Citation: Menglong Zhao, Dailei Yuan, Zi Ye, Fang Fang, Yuena Yu. 电化学氧化脱氢交叉偶联构建C―N键——电化学技术在有机化学实验教学中的设计与探索[J]. University Chemistry, ;2022, 37(5): 210910. doi: 10.3866/PKU.DXHX202109108 shu

电化学氧化脱氢交叉偶联构建C―N键——电化学技术在有机化学实验教学中的设计与探索

Department of Chemistry, Southern University of Science and Technology, Shenzhen 518055, Guangdong Province, China

Corresponding author: Yuena Yu, yuyn@sustech.edu.cn
Received Date: 29 September 2021

将绿色电化学合成策略引入教学，通过电化学氧化偶联构建C―N键，实现了芳胺对位高选择性胺化，并通过循环伏安法对反应机理进行探索。此方案为科研转化的、开放性综合有机化学实验。反应以直流恒流电为电源，在室温空气条件下进行，首先以吩噻嗪和N，N-二甲基苯胺为模板底物，对电流、电量和电解质三个影响因素进行考察；确定最优条件后接着考察芳胺的适用性；最后通过循环伏安法对反应规律进行探索。实验深入融合贯穿了前沿科研成果的科学思路与创新理念，通过实验的开展，可以提升学生专业综合素质、激发学生创新意识。
- Organic electrochemical synthesis,
- Oxidative cross-coupling,
- C-N bond,
- Quantitative NMR,
- Cyclic voltammetry
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