Home

Citation: Jun Xuan, Weiwei Jin, Lei Li, Xiao Lian, Qiong Zhang, Chenjiang Liu. 连续流动条件下硝酮的光化学合成在本科实验教学中的应用探索[J]. University Chemistry, ;2022, 37(7): 210904. doi: 10.3866/PKU.DXHX202109049 shu

连续流动条件下硝酮的光化学合成在本科实验教学中的应用探索

Jun Xuan ¹ ,
Weiwei Jin ² ,
Lei Li ¹ ,
Xiao Lian ¹ ,
Qiong Zhang ¹ ,
Chenjiang Liu ²

1.
College of Chemistry & Chemical Engineering, Anhui University, Hefei 230601, China;
2.
College of Chemistry, Xinjiang University, Urumqi 830046, China

Received Date: 16 September 2021

为有效拓展现阶段本科有机化学教学实验开设的范围，让学生了解学科前沿研究热点与新合成技术，本实验以硝酮的光化学合成为导向，将连续流动化学和有机光化学融合运用于本科实验教学。反应以苯基重氮酸酯和亚硝基苯为起始原料，蓝色LED为光源，通过亚硝基苯对光照产生的卡宾中间体的捕捉实现硝酮的光化学合成。反应过程中无需使用无水无氧等复杂操作，且简易流动光化学反应器易于搭建、价格低廉，适合本科生在基础实验室中操作完成。通过本实验，还可以让学生熟悉微量有机反应中薄层分析法、柱层析及相关仪器的操作，并将所学的核磁共振氢谱/碳谱等理论知识运用到产物的结构分析中，提升学生的主观能动性、综合实践能力和环保意识。
- Flow chemistry,
- Photo-chemistry,
- Nitrone,
- Undergraduate laboratory teaching
1. [1]
2. [2]
3. [3]
4. [4]
  Pfeiffer, J. Y.; Beauchemin, A. M. J. Org. Chem. 2009, 74(21), 8381.
5. [5]
  Soldaini, G.; Cardona, F.; Goti, A. Org. Lett. 2007, 9(3), 473.
6. [6]
7. [7]
8. [8]
1. [1]
  Fei Liu , Dong-Yang Zhao , Kai Sun , Ting-Ting Yu , Xin Wang . Comprehensive Experimental Design for Photochemical Synthesis, Analysis, and Characterization of Seleno-Containing Medium-Sized N-Heterocycles. University Chemistry, 2024, 39(3): 369-375. doi: 10.3866/PKU.DXHX202309047
2. [2]
  Lina Liu , Xiaolan Wei , Jianqiang Hu . Exploration of Subject-Oriented Undergraduate Comprehensive Chemistry Experimental Teaching Based on the “STS Concept”: Taking the Experiment of Gold Nanoparticles as an Example. University Chemistry, 2024, 39(10): 337-343. doi: 10.12461/PKU.DXHX202405112
3. [3]
  Wanmin Cheng , Juan Du , Peiwen Liu , Yiyun Jiang , Hong Jiang . Photoinitiated Grignard Reagent Synthesis and Experimental Improvement in Triphenylmethanol Preparation. University Chemistry, 2024, 39(5): 238-242. doi: 10.3866/PKU.DXHX202311066
4. [4]
  Rui Gao , Ying Zhou , Yifan Hu , Siyuan Chen , Shouhong Xu , Qianfu Luo , Wenqing Zhang . Design, Synthesis and Performance Experiment of Novel Photoswitchable Hybrid Tetraarylethenes. University Chemistry, 2024, 39(5): 125-133. doi: 10.3866/PKU.DXHX202310050
5. [5]
  Zhen Yao , Bing Lin , Youping Tian , Tao Li , Wenhui Zhang , Xiongwei Liu , Wude Yang . Visible-Light-Mediated One-Pot Synthesis of Secondary Amines and Mechanistic Exploration. University Chemistry, 2024, 39(5): 201-208. doi: 10.3866/PKU.DXHX202311033
6. [6]
  Chun-Lin Sun , Yaole Jiang , Yu Chen , Rongjing Guo , Yongwen Shen , Xinping Hui , Baoxin Zhang , Xiaobo Pan . Construction, Performance Testing, and Practical Applications of a Home-Made Open Fluorescence Spectrometer. University Chemistry, 2024, 39(5): 287-295. doi: 10.3866/PKU.DXHX202311096
7. [7]
  Tingting Yu , Si Chen , Lianglong Sun , Tongtong Shi , Kai Sun , Xin Wang . Comprehensive Experimental Design for the Photochemical Synthesis, Analysis, and Characterization of Difluoropyrroles. University Chemistry, 2024, 39(11): 196-203. doi: 10.3866/PKU.DXHX202401022
8. [8]
  Yang Liu , Ying Yu , Yilei Wang , Chao Chen . Building of a High-Quality, Multi-Level Teaching Team in Chemistry Experimental Teaching Center. University Chemistry, 2024, 39(7): 166-171. doi: 10.12461/PKU.DXHX202405069
9. [9]
  Dongcheng Liu , Xiaokun Li , Huancheng Hu , Cunji Gao , Qiong Hu , Shuting Li , Yuning Liang . Chemistry Experimental Teaching Reform for the Promotion of Training Exceptional Chemistry Teachers for Normal Schools. University Chemistry, 2024, 39(8): 1-6. doi: 10.3866/PKU.DXHX202311072
10. [10]
  Zongpei Zhang , Yanyang Li , Yanan Si , Kai Li , Shuangquan Zang . Developing a Chemistry Experiment Center Employing a Multifaceted Approach to Serve High-Quality Laboratory Education. University Chemistry, 2024, 39(7): 13-19. doi: 10.12461/PKU.DXHX202404041
11. [11]
  Qizhi Yao , Gu Jin , Pingping Zhu . Modular Analytical Chemistry Experimental Teaching Based on “Comprehensive + Exploratory” Experiments: “One Student, One Plan”, Individualized Experimental Teaching Method. University Chemistry, 2024, 39(3): 143-148. doi: 10.3866/PKU.DXHX202309071
12. [12]
  Fang Li , Yang Liu , Jie Han , Xiaohang Qiu . Exploration of Safety Management and Practice in University Chemistry Laboratory Teaching. University Chemistry, 2024, 39(4): 48-53. doi: 10.3866/PKU.DXHX202309009
13. [13]
  Xiaohang Qiu , Yang Liu , Fei Ding , Jie Han , Yijun Li . Construction of a Demonstration Center for Experimental Chemistry Education in the New Era. University Chemistry, 2024, 39(7): 26-31. doi: 10.12461/PKU.DXHX202404112
14. [14]
  Junlin Yan , Changhao Wang , Quanguo Zhai , Chenghui Liu , Dong Xue . A New Construction Model and Practice of Demonstration Center for Experimental Chemistry Education. University Chemistry, 2024, 39(7): 64-68. doi: 10.12461/PKU.DXHX202405005
15. [15]
  Haorui Gu , Ning Li , Zhanxiang Liu , Xufeng Lin . Construction and Development of Chemistry Experimental Teaching Center under the Background of the “101 Plan”. University Chemistry, 2024, 39(7): 110-115. doi: 10.12461/PKU.DXHX202405022
16. [16]
  Nuo Zhang , Xiaojun Sun , Hongmin Ma , Yan Li , Xiang Ren , Dan Wu , Chuannan Luo , Qin Wei . Construction and Practice of National Experimental Teaching Demonstration Center of Applied Chemistry. University Chemistry, 2024, 39(7): 116-120. doi: 10.12461/PKU.DXHX202405031
17. [17]
  Yan Zhao , Weiping Luo , Haoran Liu , Yongqing Kuang , Zhaoyang Wu , Weijun Yang , Yongjun Li , Dongcai Guo . Construction and Practice of the Chemistry and Chemical Engineering Experimental Teaching Center of Hunan University. University Chemistry, 2024, 39(7): 147-152. doi: 10.12461/PKU.DXHX202405059
18. [18]
  Yecang Tang , Shan Ling , Zhen Fang . Exploration of a Hierarchical and Integration-Oriented Talent Training Model in the Demonstration Center for Experimental Chemistry Education. University Chemistry, 2024, 39(7): 188-192. doi: 10.12461/PKU.DXHX202405107
19. [19]
  Hong Wu , Yuxi Wang , Hongyan Feng , Xiaokui Wang , Bangkun Jin , Xuan Lei , Qianghua Wu , Hongchun Li . Application of Computational Chemistry in the Determination of Magnetic Susceptibility of Metal Complexes. University Chemistry, 2025, 40(3): 116-123. doi: 10.12461/PKU.DXHX202405141
20. [20]
  Yonghong Ruan , Yuhua Weng , Pingping Wu , Yinyun Lü , Zhaobin Chen , Zhiqiang Dong , Yiru Wang , Huijun Zhang , Lina Wu , Ruming Yuan , Yanping Ren , Xiaoyu Cao , Shunliu Deng . Deepening the Reform of Experimental Teaching System and Promoting the High Quality Development of National Demonstration Center for Experimental Education: Construction and Achievements of National Demonstration Center for Experimental Chemistry Education (Xiamen University). University Chemistry, 2024, 39(7): 237-246. doi: 10.12461/PKU.DXHX202406096

Get Citation

PDF

XML

Metrics

PDF Downloads(6)
Abstract views(897)
HTML views(192)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Address：Zhongguancun North First Street 2,100190 Beijing, PR China Tel: +86-010-82449177-888

DownLoad: Full-Size Img PowerPoint

Return