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Citation: Nana Sun, Like Deng, Yue Sun, Weijin Gu, Bingxiang Wang, Langui Xie. Beckmann重排合成N-(2-萘基)乙酰胺的综合实验设计[J]. University Chemistry, ;2022, 37(6): 210807. doi: 10.3866/PKU.DXHX202108077 shu

Beckmann重排合成N-(2-萘基)乙酰胺的综合实验设计

Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China

Received Date: 24 August 2021

贝克曼重排反应实验是大学有机化学基础实验教学中的重要内容之一。目前实验教学中主要采用的方案是在浓硫酸或多聚磷酸的条件下回流反应。本实验通过三苯基膦和四氯化碳原位形成Appel盐引发反应，使贝克曼重排反应能够在中性、常温条件下进行。该实验方案避免了强腐蚀性酸和高温回流条件的使用，不仅具有操作简单、产物收率高、重复性好的特点，同时在实验安全方面表现出明显的优势。
- Beckmann rearrangement,
- Safety,
- Appel's salt
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