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Citation: Zonghao Yu, Yuxuan Hong, Xinyin Cao, Hongmei Sun, Bei Zhao, Yingming Yao. 苯甲醇的绿色选择性氧化[J]. University Chemistry, ;2022, 37(5): 211005. doi: 10.3866/PKU.DXHX202110055 shu

苯甲醇的绿色选择性氧化

College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, Jiangsu Province, China

Received Date: 18 October 2021

醇的氧化是制备醛和酮的重要反应之一，也是有机化学理论教学和实验教学的一个重点内容。目前，大多数本科生实验教材安排了环己醇氧化合成环己酮的实验。虽然现有实验教材提供了一例将伯醇氧化为醛的方案，即采用Na₂WO₄×2H₂O/（C₄H₉）₄NHSO₄催化体系，在90℃用H₂O₂将苯甲醇选择性氧化为苯甲醛，但是存在着产率低、安全性不高和重金属污染等问题。本文采用Fe （NO₃）₃×9H₂O、4-羟基-2，2，6，6-四甲基哌啶氧化物（4-OH-TEMPO）和乙酸（HOAc）为催化剂、O₂为氧化剂，以H₂O为溶剂，在温和的反应条件下高选择性地将苯甲醇氧化为苯甲醛，分离产率可达91%，这为伯醇的选择性氧化提供了一个低成本且高效绿色的实验教学新方案。同时，在实验过程中引入薄层色谱、气相色谱、快速制备液相色谱和核磁共振氢谱等手段对产物进行分离、提纯和表征，有效提升了本科生的综合实验技能和科研素养。
- Primary alcohol,
- Fe(III) salt,
- Selective oxidation,
- Benzaldehyde,
- Green chemistry
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