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Citation: Jiazhu Li, Yingying Hong, Yingxiu Man, Yinghao Li, Qingzhong Li, Tao He. 7-硝基苯并噻吩-2-甲酸乙酯合成实验的优化与改进[J]. University Chemistry, ;2022, 37(5): 211003. doi: 10.3866/PKU.DXHX202110030 shu

7-硝基苯并噻吩-2-甲酸乙酯合成实验的优化与改进

College of Chemistry and Chemical Engineering, Yantai University, Yantai 264005, Shangdong Province, China

Corresponding author: Jiazhu Li, jiazhu82@ytu.edu.cn
Received Date: 12 October 2021

有机合成实验是化学专业学生重要单列实验课程，目前选用的有机合成实验项目多为单步骤合成操作，对学生多步合成的衔接、化合物的检测和鉴定等方面的训练存在不足。7-硝基苯并噻吩-2-甲酸乙酯的合成是本校应用化学专业学生有机合成实验课程中的一个综合训练项目，但存在耗时较长、产率不稳定，后处理难度较大及使用有毒试剂等问题。本项目旨在改进苯并噻吩环系的合成方法和步骤，降低试剂用量，提高产率，优化后处理过程，减少有毒物使用和三废排放，使之更符合教学实验和绿色化学要求；同时，改进后的实验增加了有机波谱分析内容，训练学生通过红外光谱、核磁共振氢谱及质谱等方式对目标化合物进行表征，更有利于学生综合素质的培养。
- Organic synthesis,
- Multi-step synthesis,
- Green chemistry,
- Benzothiophene
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