程度上限制了其临床使用范围及疗效。以结构稳定、具有独特三维立体构型的铱（III）配合物为构筑单元，可以有效跳出传统铂类药物的局限。线粒体科学是当今化学、生命科学及分子医学最为活跃的交叉前沿研究领域之一。作为可预见的治疗靶点，线粒体靶向抗肿瘤试剂在克服肿瘤耐药、治疗肿瘤中具有十分突出的优势。本文中，结合铂类化疗药物耐药机制，同时以本课题组近年工作为基础，简要介绍具有线粒体靶向的环金属铱（III）配合物克服肿瘤耐药研究进展。
- Cyclometalated iridium(III) complexes,
- Mitochondrial targeting,
- Cisplatin,
- Tumour drug-resistant
1. [1]
  Bray, F.; Ferlay, J.; Soerjomataram, I.; Siegel, R. L.; Torre, L. A.; Jemal, A. CA Cancer J. Clin. 2018, 68 (6), 394.
2. [2]
  Sung, H.; Ferlay, J.; Siegel, R. L.; Laversanne, M.; Soerjomataram, I.; Jemal, A.; Bray, F. CA Cancer J. Clin. 2021, 71 (3), 209.
3. [3]
4. [4]
  Rosenberg, B.; Vancamp, L.; Trosko, J. E.; Mansour, V. H. Nature 1969, 222 (5191), 385.
5. [5]
  Jung, Y.; Lippard, S. J. Chem. Rev. 2007, 107 (5), 1387.
6. [6]
  Vasan, N.; Baselga, J.; Hyman, D. M. Nature 2019, 575 (7782), 299.
7. [7]
  Hanahan, D.; Weinberg, R. A. Cell 2011, 144 (5), 646.
8. [8]
  Koppenol, W. H.; Bounds, P. L.; Dang, C. V. Nat. Rev. Cancer 2011, 11 (5), 325.
9. [9]
  Yang, Y.; Karakhanova, S.; Hartwig, W.; D'Haese, J. G.; Philippov, P. P.; Werner, J.; Bazhin, A. V. J. Cell. Physiol. 2016, 231 (12), 2570.
10. [10]
  Wu, W.-S. Cancer Metastasis Rev. 2006, 25 (4), 695.
11. [11]
  White, J. D.; Haley, M. M.; DeRose, V. J. Acc. Chem. Res. 2015, 49 (1), 56.
12. [12]
  Borst, P.; Evers, R.; Kool, M.; Wijnholds, J. J. Natl. Cancer Inst. 2000, 92 (16), 1295.
13. [13]
  Galluzzi, L.; Senovilla, L.; Vitale, I.; Michels, J.; Martins, I.; Kepp, O.; Castedo, M.; Kroemer, G. Oncogene 2012, 31 (15), 1869.
14. [14]
  Ferry, K. V.; Hamilton, T. C.; Johnson, S. W. Biochem. Pharmacol. 2000, 60 (9), 1305.
15. [15]
  Assaraf, Y. G.; Brozovic, A.; Goncalves, A. C.; Jurkovicova, D.; Line, A.; Machuqueiro, M.; Saponara, S.; Sarmento-Ribeiro, A. B.; Xavier, C. P. R.; Vasconcelos, M. H. Drug Resist. Updat. 2019, 46, 100645.
16. [16]
  Chen, Y.; Guan, R.; Zhang, C.; Huang, J.; Ji, L.; Chao, H. Coord. Chem. Rev. 2016, 310, 16.
17. [17]
  Chen, Y.; Rees, T. W.; Ji, L.; Chao, H. Curr. Opin. Chem. Biol. 2018, 43, 51.
18. [18]
  Ouyang, C.; Chen, L.; Rees, T. W.; Chen, Y.; Liu, J.; Ji, L.; Long, J.; Chao, H. Chem. Commun. 2018, 54 (49), 6268.
19. [19]
  Zhang, C.; Guan, R.; Liao, X.; Ouyang, C.; Rees, T. W.; Liu, J.; Chen, Y.; Ji, L.; Chao, H. Chem. Commun. 2019, 55 (83), 12547.
20. [20]
  Xiong, K.; Qian, C.; Yuan, Y.; Wei, L.; Liao, X.; He, L.; Rees, T. W.; Chen, Y.; Wan, J.; Ji, L.; Chao, H. Angew. Chem. Int. Ed. 2020, 59 (38), 16631.
21. [21]
  He, L.; Xiong, K.; Wang, L.; Guan, R.; Chen, Y.; Ji, L.; Chao, H. Chem. Commun. 2021, 57 (67), 8308.
22. [22]
  Guan, R.; Chen, Y.; Zeng, L.; Rees, T. W.; Jin, C.; Huang, J.; Chen, Z. S.; Ji, L.; Chao, H. Chem. Sci. 2018, 9 (23), 5183.
23. [23]
  Guan, R. L.; Xie, L. N.; Wang, L. L.; Zhou, Y.; Chen, Y.; Ji, L. N.; Chao, H. Inorg. Chem. Front. 2021, 8 (7), 1788.
24. [24]
  Xiong, K.; Zhou, Y.; Lin, X.; Kou, J.; Lin, M.; Guan, R.; Chen, Y.; Ji, L.; Chao, H. Photochem. Photobiol. 2021, in press. doi:10.1111/php.13404
25. [25]
  Li, J.; Chen, H.; Zeng, L.; Rees, T. W.; Xiong, K.; Chen, Y.; Ji, L.; Chao, H. Inorg. Chem. Front. 2019, 6 (4), 1003.
26. [26]
  Ke, L.; Zhang, C.; Liao, X.; Qiu, K.; Rees, T. W.; Chen, Y.; Zhao, Z.; Ji, L.; Chao, H. Chem. Commun. 2019, 55 (69), 10273.
1. [1]
  Jing WU , Puzhen HUI , Huilin ZHENG , Pingchuan YUAN , Chunfei WANG , Hui WANG , Xiaoxia GU . Synthesis, crystal structures, and antitumor activities of transition metal complexes incorporating a naphthol-aldehyde Schiff base ligand. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2422-2428. doi: 10.11862/CJIC.20240278
2. [2]
  Aiai WANG , Lu ZHAO , Yunfeng BAI , Feng FENG . Research progress of bimetallic organic framework in tumor diagnosis and treatment. Chinese Journal of Inorganic Chemistry, 2024, 40(10): 1825-1839. doi: 10.11862/CJIC.20240225
3. [3]
  Tingting XU , Wenjing ZHANG , Yongbo SONG . Research advances of atomic precision coinage metal nanoclusters in tumor therapy. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2275-2285. doi: 10.11862/CJIC.20240229
4. [4]
  Lu XU , Chengyu ZHANG , Wenjuan JI , Haiying YANG , Yunlong FU . Zinc metal-organic framework with high-density free carboxyl oxygen functionalized pore walls for targeted electrochemical sensing of paracetamol. Chinese Journal of Inorganic Chemistry, 2024, 40(5): 907-918. doi: 10.11862/CJIC.20230431
5. [5]
  Ke QIAO , Yanlin LI , Shengli HUANG , Guoyu YANG . Advancements in asymmetric catalysis employing chiral iridium (ruthenium) complexes. Chinese Journal of Inorganic Chemistry, 2024, 40(11): 2091-2104. doi: 10.11862/CJIC.20240265
6. [6]
  Qiaowen CHANG , Ke ZHANG , Guangying HUANG , Nuonan LI , Weiping LIU , Fuquan BAI , Caixian YAN , Yangyang FENG , Chuan ZUO . Syntheses, structures, and photo-physical properties of iridium phosphorescent complexes with phenylpyridine derivatives bearing different substituting groups. Chinese Journal of Inorganic Chemistry, 2025, 41(2): 235-244. doi: 10.11862/CJIC.20240311
7. [7]
  Jinfeng Chu , Yicheng Wang , Ji Qi , Yulin Liu , Yan Li , Lan Jin , Lei He , Yufei Song . Comprehensive Chemical Experiment Design: Convenient Preparation and Characterization of an Oxygen-Bridged Trinuclear Iron(III) Complex. University Chemistry, 2024, 39(7): 299-306. doi: 10.3866/PKU.DXHX202310105
8. [8]
  Keweiyang Zhang , Zihan Fan , Liyuan Xiao , Haitao Long , Jing Jing . Unveiling Crystal Field Theory: Preparation, Characterization, and Performance Assessment of Nickel Macrocyclic Complexes. University Chemistry, 2024, 39(5): 163-171. doi: 10.3866/PKU.DXHX202310084
9. [9]
  Tianyun Chen , Ruilin Xiao , Xinsheng Gu , Yunyi Shao , Qiujun Lu . Synthesis, Crystal Structure, and Mechanoluminescence Properties of Lanthanide-Based Organometallic Complexes. University Chemistry, 2024, 39(5): 363-370. doi: 10.3866/PKU.DXHX202312017
10. [10]
  Wenjing ZHANG , Xiaoqing WANG , Zhipeng LIU . Recent developments of inorganic metal complex-based photothermal materials and their applications in photothermal therapy. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2356-2372. doi: 10.11862/CJIC.20240254
11. [11]
  Hong Wu , Yuxi Wang , Hongyan Feng , Xiaokui Wang , Bangkun Jin , Xuan Lei , Qianghua Wu , Hongchun Li . Application of Computational Chemistry in the Determination of Magnetic Susceptibility of Metal Complexes. University Chemistry, 2025, 40(3): 116-123. doi: 10.12461/PKU.DXHX202405141
12. [12]
  Hong RAO , Yang HU , Yicong MA , Chunxin LÜ , Wei ZHONG , Lihua DU . Synthesis and in vitro anticancer activity of phenanthroline-functionalized nitrogen heterocyclic carbene homo- and heterobimetallic silver/gold complexes. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2429-2437. doi: 10.11862/CJIC.20240275
13. [13]
  Jiaxun Wu , Mingde Li , Li Dang . The R eaction of Metal Selenium Complexes with Olefins as a Tutorial Case Study for Analyzing Molecular Orbital Interaction Modes. University Chemistry, 2025, 40(3): 108-115. doi: 10.12461/PKU.DXHX202405098
14. [14]
  Siyi ZHONG , Xiaowen LIN , Jiaxin LIU , Ruyi WANG , Tao LIANG , Zhengfeng DENG , Ao ZHONG , Cuiping HAN . Targeting imaging and detection of ovarian cancer cells based on fluorescent magnetic carbon dots. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1483-1490. doi: 10.11862/CJIC.20240093
15. [15]
  Zuozhong Liang , Lingling Wei , Yiwen Cao , Yunhan Wei , Haimei Shi , Haoquan Zheng , Shengli Gao . Exploring the Development of Undergraduate Scientific Research Ability in Basic Course Instruction: A Case Study of Alkali and Alkaline Earth Metal Complexes in Inorganic Chemistry. University Chemistry, 2024, 39(7): 247-263. doi: 10.3866/PKU.DXHX202310103
16. [16]
  Tingyu Zhu , Hui Zhang , Wenwei Zhang . Exploration and Practice of Ideological and Political Education in the Course of Experiments on Chemical Functional Molecules: Synthesis and Catalytic Performance Study of Chiral Mn(III)Cl-Salen Complex. University Chemistry, 2024, 39(4): 75-80. doi: 10.3866/PKU.DXHX202311011
17. [17]
  Di WU , Ruimeng SHI , Zhaoyang WANG , Yuehua SHI , Fan YANG , Leyong ZENG . Construction of pH/photothermal dual-responsive delivery nanosystem for combination therapy of drug-resistant bladder cancer cell. Chinese Journal of Inorganic Chemistry, 2024, 40(9): 1679-1688. doi: 10.11862/CJIC.20240135
18. [18]
  Chunmei GUO , Weihan YIN , Jingyi SHI , Jianhang ZHAO , Ying CHEN , Quli FAN . Facile construction and peroxidase-like activity of single-atom platinum nanozyme. Chinese Journal of Inorganic Chemistry, 2024, 40(9): 1633-1639. doi: 10.11862/CJIC.20240162
19. [19]
  Ping Song , Nan Zhang , Jie Wang , Rui Yan , Zhiqiang Wang , Yingxue Jin . Experimental Teaching Design on Synthesis and Antitumor Activity Study of Cu-Pyropheophorbide-a Methyl Ester. University Chemistry, 2024, 39(6): 278-286. doi: 10.3866/PKU.DXHX202310087
20. [20]
  Jiahui CHEN , Tingting ZHENG , Xiuyun ZHANG , Wei LÜ . Research progress of near-infrared absorption inorganic nanomaterials in photothermal and photodynamic therapy of tumors. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2396-2414. doi: 10.11862/CJIC.20240106

Get Citation

PDF

XML

Metrics

PDF Downloads(10)
Abstract views(1183)
HTML views(257)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142